ChemicalBook > CAS DataBase List > (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
- Product Name
- (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
- CAS No.
- 60-99-1
- Chemical Name
- (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
- Synonyms
- XP 03;rp7044;C07192;Nirvan;skf5116;Sinogan;cl36467;cl39743;cl53212;dedoran
- CBNumber
- CB5488571
- Molecular Formula
- C19H24N2OS
- Formula Weight
- 328.47
- MOL File
- 60-99-1.mol
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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Property
- Melting point:
- 117°C
- Boiling point:
- 468.0±45.0 °C(Predicted)
- Density
- 1.0897 (rough estimate)
- refractive index
- 1.5950 (estimate)
- storage temp.
- Store at -20°C
- solubility
- Chloroform (Slightly), Methanol (Very Slightly)
- form
- Solid
- pka
- 9.32±0.28(Predicted)
- color
- White to Off-White
- Water Solubility
- 20mg/L(25 ºC)
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- 1415006
- Product name
- Methotrimeprazine maleate salt
- Packaging
- 200mg
- Price
- $464
- Updated
- 2025/07/31
TRC
- Product number
- M260770
- Product name
- (R)-Methotrimeprazine
- Packaging
- 10mg
- Price
- $1470
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0013678
- Product name
- Levomepromazine
- Purity
- 99.98%
- Packaging
- 10mg
- Price
- $85
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0013678
- Product name
- Levomepromazine
- Purity
- 99.98%
- Packaging
- 50mg
- Price
- $250
- Updated
- 2021/12/16
ChemScene
- Product number
- CS-0013678
- Product name
- Levomepromazine
- Purity
- 99.98%
- Packaging
- 100mg
- Price
- $420
- Updated
- 2021/12/16
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(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Chemical Properties,Usage,Production
Originator
Levoprome ,Lederle,US,1966
Uses
(R)-Methotrimeprazine acts as an analgesic agent.
Definition
ChEBI: A member of the class of phenothiazines that is 10H-phenothiazine substituted by a (2R)-3-(dimethylamino)-2-methylpropyl group and a methoxy group at positions 10 and 2 respectively.
Manufacturing Process
95% sodamide (2.33 g) is added to a boiling solution of 3- methoxyphenthiazine (12 g) in anhydrous xylene (150 cc) and the mixture is heated with agitation under reflux for 1? hours. A solution of 1- dimethylamino-2-methyl-3-chloropropane (8.2 g) in anhydrous xylene (90 cc) is then run in over a period of 45 minutes while the reaction temperature is maintained and heating under reflux is continued for 18 hours.
After cooling, the reaction mixture is agitated with a mixture of water (40 cc) and a normal solution of methanesulfonic acid (70 cc), the xylene layer is removed and the acid liquors are washed with ether (200 cc). The aqueous phase is then made alkaline with sodium hydroxide (d = 1.33; 10 cc) and the liberated base is extracted with ether. The ethereal solution is dried over anhydrous potassium carbonate and concentrated at normal pressure. On distillation of the residue under reduced pressure 3-(3-methoxy-10- phenthiazinyl)-2-methyl-1-dimethylaminopropane (11.3 g) is obtained, MP 103°C, BP 182° to 191°C/0.15 mm Hg. The hydrochloride prepared in isopropanol melts at about 90°C.
brand name
Levoprome (Immunex).
Therapeutic Function
Analgesic
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT manufacturers
Xiamen Wonderful Bio Technology Co., Ltd.
- Product
- Levomepromazine 60-99-1
- Price
- US $66.00/kg
- Min. Order
- 1kg
- Purity
- 99.98%
- Supply Ability
- 1
- Release date
- 2023-06-08
60-99-1, (-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALTRelated Search:
2-Methoxyphenothiazine
Phenothiazine
(-)-10-(3-[DIMETHYLAMINO]-2-METHYLPROPYL)-2-METHOXY-PHENOTHIAZINE MALEATE SALT
Methotrimeprazine Sulfoxide