ChemicalBook > CAS DataBase List > (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT

Product Name
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
CAS No.
60-99-1
Chemical Name
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
Synonyms
XP 03;rp7044;C07192;Nirvan;skf5116;Sinogan;cl36467;cl39743;cl53212;dedoran
CBNumber
CB5488571
Molecular Formula
C19H24N2OS
Formula Weight
328.47
MOL File
60-99-1.mol
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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Property

Melting point:
117°C
Boiling point:
468.0±45.0 °C(Predicted)
Density 
1.0897 (rough estimate)
refractive index 
1.5950 (estimate)
storage temp. 
Store at -20°C
solubility 
Chloroform (Slightly), Methanol (Very Slightly)
form 
Solid
pka
9.32±0.28(Predicted)
color 
White to Off-White
Water Solubility 
20mg/L(25 ºC)
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Safety

Hazard Codes 
Xn
Risk Statements 
20/21/22
Safety Statements 
36
RIDADR 
3249
RTECS 
SO6125000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2934302300
Toxicity
LD50 oral in rat: 1100mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
1415006
Product name
Methotrimeprazine maleate salt
Packaging
200mg
Price
$276
Updated
2024/03/01
TRC
Product number
M260770
Product name
(R)-Methotrimeprazine
Packaging
10mg
Price
$1470
Updated
2021/12/16
ChemScene
Product number
CS-0013678
Product name
Levomepromazine
Purity
99.98%
Packaging
10mg
Price
$85
Updated
2021/12/16
ChemScene
Product number
CS-0013678
Product name
Levomepromazine
Purity
99.98%
Packaging
50mg
Price
$250
Updated
2021/12/16
ChemScene
Product number
CS-0013678
Product name
Levomepromazine
Purity
99.98%
Packaging
100mg
Price
$420
Updated
2021/12/16
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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Chemical Properties,Usage,Production

Originator

Levoprome ,Lederle,US,1966

Uses

(R)-Methotrimeprazine acts as an analgesic agent.

Definition

ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.

Manufacturing Process

95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.

brand name

Levoprome (Immunex).

Therapeutic Function

Analgesic

(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Suppliers

Canada 1 China 29 France 1 Germany 1 India 2 Italy 1 South Korea 1 Switzerland 2 United Kingdom 1 United States 14 Global 53
Sinopharm Chemical Reagent Co,Ltd.
Tel
86-21-63210123
Fax
86-21-63290778 86-21-63218885
Email
sj_scrc@sinopharm.com
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China
ProdList
9815
Advantage
79
BOC Sciences
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1-631-485-4226; 16314854226
Email
info@bocsci.com
Country
United States
ProdList
14055
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65
ShangHai Caerulum Pharma Discovery Co., Ltd.
Tel
18149758185 18149758185
Email
sales-cpd@caerulumpharma.com
Country
China
ProdList
3466
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58
Shanghai Kewel Chemical Co., Ltd.
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021-64609169 18901607656
Fax
021-64609160
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greensnown@163.com
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China
ProdList
9906
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Chizhou Kailong Import and Export Trade Co., Ltd.
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Fax
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xg01_gj@163.com
Country
China
ProdList
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BOC Sciences
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16314854226
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info@bocsci.com
Country
United States
ProdList
9923
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Beijing Solarbio Science & Tecnology Co., Ltd.
Tel
010-50973186 4009686088
Email
3193328036@qq.com
Country
China
ProdList
18338
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TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32063
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58
Dayang Chem (Hangzhou) Co.,Ltd.
Tel
571-88938639 +8617705817739
Fax
+86-571-88938652，+86-571- 88492614
Email
info@dycnchem.com
Country
China
ProdList
52849
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58
AFINE CHEMICALS LIMITED
Tel
+86-0571-85134551
Fax
008657185134895
Email
sales@afinechem.com
Country
China
ProdList
15357
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View Lastest Price from (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT manufacturers

Xiamen Wonderful Bio Technology Co., Ltd.
Product
Levomepromazine 60-99-1
Price
US $66.00/kg
Min. Order
1kg
Purity
99.98%
Supply Ability
1
Release date
2023-06-08

60-99-1, (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALTRelated Search:

2-Methoxyphenothiazine Phenothiazine (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Methotrimeprazine Sulfoxide

  • methotrimeprazine maleate
  • rp7044
  • Sinogan
  • Sinogan-Debil
  • SK&F 5116
  • SKF 5116
  • skf5116
  • Tisercin
  • Veractil
  • (bR)-2-Methoxy-N,N,b-trimethyl-10H-phenothiazine-10-propanamine
  • Levoprom
  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,.beta.-trimethyl-, (.beta.R)-
  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, (bR)- (9CI)
  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,b-trimethyl-, (R)-
  • NSC 226516
  • Phenothiazine, 10-[3-(dimethylamino)-2-methylpropyl]-2-methoxy-, (-)- (8CI)
  • XP 03
  • (R)-2-Methoxy-N,N,-trimethyl-10H-phenothiazine-10-propanamine
  • C07192
  • Methotrimeprazine-d3 maleate
  • Methotrimeprazine (200 mg)
  • 10H-Phenothiazine-10-propanaMine, 2-Methoxy-N,N,β-triMethyl-, (βR)-
  • (2R)-3-(2-methoxyphenothiazin-10-yl)-N,N,2-trimethylpropan-1-amine
  • (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
  • METHOTRIMEPRAZINE MALEATE SALT
  • (-)-10-(3-(Dimethylamino)-2-methylpropyl)-2-methoxyphenothiazine
  • (-)-3-(2-Methoxyphenothiazin-10-yl)-2-methylpropyldimethylamine
  • (-)-phenothiazin
  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (-)-
  • 10H-Phenothiazine-10-propanamine, 2-methoxy-N,N,beta-trimethyl-, (R)-
  • 2-Methoxytrimeprazine
  • 3-(2-Methoxy-10H-phenothiazin-10-yl)-N,N,2-trimethyl-1-propanamine
  • 7044 R.P.
  • arc-vi-c-5
  • bayer1213
  • CL 36467
  • CL 39743
  • cl36467
  • cl39743
  • cl53212
  • dedoran
  • Hirnamin
  • hirnamine
  • Levomeprazine
  • Levomepromazin
  • Levomepromazine
  • Levomepropazine
  • Levopromazine
  • levopromazioni
  • Levoprome
  • Levopromethazine
  • Levotomin
  • Mepromazine
  • methotrimeprazine
  • methoxytrimeprazine
  • milezin
  • minozinan
  • n,beta-trimethyl-2-methoxy-(r)-10h-phenothiazine-10-propanamin