Propargyl-PEG2-methylamine
- Product Name
- Propargyl-PEG2-methylamine
- CAS No.
- 1835759-76-6
- Chemical Name
- Propargyl-PEG2-methylamine
- Synonyms
- Propargyl-PEG2-NHMe;Propargyl-PEG2-methylamine;Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]-;Propargyl-PEG2-NHMe/Ethanamine, N-methyl-2-[2-(2-propyn-1-yloxy)ethoxy]-
- CBNumber
- CB03062618
- Molecular Formula
- C8H15NO2
- Formula Weight
- 157.21
- MOL File
- 1835759-76-6.mol
Propargyl-PEG2-methylamine Property
- Boiling point:
- 214.6±20.0 °C(Predicted)
- Density
- 0.947±0.06 g/cm3(Predicted)
- solubility
- Soluble in Water, DMSO, DCM, DMF
- pka
- 9.50±0.10(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P280Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BP-22929
- Product name
- Propargyl-PEG2-methylamine
- Purity
- 98%
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- BP-22929
- Product name
- Propargyl-PEG2-methylamine
- Purity
- 98%
- Packaging
- 500mg
- Price
- $750
- Updated
- 2021/12/16
- Product number
- B-1378
- Product name
- Propargyl-PEG2-NHMe
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $146.7
- Updated
- 2021/12/16
Propargyl-PEG2-methylamine Chemical Properties,Usage,Production
Description
Propargyl-PEG2-methylamine is a crosslinker with a propargyl group and methylamine group. The propargyl group forms triazole linkage with azide-bearing compounds or biomolecules in copper catalyzed Click Chemistry reactions. The methylamine group is reactive with carboxylic acids, activated NHS esters, carbonyls (ketone, aldehyde) etc.
Uses
Propargyl-PEG2-methylamine (Propargyl-PEG2-NHMe) is a PEG derivative containing a propargyl group and methylamine group. Propargyl-PEG2-methylamine is an PROTAC linker used in the synthesis of PROTACs. Propargyl-PEG2-methylamine is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups[1].
References
[1] Wurz RP, et al. A "Click Chemistry Platform" for the Rapid Synthesis of Bispecific Molecules for Inducing Protein Degradation. J Med Chem. 2018 Jan 25;61(2):453-461. DOI:10.1021/acs.jmedchem.6b01781
Propargyl-PEG2-methylamine Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Propargyl-PEG2-methylamine manufacturers
- Product
- Propargyl-PEG2-methylamine 1835759-76-6
- Price
- US $0.00/mg
- Min. Order
- 500mg
- Purity
- >98.00%
- Supply Ability
- 500mg
- Release date
- 2024-03-26