ChemicalBook > CAS DataBase List > Propargyl-PEG3-NHS ester

Propargyl-PEG3-NHS ester

Product Name
Propargyl-PEG3-NHS ester
CAS No.
1428629-71-3
Chemical Name
Propargyl-PEG3-NHS ester
Synonyms
Alkyne-PEG3-NHS;Propargyl-PEG2-Osu;Propargyl-PEG3-NHS ester;Propargyl-PEG2-CH2CH2COONHS;Propargyl-PEG2-C2-CONHS ester;(2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate;2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate;Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber
CB13049421
Molecular Formula
C14H19NO7
Formula Weight
313.3
MOL File
1428629-71-3.mol
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Propargyl-PEG3-NHS ester Property

Boiling point:
427.2±55.0 °C(Predicted)
Density 
1.26±0.1 g/cm3(Predicted)
solubility 
Soluble in DMSO, DCM, DMF
form 
Liquid
color 
Colorless to light yellow
InChI
InChI=1S/C14H19NO7/c1-2-6-19-8-10-21-11-9-20-7-5-14(18)22-15-12(16)3-4-13(15)17/h1H,3-11H2
InChIKey
YDRPXORAOIYIGV-UHFFFAOYSA-N
SMILES
C(ON1C(=O)CCC1=O)(=O)CCOCCOCCOCC#C
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Safety

HS Code 
2942000090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
P839588
Product name
Propargyl-PEG3-NHSester
Packaging
10mg
Price
$65
Updated
2021/12/16
TRC
Product number
P839588
Product name
Propargyl-PEG3-NHSester
Packaging
50mg
Price
$220
Updated
2021/12/16
TRC
Product number
P839588
Product name
Propargyl-PEG3-NHSester
Packaging
100mg
Price
$350
Updated
2021/12/16
American Custom Chemicals Corporation
Product number
POL0002522
Product name
PROPARGYL-PEG3-NHS ESTER
Purity
95.00%
Packaging
100MG
Price
$236.25
Updated
2021/12/16
BroadPharm
Product number
BP-21613
Product name
Propargyl-PEG3-NHSester
Purity
98%
Packaging
500mg
Price
$560
Updated
2021/12/16
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Propargyl-PEG3-NHS ester Chemical Properties,Usage,Production

Description

Propargyl-PEG3-NHS ester is a Click Chemistry reagent with a propargyl group and an NHS ester group. The propargyl group can react with biomolecules containing azide group via copper catalyzed Click Chemistry reaction. The NHS ester is an amine reactive group which can be used for derivatizing peptides, antibodies, amine coated surfaces etc.

Biological Activity

Propargyl-PEG3-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. It is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Propargyl-PEG3-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG3-NHS ester Suppliers

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View Lastest Price from Propargyl-PEG3-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.
Product
Propargyl-PEG3-NHS ester 1428629-71-3
Price
US $0.00/g
Min. Order
5g
Purity
>98.00%
Supply Ability
5g
Release date
2024-03-26

1428629-71-3, Propargyl-PEG3-NHS esterRelated Search:


  • Propargyl-PEG3-NHS ester
  • Alkyne-PEG3-NHS
  • Propargyl-PEG2-CH2CH2COONHS
  • Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
  • 2,5-Dioxopyrrolidin-1-yl 3-(2-(2-(prop-2-yn-1-yloxy)ethoxy)ethoxy)propanoate
  • Propargyl-PEG2-Osu
  • Propargyl-PEG2-CH2CH2COONHS/Propanoic acid, 3-[2-[2-(2-propyn-1-yloxy)ethoxy]ethoxy]-, 2,5-dioxo-1-pyrrolidinyl ester
  • Propargyl-PEG2-C2-CONHS ester
  • (2,5-dioxopyrrolidin-1-yl) 3-[2-(2-prop-2-ynoxyethoxy)ethoxy]propanoate
  • 1428629-71-3
  • peg