Nicotinoyl chloride hydrochloride
- Product Name
- Nicotinoyl chloride hydrochloride
- CAS No.
- 20260-53-1
- Chemical Name
- Nicotinoyl chloride hydrochloride
- Synonyms
- (R)-1-(pyridin-2-yl)ethanaMine hydrochloride;NicotinoyL;NICOTINYL CHLORIDE HYDROCHLORIDE;NicotinoylchlorideHcl;Piraxostat Impurity 42;SMokechloridehydrochloride;3-PYRIDINECARBONYL CHLORIDE;Nicotinoyl chloride hcl,98%;3-Pyridinecarbonyl chloride HCl;Pyridine-3-Carbonyl Chloride Hcl
- CBNumber
- CB5488687
- Molecular Formula
- C6H5Cl2NO
- Formula Weight
- 178.02
- MOL File
- 20260-53-1.mol
Nicotinoyl chloride hydrochloride Property
- Melting point:
- 151-157 °C(lit.)
- storage temp.
- under inert gas (nitrogen or Argon) at 2-8°C
- form
- Crystalline Powder
- color
- White to off-white
- Water Solubility
- It decomposes in water.
- Sensitive
- Moisture Sensitive
- BRN
- 3655772
- InChI
- InChI=1S/C6H4ClNO.ClH/c7-6(9)5-2-1-3-8-4-5;/h1-4H;1H
- InChIKey
- MSYBLBLAMDYKKZ-UHFFFAOYSA-N
- SMILES
- C(Cl)(=O)C1=CN=CC=C1.[H]Cl
- CAS DataBase Reference
- 20260-53-1(CAS DataBase Reference)
- EPA Substance Registry System
- 3-Pyridinecarbonyl chloride, hydrochloride (20260-53-1)
Safety
- Hazard Codes
- C
- Risk Statements
- 34
- Safety Statements
- 26-28-36/37/39-45
- RIDADR
- UN 3261 8/PG 2
- WGK Germany
- 3
- TSCA
- Yes
- HazardClass
- 8
- PackingGroup
- III
- HS Code
- 29333990
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P260Do not breathe dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P363Wash contaminated clothing before reuse.
N-Bromosuccinimide Price
- Product number
- 213381
- Product name
- Nicotinoyl chloride hydrochloride
- Purity
- 97%
- Packaging
- 25g
- Price
- $71.8
- Updated
- 2024/03/01
- Product number
- N0091
- Product name
- Nicotinoyl Chloride Hydrochloride
- Purity
- >95.0%(T)
- Packaging
- 25g
- Price
- $45
- Updated
- 2025/07/31
- Product number
- N0091
- Product name
- Nicotinoyl Chloride Hydrochloride
- Purity
- >95.0%(T)
- Packaging
- 100g
- Price
- $134
- Updated
- 2025/07/31
- Product number
- N0091
- Product name
- Nicotinoyl Chloride Hydrochloride
- Purity
- >95.0%(T)
- Packaging
- 500g
- Price
- $657
- Updated
- 2025/07/31
- Product number
- N431250
- Product name
- Nicotinoyl chloride hydrochloride
- Packaging
- 25g
- Price
- $60
- Updated
- 2021/12/16
Nicotinoyl chloride hydrochloride Chemical Properties,Usage,Production
Chemical Properties
white to off-white crystalline powder
Uses
Nicotinoyl chloride hydrochloride was used in the preparation of 1-[5-O-tert-butyldimethylsilyl-2-deoxy-2-fluoro-3-O-(3-pyridylcarbonyl)-β-D-ribofuranosyl]uracil, bis(ethylenedithio)tetrathiafulvalene derivatives and 7,16-dinicotinoylated or 7,16-diisonicotinoylated compounds via reaction with tetraaza[14]annulene and its complexes.
Uses
Nicotinoyl chloride hydrochloride was used in the preparation of :
- 1-[5-O-tert-butyldimethylsilyl-2-deoxy-2-fluoro-3-O-(3-pyridylcarbonyl)-β-D-ribofuranosyl]uracil
- 7,16-dinicotinoylated and/or 7,16-diisonicotinoylated compounds via reaction with tetraaza[14]annulene and its complexes
- bis(ethylenedithio)tetrathiafulvalene derivatives
Uses
As a Nicotinic Acid analog, Nicotinoyl chloride hydrochloride can be used in the preparation of cardiovascular agents and renal drugs.
Synthesis
59-67-6
20260-53-1
Niacin (8.12 mmol) and 2 drops of anhydrous DMF were added to SOCl2 (10 mL) under anhydrous conditions with vigorous stirring at 0°C. The reaction mixture was heated to 78 °C and refluxed for 3 hours. Upon completion of the reaction, the excess SOCl2 was removed by evaporation under reduced pressure to give a yellow solid. Subsequently, 10 mL of diethyl ether was added to the solid and refluxed for 1 hour. The reaction mixture was filtered to give a white solid nicotinoyl chloride hydrochloride in a yield of 1.388 g (yield: 96.0%).
References
[1] Dalton Transactions, 2005, # 3, p. 424 - 426
[2] Journal of Organic Chemistry, 2009, vol. 74, # 17, p. 6691 - 6702
[3] Green Chemistry, 2009, vol. 11, # 1, p. 83 - 90
[4] Molecules, 2014, vol. 19, # 4, p. 4791 - 4801
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2011, vol. 186, # 3, p. 552 - 557
Nicotinoyl chloride hydrochloride Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from Nicotinoyl chloride hydrochloride manufacturers
- Product
- NICOTINOYL CHLORIDE HYDROCHLORIDE 20260-53-1
- Price
- US $8.00/kg
- Min. Order
- 1kg
- Purity
- 99%
- Supply Ability
- 10MT
- Release date
- 2018-12-21