Propargyl-PEG3-Tos

Product Name: Propargyl-PEG3-Tos
CAS No.: 1119249-30-7
Chemical Name: Propargyl-PEG3-Tos
Synonyms: Propargyl-PEG3-Tos;2-(2-prop-2-ynoxyethoxy)ethyl 4-methylbenzenesulfonate;2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate;Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-(4-methylbenzenesulfonate)
CBNumber: CB13363992
Molecular Formula: C14H18O5S
Formula Weight: 298.35
MOL File: 1119249-30-7.mol

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Propargyl-PEG3-Tos Property

storage temp.: Storage temp. 2-8°C
form: Oil
color: Light yellow to yellow
InChI: InChI=1S/C14H18O5S/c1-3-8-17-9-10-18-11-12-19-20(15,16)14-6-4-13(2)5-7-14/h1,4-7H,8-12H2,2H3
InChIKey: XOLBARIQCXNLPS-UHFFFAOYSA-N
SMILES: C(OS(C1=CC=C(C)C=C1)(=O)=O)COCCOCC#C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-22712
Product name: Propargyl-PEG4-Tos
Purity: 98%
Packaging: 500mg
Price: $890
Updated: 2021/12/16

BroadPharm

Product number: BP-23277
Product name: Propargyl-PEG3-Tos
Purity: 98%
Packaging: 1g
Price: $1500
Updated: 2021/12/16

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Propargyl-PEG3-Tos Chemical Properties,Usage,Production

Description

Propargyl-PEG3-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Uses

Tos-PEG2-O-Propargyl is a PEG-based PROTAC linker can be used in the synthesis of Thalidomide-O-PEG2-propargyl (HY-126458)[1]. Tos-PEG2-O-Propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.

IC 50

PEGs

References

[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781

Propargyl-PEG3-Tos Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from Propargyl-PEG3-Tos manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG3-Tos 1119249-30-7
Price: US $0.00/g
Min. Order: 5g
Purity: >99.00%
Supply Ability: 5g
Release date: 2024-03-26

1119249-30-7, Propargyl-PEG3-TosRelated Search:

Propargyl-PEG4-S-PEG4-t-butyl ester Azido-PEG4-CH2CO2H Propargyl-PEG4-sulfonic acid Propargyl-PEG4-acid Propargyl-PEG4-S-PEG4-Propargyl Propargyl-PEG4-Sulfone-PEG4-t-butyl ester Propargyl-PEG4-S-PEG4-acid Propargyl-PEG4-bromide Propargyl-PEG4-t-butyl ester Propargyl-PEG4-Sulfone-PEG4-acid Propargyl-PEG4-methylamine Propargyl-PEG4-thiol

Propargyl-PEG3-Tos

2-[2-(prop-2-yn-1-yloxy)ethoxy]ethyl 4-methylbenzene-1-sulfonate

Ethanol, 2-[2-(2-propyn-1-yloxy)ethoxy]-, 1-(4-methylbenzenesulfonate)

2-(2-prop-2-ynoxyethoxy)ethyl 4-methylbenzenesulfonate

1119249-30-7