Propargyl-PEG4-Tos

Product Name: Propargyl-PEG4-Tos
CAS No.: 875770-32-4
Chemical Name: Propargyl-PEG4-Tos
Synonyms: Propargyl-PEG5-Tos;Propargyl-PEG4-Tos;3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate;3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate);2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
CBNumber: CB53062628
Molecular Formula: C18H26O7S
Formula Weight: 386.46
MOL File: 875770-32-4.mol

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Propargyl-PEG4-Tos Property

Boiling point:: 498.1±45.0 °C(Predicted)
Density: 1.177±0.06 g/cm3(Predicted)
form: Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Synthonix

Product number: P8651
Product name: Propargyl-PEG5-Tos
Purity: 95%
Packaging: 50mg
Price: $180
Updated: 2021/12/16

Synthonix

Product number: P8651
Product name: Propargyl-PEG5-Tos
Purity: 95%
Packaging: 100mg
Price: $280
Updated: 2021/12/16

Synthonix

Product number: P8651
Product name: Propargyl-PEG5-Tos
Purity: 95%
Packaging: 250mg
Price: $380
Updated: 2021/12/16

BroadPharm

Product number: BP-22781
Product name: Propargyl-PEG5-Tos
Purity: 98%
Packaging: 250mg
Price: $450
Updated: 2021/12/16

Synthonix

Product number: P8651
Product name: Propargyl-PEG5-Tos
Purity: 95%
Packaging: 500mg
Price: $580
Updated: 2021/12/16

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Propargyl-PEG4-Tos Chemical Properties,Usage,Production

Description

Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Biological Activity

Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Propargyl-PEG4-Tos Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG4-Tos Suppliers

China 43 United Kingdom 1 United States 5 Global 49

Daicel Chiral Technologies (China)CO.,LTD

Tel: 021-50460086-9 15921403865
Fax: +86-21-50462321
Email: han_yajun@dctc.daicel.com
Country: China
ProdList: 6577
Advantage: 65

Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 41457
Advantage: 60

Borenpharm Co., Ltd

Tel: 027-65563561
Fax: 86-27-59218822
Email: sales@borenpharm.com
Country: China
ProdList: 1245
Advantage: 55

Jinan elephant international trading co., LTD

Tel
Fax: -
Email: 13006575422@163.com
Country: China
ProdList: 6355
Advantage: 58

Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
Country: China
ProdList: 12306
Advantage: 58

Xi'an Confluore Biological Technology Co., Ltd.

Tel: +86-156-80926068 +86-15680926068
Email: 1924344760@qq.com
Country: China
ProdList: 4825
Advantage: 58

Shanghai Moss Medicine Technology Co., Ltd.

Tel: +86-188369842 +86-15618151133
Fax: QQ188369842
Email: 188369842@qq.com
Country: China
ProdList: 1943
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
Advantage: 58

Hangzhou Huarong Pharm Co., Ltd.

Tel: 571-86758373 +8613588754946
Fax: 0086-571-81131109
Email: sales@huarongpharm.com
Country: CHINA
ProdList: 3148
Advantage: 58

Wuhan Borenpharm Co., Ltd

Tel: 027-65563561 18717150066
Fax: 027-59218822
Email: 3207347307@qq.com
Country: CHINA
ProdList: 1238
Advantage: 58

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View Lastest Price from Propargyl-PEG4-Tos manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG5-Tos 875770-32-4
Price: US $0.00/g
Min. Order: 5g
Purity: >95.00%
Supply Ability: 5g
Release date: 2024-03-26

875770-32-4, Propargyl-PEG4-TosRelated Search:

Propargyl-PEG5-t-butyl ester 2-[2-(2-Propyn-1-yloxy)ethoxy]acetic acid Polyethylene Glycol POLY(ETHYLENE GLYCOL) METHYL ETHER METHACRYLATE Propargyl-PEG9-bromide Propargyl-PEG8-acid Propargyl-PEG8-bromide Propargyl-PEG7-t-butyl ester Propargyl-PEG8-NHS ester Propargyl-PEG6-acid Propargyl-PEG8-t-butyl ester Propargyl-PEG6-t-butyl ester Propargyl-PEG7-acid Propargyl-PEG8-alcohol t-Boc-N-Amido-PEG2-Propargyl 2,5-dioxopyrrolidin-1-yl pent-4-ynoate MPEGn-Alkyne 2K, 5K, 10K, 20K Propargyl-PEG6-Tos

3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate

Propargyl-PEG4-Tos

Propargyl-PEG5-Tos

3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate)

2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate

875770-32-4

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PEGs

Cleavable