Propargyl-PEG8-acid
- Product Name
- Propargyl-PEG8-acid
- CAS No.
- 2055014-94-1
- Chemical Name
- Propargyl-PEG8-acid
- Synonyms
- CAS_2055014-94-1;Propargyl-PEG8-acid;Propargyl-PEG7-C2-COOH;Propargyl-PEG7-CH2CH2COOH;4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid;Propargyl-PEG7-CH2CH2COOH/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid;3-[2-[2-[2-[2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]ethoxy]propanoic acid
- CBNumber
- CB83134214
- Molecular Formula
- C20H36O10
- Formula Weight
- 436.49
- MOL File
- 2055014-94-1.mol
Propargyl-PEG8-acid Property
- storage temp.
- -20°C, stored under nitrogen
- solubility
- Soluble in Water, DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-22811
- Product name
- Propargyl-PEG8-acid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- BP-22811
- Product name
- Propargyl-PEG8-acid
- Purity
- 98%
- Packaging
- 250mg
- Price
- $490
- Updated
- 2021/12/16
- Product number
- AS104186
- Product name
- Propargyl-PEG7-CH2CH2COOH
- Purity
- 95+%
- Packaging
- 1g
- Price
- $588
- Updated
- 2021/12/16
- Product number
- BIPG1709
- Product name
- Propargyl-PEG8-acid
- Packaging
- 100mg
- Price
- $623
- Updated
- 2021/12/16
- Product number
- CS-0107562
- Product name
- Propargyl-PEG8-acid
- Packaging
- 1g
- Price
- $1340
- Updated
- 2021/12/16
Propargyl-PEG8-acid Chemical Properties,Usage,Production
Description
Propargyl-PEG8-acid has an alkyne group and an acid group. The acid group can derivatize amine-containing molecules in the presence of activators such as EDC or HATU. The alkyne group can react with azides via copper catalyzed Click Chemistry reactions. The PEG units help increase the solubility of the molecule in aqueous environment.
Uses
Propargyl-PEG8-acid is a PEG-based PROTAC linker can be used in the synthesis of PROTACs. Propargyl-PEG8-acid is a cleavable ADC linker used in the synthesis of antibody-drug conjugates (ADCs). The ADCs can be used in bacterial infections caused by Gram-negative bacteria[1]. Propargyl-PEG8-acid is a click chemistry reagent, it contains an Alkyne group and can undergo copper-catalyzed azide-alkyne cycloaddition (CuAAc) with molecules containing Azide groups.
IC 50
Cleavable Linker; PEGs
References
[1] Suzanne AKERS-RODRIGUEZ, et al. Compositions and methods for the treatment of bacterial infections. WO2019126353A2.
Propargyl-PEG8-acid Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG8-acid Suppliers
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View Lastest Price from Propargyl-PEG8-acid manufacturers
- Product
- Propargyl-PEG7-CH2CH2COOH 2055014-94-1
- Price
- US $573.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 300kg
- Release date
- 2025-11-24
- Product
- Propargyl-PEG8-acid 2055014-94-1
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-26