Propargyl-PEG3-Tos
- Product Name
- Propargyl-PEG3-Tos
- CAS No.
- 1119249-30-7
- Chemical Name
- Propargyl-PEG3-Tos
- Synonyms
- Propargyl-PEG3-Tos;2-(2-prop-2-ynoxyethoxy)ethyl 4-methylbenzenesulfonate;2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate;Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-(4-methylbenzenesulfonate)
- CBNumber
- CB13363992
- Molecular Formula
- C14H18O5S
- Formula Weight
- 298.35
- MOL File
- 1119249-30-7.mol
Propargyl-PEG3-Tos Property
- storage temp.
- Storage temp. 2-8°C
- form
- Oil
- color
- Light yellow to yellow
- InChI
- InChI=1S/C14H18O5S/c1-3-8-17-9-10-18-11-12-19-20(15,16)14-6-4-13(2)5-7-14/h1,4-7H,8-12H2,2H3
- InChIKey
- XOLBARIQCXNLPS-UHFFFAOYSA-N
- SMILES
- C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCOCC#C
N-Bromosuccinimide Price
- Product number
- BP-22712
- Product name
- Propargyl-PEG4-Tos
- Purity
- 98%
- Packaging
- 500mg
- Price
- $890
- Updated
- 2021/12/16
- Product number
- BP-23277
- Product name
- Propargyl-PEG3-Tos
- Purity
- 98%
- Packaging
- 1g
- Price
- $1500
- Updated
- 2021/12/16
Propargyl-PEG3-Tos Chemical Properties,Usage,Production
Description
Propargyl-PEG3-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Uses
Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1]. Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781
Propargyl-PEG3-Tos Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propargyl-PEG3-Tos manufacturers
- Product
- Propargyl-PEG3-Tos 1119249-30-7
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >99.00%
- Supply Ability
- 5g
- Release date
- 2024-03-26