Propargyl-PEG8-NHS ester

Product Name: Propargyl-PEG8-NHS ester
CAS No.: 2182601-74-5
Chemical Name: Propargyl-PEG8-NHS ester
Synonyms: Propargyl-PEG8-NHS ester;Propargyl-PEG7-CH2CH2COONHS;Propargyl-PEG7-C2-CONHS ester;2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate;4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester;Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester
CBNumber: CB24849485
Molecular Formula: C24H39NO12
Formula Weight: 533.57
MOL File: 2182601-74-5.mol

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Propargyl-PEG8-NHS ester Property

Boiling point:: 593.4±60.0 °C(Predicted)
Density: 1.21±0.1 g/cm3(Predicted)
solubility: Soluble in DCM
form: Viscous Liquid
color: Colorless to light yellow

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

BroadPharm

Product number: BP-23778
Product name: Propargyl-PEG8-NHSester
Purity: 98%
Packaging: 100mg
Price: $320
Updated: 2021/12/16

Activate Scientific

Product number: AS107809
Product name: Propargyl-PEG7-CH2CH2COONHS
Purity: 97%
Packaging: 250mg
Price: $454
Updated: 2021/12/16

BroadPharm

Product number: BP-23778
Product name: Propargyl-PEG8-NHSester
Purity: 98%
Packaging: 500mg
Price: $720
Updated: 2021/12/16

Acrotein

Product number: B-1545
Product name: Propargyl-PEG7-CH2CH2COONHS
Purity: 97%
Packaging: 0.25g
Price: $315.33
Updated: 2021/12/16

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Propargyl-PEG8-NHS ester Chemical Properties,Usage,Production

Description

Propargyl-PEG8-NHS ester is an amine reactive compound with an alkyne group. The alkyne group reacts with azide-containing biomolecules in Click Chemistry reactions, copper is needed as a catalyst. The hydrophilic PEG units helps the compound to have better solubility in aqueous environment.

Biological Activity

Propargyl-PEG8-NHS ester is a PROTAC bridge, belonging to the PEG class and the Alkyl/ether class. It can be used to synthesize a range of PROTAC molecules. And it is a cleavable ADC linker for the synthesis of antibody drug conjugates (ADCs).

in vitro

PROTACs contain two different ligands connected by a linker; one is a ligand for an E3 ubiquitin ligase and the other is for the target protein. PROTACs exploit the intracellular ubiquitin-proteasome system to selectively degrade target proteins.
ADCs are comprised of an antibody to which is attached an ADC cytotoxin through an ADC linker.

target

Cleavable

PEGs

Alkyl/ether

Propargyl-PEG8-NHS ester Preparation Products And Raw materials

Raw materials

Preparation Products

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Propargyl-PEG8-NHS ester Suppliers

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View Lastest Price from Propargyl-PEG8-NHS ester manufacturers

Xian confluore Biological Technology Co., Ltd.

Product: Propargyl-PEG8-NHS ester 2182601-74-5
Price: US $0.00/g
Min. Order: 1g
Purity: >98.00%
Supply Ability: 1g
Release date: 2024-03-26

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Propargyl-PEG8-NHS ester

Propargyl-PEG7-CH2CH2COONHS

4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester

2,5-Dioxopyrrolidin-1-yl 4,7,10,13,16,19,22,25-octaoxaoctacos-27-yn-1-oate

Propargyl-PEG7-C2-CONHS ester

Propargyl-PEG7-CH2CH2COONHS/4,7,10,13,16,19,22,25-Octaoxaoctacos-27-ynoic acid, 2,5-dioxo-1-pyrrolidinyl ester

2182601-74-5

C24H39NO12