Propargyl-PEG3-NHS ester

Product Name: Propargyl-PEG3-NHS ester
CAS No.: 1428629-71-3
Chemical Name: Propargyl-PEG3-NHS ester
Synonyms: Alkyne-PEG3-NHS;Propargyl-PEG2-Osu;Propargyl-PEG3-NHS ester;Propargyl-PEG2-CH2CH2COONHS;Propargyl-PEG2-C2-CONHS ester;(2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate;2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate;Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB13049421
Molecular Formula: C14H19NO7
Formula Weight: 313.3
MOL File: 1428629-71-3.mol

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Propargyl-PEG3-NHS ester Property

Boiling point:: 427.2±55.0 °C(Predicted)
Density: 1.26±0.1 g/cm3(Predicted)
solubility: Soluble in DMSO, DCM, DMF
form: Liquid
color: Colorless to light yellow
InChI: InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2
InChIKey: YDRPXORAOIYIGV-UHFFFAOYSA-N
SMILES: C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCC#C

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Safety

HS Code: 2942000090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC

Product number: P839588
Product name: Propargyl-PEG3-NHSester
Packaging: 10mg
Price: $65
Updated: 2021/12/16

TRC

Product number: P839588
Product name: Propargyl-PEG3-NHSester
Packaging: 50mg
Price: $220
Updated: 2021/12/16

TRC

Product number: P839588
Product name: Propargyl-PEG3-NHSester
Packaging: 100mg
Price: $350
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: POL0002522
Product name: PROPARGYL-PEG3-NHS ESTER
Purity: 95.00%
Packaging: 100MG
Price: $236.25
Updated: 2021/12/16

BroadPharm

Product number: BP-21613
Product name: Propargyl-PEG3-NHSester
Purity: 98%
Packaging: 500mg
Price: $560
Updated: 2021/12/16

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Propargyl-PEG3-NHS ester Chemical Properties,Usage,Production

Description

Propargyl-PEG3-NHS ester is a Click Chemistry reagent with a propargyl group and an NHS ester group. The propargyl group can react with biomolecules containing azide group via copper catalyzed Click Chemistry reaction. The NHS ester is an amine reactive group which can be used for derivatizing peptides, antibodies, amine coated surfaces etc.

Biological Activity

Propargyl-PEG3-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Propargyl-PEG3-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG3-NHS ester Suppliers

China 55 India 1 United Kingdom 1 United States 5 Global 62

Chengdu Pukang Biotechnology Co., Ltd

Tel: 028-82550498 19102685862
Fax: 086-28-82550468
Email: sales@pu-kang.com
Country: China
ProdList: 485
Advantage: 58

T&W GROUP

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Fax: ＋86 21-50676805
Email: contact@trustwe.com
Country: China
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Bide Pharmatech Ltd.

Tel: 400-164-7117 13681763483
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Country: China
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Hunan HuaTeng Pharmaceutical Co., Ltd.,

Tel: 400-8592883 15367835770
Fax: 0731-82251112
Email: viola@huatengsci.com
Country: China
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Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.

Tel: 025-66113011 18112977050
Email: cb6@aikonchem.com
Country: China
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Jilin Chinese Academy of Sciences - Yanshen Technology Co., Ltd

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Country: China
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Borenpharm Co., Ltd

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Zhengzhou Acme Chemical Co., Ltd.

Tel: 0371-0371-55629727 13323845623
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Beijing Jin Ming Biotechnology Co., Ltd.

Tel: 010-60605840 18892239720
Fax: 010-60605840
Email: psaitong@jm-bio.com
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Amatek Scientific Co. Ltd.

Tel: 0512-56316828
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Email: info@amateksci.com
Country: China
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View Lastest Price from Propargyl-PEG3-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG3-NHS ester 1428629-71-3
Price: US $0.00/g
Min. Order: 5g
Purity: >98.00%
Supply Ability: 5g
Release date: 2024-03-26

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Propargyl-PEG3-NHS ester

Alkyne-PEG3-NHS

Propargyl-PEG2-CH2CH2COONHS

Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester

2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate

Propargyl-PEG2-Osu

Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester

Propargyl-PEG2-C2-CONHS ester

(2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate

1428629-71-3

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