Propargyl-PEG3-NHS ester
- Product Name
- Propargyl-PEG3-NHS ester
- CAS No.
- 1428629-71-3
- Chemical Name
- Propargyl-PEG3-NHS ester
- Synonyms
- Alkyne-PEG3-NHS;Propargyl-PEG2-Osu;Propargyl-PEG3-NHS ester;Propargyl-PEG2-CH2CH2COONHS;Propargyl-PEG2-C2-CONHS ester;(2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate;2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate;Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
- CBNumber
- CB13049421
- Molecular Formula
- C14H19NO7
- Formula Weight
- 313.3
- MOL File
- 1428629-71-3.mol
Propargyl-PEG3-NHS ester Property
- Boiling point:
- 427.2±55.0 °C(Predicted)
- Density
- 1.26±0.1 g/cm3(Predicted)
- solubility
- Soluble in DMSO, DCM, DMF
- form
- Liquid
- color
- Colorless to light yellow
- InChI
- InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2
- InChIKey
- YDRPXORAOIYIGV-UHFFFAOYSA-N
- SMILES
- C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCC#C
Safety
- HS Code
- 2942000090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- P839588
- Product name
- Propargyl-PEG3-NHSester
- Packaging
- 10mg
- Price
- $65
- Updated
- 2021/12/16
- Product number
- P839588
- Product name
- Propargyl-PEG3-NHSester
- Packaging
- 50mg
- Price
- $220
- Updated
- 2021/12/16
- Product number
- P839588
- Product name
- Propargyl-PEG3-NHSester
- Packaging
- 100mg
- Price
- $350
- Updated
- 2021/12/16
- Product number
- POL0002522
- Product name
- PROPARGYL-PEG3-NHS ESTER
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $236.25
- Updated
- 2021/12/16
- Product number
- BP-21613
- Product name
- Propargyl-PEG3-NHSester
- Purity
- 98%
- Packaging
- 500mg
- Price
- $560
- Updated
- 2021/12/16
Propargyl-PEG3-NHS ester Chemical Properties,Usage,Production
Description
Propargyl-PEG3-NHS ester is a Click Chemistry reagent with a propargyl group and an NHS ester group. The propargyl group can react with biomolecules containing azide group via copper catalyzed Click Chemistry reaction. The NHS ester is an amine reactive group which can be used for derivatizing peptides, antibodies, amine coated surfaces etc.
Biological Activity
Propargyl-PEG3-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).
in vitro
PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.
target
Cleavable
| PEGs
| Alkyl/ether
|
Propargyl-PEG3-NHS ester Preparation Products And Raw materials
Raw materials
Preparation Products
Propargyl-PEG3-NHS ester Suppliers
- Tel
- 028-82550498 19102685862
- Fax
- 086-28-82550468
- sales@pu-kang.com
- Country
- China
- ProdList
- 485
- Advantage
- 58
- Tel
- 021-61551611 13296011611
- Fax
- +86 21-50676805
- contact@trustwe.com
- Country
- China
- ProdList
- 9895
- Advantage
- 58
- Tel
- 400-164-7117 13681763483
- Fax
- +86-21-61629029
- product02@bidepharm.com
- Country
- China
- ProdList
- 41462
- Advantage
- 60
- Tel
- 400-8592883 15367835770
- Fax
- 0731-82251112
- viola@huatengsci.com
- Country
- China
- ProdList
- 5873
- Advantage
- 58
- Tel
- 025-66113011 18112977050
- cb6@aikonchem.com
- Country
- China
- ProdList
- 16684
- Advantage
- 50
- Tel
- 0431-0431-80514535 19917294565
- et@chemextension.com
- Country
- China
- ProdList
- 3980
- Advantage
- 55
- Tel
- 027-65563561
- Fax
- 86-27-59218822
- sales@borenpharm.com
- Country
- China
- ProdList
- 1245
- Advantage
- 55
- Tel
- 0371-0371-55629727 13323845623
- Fax
- 037155629727
- 2885676761@qq.com
- Country
- China
- ProdList
- 9996
- Advantage
- 58
- Tel
- 010-60605840 18892239720
- Fax
- 010-60605840
- psaitong@jm-bio.com
- Country
- China
- ProdList
- 12306
- Advantage
- 58
- Tel
- 0512-56316828
- Fax
- 0512-56316826
- info@amateksci.com
- Country
- China
- ProdList
- 28806
- Advantage
- 58
View Lastest Price from Propargyl-PEG3-NHS ester manufacturers
- Product
- Propargyl-PEG3-NHS ester 1428629-71-3
- Price
- US $0.00/g
- Min. Order
- 5g
- Purity
- >98.00%
- Supply Ability
- 5g
- Release date
- 2024-03-26