ChemicalBook > CAS DataBase List > 4-Hydroxy-6-(trifluoromethyl)pyrimidine

4-Hydroxy-6-(trifluoromethyl)pyrimidine

Product Name
4-Hydroxy-6-(trifluoromethyl)pyrimidine
CAS No.
1546-78-7
Chemical Name
4-Hydroxy-6-(trifluoromethyl)pyrimidine
Synonyms
6-TRIFLUOROMETHYL-4-PYRIMIDINOL;6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL;4-PYRIMIDINOL, 6-(TRIFLUOROMETHYL)-;6-Trifluoromethyl-4(1H)-pyrimidinone;6-TRIFLUOROMETHYL-4-PYRIMIDINOL 98+%;4-HYDROXY-6-TRIFLUOROMETHYLPYRIMIDINE;6-trifluoromethyl-4-hydroxypyrimidine;4-Hydroxy-6-(trifluormethyl)-pyrimidin;6-(trifluoromethyl)pyrimidin-4(3H)-one;6-(trifluoromethyl)-1H-pyrimidin-4-one
CBNumber
CB5488081
Molecular Formula
C5H3F3N2O
Formula Weight
164.09
MOL File
1546-78-7.mol
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4-Hydroxy-6-(trifluoromethyl)pyrimidine Property

Melting point:
169-171 °C(lit.)
Boiling point:
130.3±50.0 °C(Predicted)
Density 
1.55±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
6.41±0.40(Predicted)
form 
Crystalline
color 
White
Water Solubility 
Solubility in methanol (almost transparency). Slightly soluble in water.
BRN 
145548
CAS DataBase Reference
1546-78-7(CAS DataBase Reference)
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HazardClass 
IRRITANT
HS Code 
29335990
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
385344
Product name
4-Hydroxy-6-(trifluoromethyl)pyrimidine
Purity
99%
Packaging
1g
Price
$43.3
Updated
2023/01/07
TCI Chemical
Product number
T1601
Product name
6-Trifluoromethyl-4-pyrimidinol
Purity
>98.0%(GC)(T)
Packaging
5g
Price
$36
Updated
2024/03/01
TCI Chemical
Product number
T1601
Product name
6-Trifluoromethyl-4-pyrimidinol
Purity
>98.0%(GC)(T)
Packaging
25g
Price
$129
Updated
2024/03/01
Alfa Aesar
Product number
H64381
Product name
4-Hydroxy-6-(trifluoromethyl)pyrimidine, 97%
Packaging
1g
Price
$31.4
Updated
2023/06/20
Alfa Aesar
Product number
H64381
Product name
4-Hydroxy-6-(trifluoromethyl)pyrimidine, 97%
Packaging
5g
Price
$141
Updated
2023/06/20
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4-Hydroxy-6-(trifluoromethyl)pyrimidine Chemical Properties,Usage,Production

Chemical Properties

White powder

Uses

4-Hydroxy-6-(trifluoromethyl)pyrimidine (6-(Trifluoromethyl)-4-pyrimidinol) may be used in the synthesis of 10-[3-(6-trifluoromethyl-pyrimidin-4-yloxy)-propoxy]-(20S)-camptothecin.

Uses

4-Hydroxy-6-(trifluoromethyl)pyrimidine is used as building block in chemical synthesis. Attributes Development Product Contact

Synthesis Reference(s)

Journal of the American Chemical Society, 80, p. 5744, 1958 DOI: 10.1021/ja01554a041

General Description

4-Hydroxy-6-(trifluoromethyl)pyrimidine, a pyrimidine derivative, is a heterocyclic building block.

4-Hydroxy-6-(trifluoromethyl)pyrimidine Preparation Products And Raw materials

Raw materials

Ethyl 4,4,4-trifluoroacetoacetate Hexane Ethanol Formamidine acetate Sodium sulfate Sodium FORMAMIDINE HYDROCHLORIDE Ethyl acetate Hydrochloric acid Methanol

Preparation Products

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4-Hydroxy-6-(trifluoromethyl)pyrimidine Suppliers

China 149 France 1 Germany 2 India 4 Japan 1 Switzerland 3 United Kingdom 1 United States 16 Global 177
Service Chemical Inc.
Tel
--
Fax
--
Email
sales@chemos-group.com
Country
Germany
ProdList
6350
Advantage
71
ABCR GmbH & CO. KG
Tel
--
Fax
--
Email
info@abcr.de
Country
Germany
ProdList
6831
Advantage
75
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View Lastest Price from 4-Hydroxy-6-(trifluoromethyl)pyrimidine manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
4-Hydroxy-6-(trifluoromethyl)pyrimidine 1546-78-7
Price
US $1.00-900.00/KG
Min. Order
1g
Purity
98%
Supply Ability
50ton
Release date
2020-05-15
Henan Aochuang Chemical Co.,Ltd.
Product
4-Hydroxy-6-(trifluoromethyl)pyrimidine 1546-78-7
Price
US $0.00-0.00/kg
Min. Order
1kg
Purity
98%
Supply Ability
1Ton
Release date
2022-09-28
Dideu Industries Group Limited
Product
4-Hydroxy-6-(trifluoromethyl)pyrimidine 1546-78-7
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-12-06

1546-78-7, 4-Hydroxy-6-(trifluoromethyl)pyrimidineRelated Search:

CHLOROPHOSPHONAZO III Benzotrifluoride Lithium trifluoromethanesulfonate 4-Aminobenzotrifluoride 4-Ethyl-5-fluoro-6-hydroxypyrimidine 4-Hydroxypyrimidine 2-ISOPROPYL-6-METHYL-4-PYRIMIDINOL (Trifluoromethyl)trimethylsilane 4,6-Dihydroxypyrimidine Pirimiphos-methyl Trifluoromethanesulfonic acid Trifluridine 4-HYDROXY-2-(METHYLTHIO)-6-(TRIFLUOROMETHYL)PYRIMIDINE 4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE-2-THIOL 2-Hydroxy-4-(trifluoromethyl)pyrimidine ETHYL 4-HYDROXY-2-(TRIFLUOROMETHYL)PYRIMIDINE-5-CARBOXYLATE 4-Hydroxy-2-(trifluoromethyl)pyrimidine 2-AMINO-4-HYDROXY-6-(TRIFLUOROMETHYL)PYRIMIDINE

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  • 6-(TRIFLUOROMETHYL)PYRIMIDIN-4-OL
  • 4-HYDROXY-6-TRIFLUOROMETHYLPYRIMIDINE
  • 4-PYRIMIDINOL, 6-(TRIFLUOROMETHYL)-
  • 4-Hydroxy-6-(trifluormethyl)-pyrimidin
  • 6-TRIFLUOROMETHYL-4-PYRIMIDINOL 98+%
  • 6-Trifluoromethyl-4(1H)-pyrimidinone
  • 4-Hydroxy-6-(trifluoromethyl)pyrimidine ,98%
  • 4(3H)-PyriMidinone, 6-(trifluoroMethyl)-
  • 4-Hydroxy-6-(trifluoromethyl)pyrimidine 6-(Trifluoromethyl)pyrimidin-4-ol
  • 4-Hydroxy-6-(trifluoromethyl)pyrimidine 99%
  • 6-(trifluoromethyl)pyrimidin-4(3H)-one
  • 6-trifluoromethyl-4-hydroxypyrimidine
  • 6-(trifluoromethyl)-1H-pyrimidin-4-one
  • 4-Hydroxy-6-(trifluoromethyl)pyrimidine ISO 9001：2015 REACH
  • 6-(Trifluoromethyl)-4(3H)-pyrimidinone
  • 1546-78-7
  • Heterocyclic Building Blocks
  • Pyrimidines
  • Building Blocks
  • Boronic Acid
  • Heterocyclic Compounds
  • Fluorinated pyrimidine derivatives
  • Pyrimidines
  • Pyrimidine series
  • alcohol
  • Fluorine series