Propargyl-PEG8-NHS ester
- Product Name
- Propargyl-PEG8-NHS ester
- CAS No.
- 2182601-74-5
- Chemical Name
- Propargyl-PEG8-NHS ester
- Synonyms
- Alkyne-PEG8-NHS;Propargyl-PEG8-NHS;Propargyl-PEG8-NHS ester;Propargyl-PEG7-CH2CH2COONHS;Propargyl-PEG7-C2-CONHS ester;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate;4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB24849485
- Molecular Formula
- C24H39NO12
- Formula Weight
- 533.57
- MOL File
- 2182601-74-5.mol
Propargyl-PEG8-NHS ester Property
- Boiling point:
- 593.4±60.0 °C(Predicted)
- Density
- 1.21±0.1 g/cm3(Predicted)
- storage temp.
- Storage temp. -20°C
- solubility
- Soluble in DCM
- form
- Viscous Liquid
- color
- Colorless to light yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P330Rinse mouth.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- BP-23778
- Product name
- Propargyl-PEG8-NHSester
- Purity
- 98%
- Packaging
- 100mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- AS107809
- Product name
- Propargyl-PEG7-CH2CH2COONHS
- Purity
- 97%
- Packaging
- 250mg
- Price
- $454
- Updated
- 2021/12/16
- Product number
- BP-23778
- Product name
- Propargyl-PEG8-NHSester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $720
- Updated
- 2021/12/16
- Product number
- B-1545
- Product name
- Propargyl-PEG7-CH2CH2COONHS
- Purity
- 97%
- Packaging
- 0.25g
- Price
- $315.33
- Updated
- 2021/12/16
Propargyl-PEG8-NHS ester Chemical Properties,Usage,Production
Description
Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.
Biological Activity
Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
| Cleavable
| PEGs
| Alkyl/ether
|
Propargyl-PEG8-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG8-NHS ester Suppliers
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View Lastest Price from Propargyl-PEG8-NHS ester manufacturers
- Product
- Propargyl-PEG8-NHS 2182601-74-5
- Price
- US $0.00-0.00/g
- Min. Order
- 1g
- Purity
- 98%
- Supply Ability
- 1g/bottle, 10g/bottle, 100g/bottle
- Release date
- 2026-02-03
- Product
- Propargyl-PEG8-NHS ester 2182601-74-5
- Price
- US $0.00/g
- Min. Order
- 1g
- Purity
- >98.00%
- Supply Ability
- 1g
- Release date
- 2024-03-26