3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
- Product Name
- 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
- CAS No.
- 74885-09-9
- Chemical Name
- 3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE
- Synonyms
- 5-CT;5-CAT;5-carboxamidotryptamine;2-Carboxyamidotryptamine;5-Carboxamide tryptamine;5-Carboxyamidotryptamine;5-CARBOXAMINODOTRYPTAMINE;5-Carboxamidotryptamine, 5-CT;3-(2-Aminoethyl)-1H-indole-5-carboxamide;1H-Indole-5-carboxamide, 3-(2-aminoethyl)-
- CBNumber
- CB5487413
- Molecular Formula
- C11H13N3O
- Formula Weight
- 203.24
- MOL File
- 74885-09-9.mol
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Property
- Boiling point:
- 513.6±35.0 °C(Predicted)
- Density
- 1.293±0.06 g/cm3(Predicted)
- storage temp.
- −20°C
- solubility
- H2O: 10 mg/mL
- form
- solid
- pka
- 16.32±0.30(Predicted)
- color
- white or off-white
- Stability:
- Hygroscopic
N-Bromosuccinimide Price
- Product number
- CHM0075796
- Product name
- 5-CARBOXAMIDOTRYPTAMINE
- Purity
- 95.00%
- Packaging
- 5MG
- Price
- $788.99
- Updated
- 2021/12/16
- Product number
- CHM0075796
- Product name
- 5-CARBOXAMIDOTRYPTAMINE
- Purity
- 95.00%
- Packaging
- 25MG
- Price
- $1351
- Updated
- 2021/12/16
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Chemical Properties,Usage,Production
Uses
5-Carboxamidotryptamine maleate is an agonist of the 5-HT1 receptors.
Definition
ChEBI: 5-carboxamidotryptamine is a member of tryptamines.
in vivo
5-Carboxamidotryptamine (0.03-3 mg/kg i.p. and 0.125-5 μg i.c.v.) causes a dose-dependent reduction in rectal temperature of mice[3].
5-Carboxamidotryptamine (0.1-1 mg/kg; i.p.) reduces rectal temperature in wild type mice but not 5-HT7 receptor knockout mice[3].
5-Carboxamidotryptamine (0.0 1-1 μg/kg; i.v.) causes consistent, dose-related decreases in diastolic blood pressure and carotid arterial vascular resistance and increases in heart rate of cats. In contrast, 5-HT (1-100 μg/kg; i.v.) causes tachycardia but variable and complex effects on diastolic blood pressure and carotid arterial vascular resistance[5].
5-Carboxamidotryptamine does not cause bronchoconstriction in cats. In contrast, 5-HT causes dose-related bronchoconstriction[5].
| Animal Model: | Male Swiss Webster mice (20-25 g)[3] |
| Dosage: | 0.03-3 mg/kg (i.p.) and 0.125-5 μg (i.c.v.) |
| Administration: | i.p. and i.c.v. |
| Result: | Caused dose-dependent reduction in rectal temperature. |
| Animal Model: | 5-HT7 receptor knockout mice (background=50% 129SvEv/50% C57Bl/6J)[3] |
| Dosage: | 0.1-1 mg/kg |
| Administration: | i.p. and i.c.v. |
| Result: | Reduced rectal temperature in wild type but not 5-HT7 receptor knockout mice. |
IC 50
5-HT1A Receptor; 5-HT1B Receptor; 5-HT1D Receptor; 5-HT5A Receptor; 5-HT7 Receptor
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Preparation Products And Raw materials
Raw materials
Preparation Products
3-(2-AMINO-ETHYL)-1H-INDOLE-5-CARBOXYLIC ACID AMIDE Suppliers
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