Aminooxy-PEG1-propargyl
- Product Name
- Aminooxy-PEG1-propargyl
- CAS No.
- 1895922-69-6
- Chemical Name
- Aminooxy-PEG1-propargyl
- Synonyms
- Aminooxy-PEG1-propargyl;Aminooxy-PEG1-propargyl HCl salt;O-(2-(Prop-2-yn-1-yloxy)ethyl)hydroxylamine;Hydroxylamine, O-[2-(2-propyn-1-yloxy)ethyl]-
- CBNumber
- CB33162830
- Molecular Formula
- C5H9NO2
- Formula Weight
- 115.13
- MOL File
- 1895922-69-6.mol
Aminooxy-PEG1-propargyl Property
- Boiling point:
- 212.1±20.0 °C(Predicted)
- Density
- 1.035±0.06 g/cm3(Predicted)
- storage temp.
- 2-8°C, protect from light, stored under nitrogen
- solubility
- Soluble in Water, DMSO, DMF
- form
- Liquid
- pka
- 4.09±0.70(Predicted)
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H314Causes severe skin burns and eye damage
H332Harmful if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P363Wash contaminated clothing before reuse.
P370+P378In case of fire: Use … for extinction.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- 1975EG
- Product name
- Aminooxy-PEG1-propargylHClsalt
- Packaging
- 100mg
- Price
- $407
- Updated
- 2021/12/16
- Product number
- BP-23164
- Product name
- Aminooxy-PEG1-propargylHClsalt
- Purity
- 98%
- Packaging
- 1g
- Price
- $1250
- Updated
- 2021/12/16
Aminooxy-PEG1-propargyl Chemical Properties,Usage,Production
Description
Aminooxy-PEG1-propargyl is a click chemistry PEG linker containing a propargyl group and an aminooxy group. The aminooxy group is reactive with an aldehyde or ketone group to form a stable oxime linkage. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage. Aminooxy compounds are very reactive and sensitive; they cannot be stored for long term. Immediate use (within 1 week) is highly recommended.
Uses
Aminooxy-PEG1-propargyl is a PEG-based PROTAC linker can be used in the synthesis of PROTACs[1]. Aminooxy-PEG1-propargyl is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
PEGs
References
[1] Zhang F, et al. Discovery of a new class of PROTAC BRD4 degraders based on a dihydroquinazolinone derivative and lenalidomide/pomalidomide. Bioorg Med Chem. 2020 Jan 1;28(1):115228. DOI:10.1016/j.bmc.2019.115228
Aminooxy-PEG1-propargyl Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Aminooxy-PEG1-propargyl manufacturers
- Product
- Aminooxy-PEG1-propargyl HCl salt 1895922-69-6
- Price
- US $0.00/g
- Min. Order
- 10g
- Purity
- >98.00%
- Supply Ability
- 10g
- Release date
- 2024-03-22