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Propargyl-PEG4-Tos

Product Name
Propargyl-PEG4-Tos
CAS No.
875770-32-4
Chemical Name
Propargyl-PEG4-Tos
Synonyms
Propargyl-PEG5-Tos;Propargyl-PEG4-Tos;3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate;3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate);2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
CBNumber
CB53062628
Molecular Formula
C18H26O7S
Formula Weight
386.46
MOL File
875770-32-4.mol
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Propargyl-PEG4-Tos Property

Boiling point:
498.1±45.0 °C(Predicted)
Density 
1.177±0.06 g/cm3(Predicted)
form 
Liquid
color 
Colorless to light yellow
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Synthonix
Product number
P8651
Product name
Propargyl-PEG5-Tos
Purity
95%
Packaging
50mg
Price
$180
Updated
2021/12/16
Synthonix
Product number
P8651
Product name
Propargyl-PEG5-Tos
Purity
95%
Packaging
100mg
Price
$280
Updated
2021/12/16
Synthonix
Product number
P8651
Product name
Propargyl-PEG5-Tos
Purity
95%
Packaging
250mg
Price
$380
Updated
2021/12/16
BroadPharm
Product number
BP-22781
Product name
Propargyl-PEG5-Tos
Purity
98%
Packaging
250mg
Price
$450
Updated
2021/12/16
Synthonix
Product number
P8651
Product name
Propargyl-PEG5-Tos
Purity
95%
Packaging
500mg
Price
$580
Updated
2021/12/16
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Propargyl-PEG4-Tos Chemical Properties,Usage,Production

Description

Propargyl-PEG5-Tos is a PEG linker containing a tosyl group and a propargyl group. The hydrophilic PEG spacer increases solubility in aqueous media. The tosyl group is a very good leaving group for nucleophilic substitution reactions. The propargyl group can react with azide-bearing compounds or biomolecules via copper catalyzed azide-alkyne Click Chemistry to yield a stable triazole linkage.

Biological Activity

Propargyl-PEG4-Tos is a PROTAC linker belonging to the PEG class and can be used to synthesize a series of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody-drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Propargyl-PEG4-Tos Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG4-Tos Suppliers

Tel
021-50460086-9 15921403865
Fax
+86-21-50462321
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han_yajun@dctc.daicel.com
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China
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400-164-7117 13681763483
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+86-21-61629029
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product02@bidepharm.com
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China
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Tel
027-65563561
Fax
86-27-59218822
Email
sales@borenpharm.com
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China
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Fax
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13006575422@163.com
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China
ProdList
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010-60605840 18892239720
Fax
010-60605840
Email
psaitong@jm-bio.com
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China
ProdList
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+86-156-80926068 +86-15680926068
Email
1924344760@qq.com
Country
China
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+86-188369842 +86-15618151133
Fax
QQ188369842
Email
188369842@qq.com
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China
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+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
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Tel
571-86758373 +8613588754946
Fax
0086-571-81131109
Email
sales@huarongpharm.com
Country
CHINA
ProdList
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58
Tel
027-65563561 18717150066
Fax
027-59218822
Email
3207347307@qq.com
Country
CHINA
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View Lastest Price from Propargyl-PEG4-Tos manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Propargyl-PEG5-Tos 875770-32-4
Price
US $0.00/g
Min. Order
5g
Purity
>95.00%
Supply Ability
5g
Release date
2024-03-26

875770-32-4, Propargyl-PEG4-TosRelated Search:


  • 3,6,9,12-tetraoxapentadec-14-yn-1-yl 4-methylbenzene-1-sulfonate
  • Propargyl-PEG4-Tos
  • Propargyl-PEG5-Tos
  • 3,6,9,12-Tetraoxapentadec-14-yn-1-ol, 1-(4-methylbenzenesulfonate)
  • 2-[2-[2-(2-prop-2-ynoxyethoxy)ethoxy]ethoxy]ethyl 4-methylbenzenesulfonate
  • 875770-32-4
  • PEGs

    Cleavable