3-(2-Propynyloxy)propanoic acid
- Product Name
- 3-(2-Propynyloxy)propanoic acid
- CAS No.
- 55683-37-9
- Chemical Name
- 3-(2-Propynyloxy)propanoic acid
- Synonyms
- Propargyl-PEG1-Acid;3-(Prop-2-yn-1-yloxy)propanoic acid;Alkyne-PEG1-COOH;Propargyl-PEG1-acid >=95%;3-prop-2-ynoxypropanoicaci;3-prop-2-ynoxypropanoic acid;Propargyl-PEG1-acid;3-(2-Propynyloxy)propanoic acid;3-(prop-2-ynyloxy)propanoic acid;3-(2-Propyn-1-yloxy)propanoic acid
- CBNumber
- CB52175752
- Molecular Formula
- C6H8O3
- Formula Weight
- 128.13
- MOL File
- 55683-37-9.mol
3-(2-Propynyloxy)propanoic acid Property
- Boiling point:
- 265.8±20.0 °C(Predicted)
- Density
- 1.140±0.06 g/cm3(Predicted)
- storage temp.
- -20°C
- pka
- 4.19±0.10(Predicted)
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C6H8O3/c1-2-4-9-5-3-6(7)8/h1H,3-5H2,(H,7,8)
- InChIKey
- GMFDYXLFHSFUHE-UHFFFAOYSA-N
- SMILES
- C(O)(=O)CCOCC#C
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 901567
- Product name
- Propargyl-PEG1-acid
- Purity
- ≥95%
- Packaging
- 50MG
- Price
- $99.36
- Updated
- 2025/07/31
- Product number
- P839730
- Product name
- 3-(Prop-2-ynyloxy)propanoicAcid
- Packaging
- 10mg
- Price
- $45
- Updated
- 2021/12/16
- Product number
- BP-21981
- Product name
- Propargyl-PEG1-acid
- Purity
- 98%
- Packaging
- 100mg
- Price
- $120
- Updated
- 2021/12/16
- Product number
- 6811BA
- Product name
- 3-(Prop-2-yn-1-yloxy)propanoicacid
- Packaging
- 100mg
- Price
- $143
- Updated
- 2021/12/16
- Product number
- AS116781
- Product name
- 3-(Prop-2-yn-1-yloxy)propanoicacid
- Purity
- 97+%
- Packaging
- 250mg
- Price
- $210
- Updated
- 2021/12/16
3-(2-Propynyloxy)propanoic acid Chemical Properties,Usage,Production
Description
Propargyl-PEG1-acid is a crosslinker with a propargyl group and a carboxylic acid group. The carboxylic acid reacts with primary amine under the activation of HATU or EDC. The propargyl group can participate in copper catalyzed azide-alkyne Click Chemistry reactions.
Uses
This is a crosslinker with an alkyne group on one end and a carboxyl group on the other end. The alkyne can be used to attach to an azide using copper-catalyzed click chemistry. The compound contains a single PEG unit to help improve solubility.
reaction suitability
reagent type: linker
Synthesis
488150-84-1
55683-37-9
General procedure for the synthesis of propargyl-monoethylene glycol-carboxylic acid from tert-butyl 3-(prop-2-yn-1-yloxy)propionate: trifluoroacetic acid (8.065 mL, 108.6 mmol) was added to a solution of tert-butyl 3-(prop-2-yn-1-yloxy)propionate (2.0 g, 10.86 mmol) in dichloromethane (50 mL). The reaction mixture was stirred overnight at room temperature and subsequently concentrated under vacuum, co-evaporated with toluene and purified by fast chromatography on 80 g silica gel (using a dichloromethane/methanol gradient elution) to afford 1.1 g of propargyl-monoethyleneglycol-carboxylic acid as an oil (80% yield).1H NMR (400 MHz, DMSO-d6, δ, ppm): 2.46 (t J = 6.4 Hz, 2H); 3.43 (t, J = 2.4 Hz, 1H); 3.63 (t, J = 6.4 Hz, 2H); 4.11 (d, J = 2.4 Hz, 2H); 12.20 (broad peak, 1H).
IC 50
PEGs
References
[1] Patent: WO2017/76998, 2017, A1. Location in patent: Page/Page column 222-223
[2] Israel Journal of Chemistry, 2001, vol. 41, # 4, p. 283 - 295
3-(2-Propynyloxy)propanoic acid Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 3-(2-Propynyloxy)propanoic acid manufacturers
- Product
- Propargyl-PEG1-acid 55683-37-9
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-26