Propargyl-PEG4-Tos
- Product Name
- Propargyl-PEG4-Tos
- CAS No.
- 875770-32-4
- Chemical Name
- Propargyl-PEG4-Tos
- Synonyms
- Propargyl-PEG5-Tos;Propargyl-PEG4-Tos;3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate;3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate)
- CBNumber
- CB53062628
- Molecular Formula
- C18H26O7S
- Formula Weight
- 386.46
- MOL File
- 875770-32-4.mol
Propargyl-PEG4-Tos Property
- Boiling point:
- 498.1±45.0 °C(Predicted)
- Density
- 1.177±0.06 g/cm3(Predicted)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- P8651
- Product name
- Propargyl-PEG5-Tos
- Purity
- 95%
- Packaging
- 50mg
- Price
- $180
- Updated
- 2021/12/16
- Product number
- P8651
- Product name
- Propargyl-PEG5-Tos
- Purity
- 95%
- Packaging
- 100mg
- Price
- $280
- Updated
- 2021/12/16
- Product number
- P8651
- Product name
- Propargyl-PEG5-Tos
- Purity
- 95%
- Packaging
- 250mg
- Price
- $380
- Updated
- 2021/12/16
- Product number
- BP-22781
- Product name
- Propargyl-PEG5-Tos
- Purity
- 98%
- Packaging
- 250mg
- Price
- $450
- Updated
- 2021/12/16
- Product number
- P8651
- Product name
- Propargyl-PEG5-Tos
- Purity
- 95%
- Packaging
- 500mg
- Price
- $580
- Updated
- 2021/12/16
Propargyl-PEG4-Tos Chemical Properties,Usage,Production
Description
Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.
Biological Activity
Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| PEGs
| Cleavable
|