ChemicalBook > CAS DataBase List > Nicotinoyl chloride hydrochloride

Nicotinoyl chloride hydrochloride

Product Name: Nicotinoyl chloride hydrochloride
CAS No.: 20260-53-1
Chemical Name: Nicotinoyl chloride hydrochloride
Synonyms: (R)-1-(pyridin-2-yl)ethanaMine hydrochloride;NicotinoyL;NICOTINYL CHLORIDE HYDROCHLORIDE;NicotinoylchlorideHcl;Piraxostat Impurity 42;SMokechloridehydrochloride;3-PYRIDINECARBONYL CHLORIDE;Nicotinoyl chloride hcl,98%;3-Pyridinecarbonyl chloride HCl;Pyridine-3-Carbonyl Chloride Hcl
CBNumber: CB5488687
Molecular Formula: C6H5Cl2NO
Formula Weight: 178.02
MOL File: 20260-53-1.mol

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Nicotinoyl chloride hydrochloride Property

Melting point:: 151-157 °C(lit.)
storage temp.: under inert gas (nitrogen or Argon) at 2-8°C
form: Crystalline Powder
color: White to off-white
Water Solubility: It decomposes in water.
Sensitive: Moisture Sensitive
BRN: 3655772
InChI: InChI=1S/C6H4ClNO.ClH/c7-6(9)5-2-1-3-8-4-5;/h1-4H;1H
InChIKey: MSYBLBLAMDYKKZ-UHFFFAOYSA-N
SMILES: C(Cl)(=O)C1=CN=CC=C1.[H]Cl
CAS DataBase Reference: 20260-53-1(CAS DataBase Reference)
EPA Substance Registry System: 3-Pyridinecarbonyl chloride, hydrochloride (20260-53-1)

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Safety

Hazard Codes: C
Risk Statements: 34
Safety Statements: 26-28-36/37/39-45
RIDADR: UN 3261 8/PG 2
WGK Germany: 3
TSCA: Yes
HazardClass: 8
PackingGroup: III
HS Code: 29333990

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H314Causes severe skin burns and eye damage

Precautionary statements

P260Do not breathe dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P363Wash contaminated clothing before reuse.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 213381
Product name: Nicotinoyl chloride hydrochloride
Purity: 97%
Packaging: 25g
Price: $71.8
Updated: 2024/03/01

TCI Chemical

Product number: N0091
Product name: Nicotinoyl Chloride Hydrochloride
Purity: >95.0%(T)
Packaging: 25g
Price: $45
Updated: 2025/07/31

TCI Chemical

Product number: N0091
Product name: Nicotinoyl Chloride Hydrochloride
Purity: >95.0%(T)
Packaging: 100g
Price: $134
Updated: 2025/07/31

TCI Chemical

Product number: N0091
Product name: Nicotinoyl Chloride Hydrochloride
Purity: >95.0%(T)
Packaging: 500g
Price: $657
Updated: 2025/07/31

TRC

Product number: N431250
Product name: Nicotinoyl chloride hydrochloride
Packaging: 25g
Price: $60
Updated: 2021/12/16

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Nicotinoyl chloride hydrochloride Chemical Properties,Usage,Production

Chemical Properties

white to off-white crystalline powder

Uses

Nicotinoyl chloride hydrochloride was used in the preparation of 1-[5-O-tert-butyldimethylsilyl-2-deoxy-2-fluoro-3-O-(3-pyridylcarbonyl)-β-D-ribofuranosyl]uracil, bis(ethylenedithio)tetrathiafulvalene derivatives and 7,16-dinicotinoylated or 7,16-diisonicotinoylated compounds via reaction with tetraaza[14]annulene and its complexes.

Uses

Nicotinoyl chloride hydrochloride was used in the preparation of :

1-[5-O-tert-butyldimethylsilyl-2-deoxy-2-fluoro-3-O-(3-pyridylcarbonyl)-β-D-ribofuranosyl]uracil
7,16-dinicotinoylated and/or 7,16-diisonicotinoylated compounds via reaction with tetraaza[14]annulene and its complexes
bis(ethylenedithio)tetrathiafulvalene derivatives

Uses

As a Nicotinic Acid analog, Nicotinoyl chloride hydrochloride can be used in the preparation of cardiovascular agents and renal drugs.

Synthesis

59-67-6

20260-53-1

Niacin (8.12 mmol) and 2 drops of anhydrous DMF were added to SOCl2 (10 mL) under anhydrous conditions with vigorous stirring at 0°C. The reaction mixture was heated to 78 °C and refluxed for 3 hours. Upon completion of the reaction, the excess SOCl2 was removed by evaporation under reduced pressure to give a yellow solid. Subsequently, 10 mL of diethyl ether was added to the solid and refluxed for 1 hour. The reaction mixture was filtered to give a white solid nicotinoyl chloride hydrochloride in a yield of 1.388 g (yield: 96.0%).

References

[1] Dalton Transactions, 2005, # 3, p. 424 - 426
[2] Journal of Organic Chemistry, 2009, vol. 74, # 17, p. 6691 - 6702
[3] Green Chemistry, 2009, vol. 11, # 1, p. 83 - 90
[4] Molecules, 2014, vol. 19, # 4, p. 4791 - 4801
[5] Phosphorus, Sulfur and Silicon and the Related Elements, 2011, vol. 186, # 3, p. 552 - 557

Nicotinoyl chloride hydrochloride Preparation Products And Raw materials

Raw materials

Preparation Products

Nicorandil

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View Lastest Price from Nicotinoyl chloride hydrochloride manufacturers

Career Henan Chemical Co

Product: NICOTINOYL CHLORIDE HYDROCHLORIDE 20260-53-1
Price: US $8.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 10MT
Release date: 2018-12-21

20260-53-1, Nicotinoyl chloride hydrochlorideRelated Search:

ETHYL 4-PYRIDYLACETATE 2-PHENOXYBENZOYL CHLORIDE 2-(METHYLTHIO)NICOTINYL CHLORIDE 5-BROMONICOTINOYL CHLORIDE METHYL ISONICOTINATE 2-(PROPYLTHIO)PYRIDINE-3-CARBONYL CHLORIDE 2-(ETHYLTHIO)NICOTINOYL CHLORIDE 4-CHLORO-1,3-DIMETHYLPYRAZOLO[3,4-B]PYRIDINE-5-CARBONYL CHLORIDE 6-(TRIFLUOROMETHYL)NICOTINOYL CHLORIDE Nicotinoyl chloride hydrochloride 2-Chloronicotinyl chloride 2,6-DICHLORO-5-FLUORONICOTINOYL CHLORIDE 4-Pyridineacetic acid hydrochloride 2-[(4-METHYLPHENYL)THIO]PYRIDINE-3-CARBONYL CHLORIDE 2-[(4-CHLOROPHENYL)THIO]PYRIDINE-3-CARBONYL CHLORIDE 2-(PHENYLTHIO)PYRIDINE-3-CARBONYL CHLORIDE 6-CHLORONICOTINOYL CHLORIDE NICOTINYL CHLORIDE HYDROCHLORIDE

3-pyridinecarbonylchloride,hydrochloride

3-PYRIDINECARBONYL CHLORIDE

3-PYRIDINOYL CHLORIDE HYDROCHLORIDE

3-PYRIDINECARBOXYLIC ACID CHLORIDE HYDROCHLORIDE

NICOTINIC ACID CHLORIDE HYDROCHLORIDE

NICOTINOYL CHLORIDE HYDROCHLORIDE

NICOTINYL CHLORIDE HYDROCHLORIDE

PYRIDINE-3-CARBONYL CHLORIDE HYDROCHLORIDE

NicotinoylchlorideHcl

Nicotinoyl chloride hydrochloride,97%

Nicotinoyl chloride hydrochloride, 97% 25GR

Nicotinoyl chloride hydrochloride, 97% 5GR

Pyridine-3-Carbonyl Chloride Hcl

3-(chlorocarbonyl)pyridin-1-iuM chloride

(R)-1-(pyridin-2-yl)ethanaMine hydrochloride

Nicotinoyl chloride hydrochloride 97%

SMokechloridehydrochloride

(pyridin-3-yl)carbonylchloranuide hydrochloride

PI-18307 3-Pyridinecarbonyl chloride

3-Pyridinecarbonylchloride, hydrochloride (1:1)

NicotinoylChlorideHydrochloride&gt

NicotinoyL

Nicotinoyl chloride hcl,98%

Piraxostat Impurity 42

3-Pyridinecarbonyl chloride HCl

20260-53-1

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