1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

Product Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
CAS No.: 1357349-91-7
Chemical Name: 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine
Synonyms: SPP 86;SPP86 >=98% (HPLC);SPP-86, 10 mM in DMSO;Inhibitor,inhibit,SPP-86,SPP 86,SPP86,RET;1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine;1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-
CBNumber: CB54902611
Molecular Formula: C16H15N5
Formula Weight: 277.32
MOL File: 1357349-91-7.mol

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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Property

Boiling point:: 495.3±40.0 °C(Predicted)
Density: 1.23±0.1 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble in DMSO
pka: 3.95±0.30(Predicted)
form: Solid
color: Off-white to light yellow
InChI: 1S/C16H15N5/c1-11(2)21-16-14(15(17)18-10-19-16)13(20-21)9-8-12-6-4-3-5-7-12/h3-7,10-11H,1-2H3,(H2,17,18,19)
InChIKey: JQOIRTDBHMDWMT-UHFFFAOYSA-N
SMILES: NC1=NC=NC2=C1C(C#CC3=CC=CC=C3)=NN2C(C)C

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids
Hazard Classifications: Acute Tox. 4 Oral

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Cayman Chemical

Product number: 37390
Product name: SPP 86
Purity: ≥98%
Packaging: 1mg
Price: $28
Updated: 2026/04/30

Cayman Chemical

Product number: 37390
Product name: SPP 86
Purity: ≥98%
Packaging: 5mg
Price: $125
Updated: 2026/04/30

Cayman Chemical

Product number: 37390
Product name: SPP 86
Purity: ≥98%
Packaging: 10mg
Price: $207
Updated: 2026/04/30

Cayman Chemical

Product number: 37390
Product name: SPP 86
Purity: ≥98%
Packaging: 25mg
Price: $413
Updated: 2026/04/30

Tocris

Product number: 5391
Product name: SPP86
Purity: ≥98%(HPLC)
Packaging: 10
Price: $219
Updated: 2021/12/16

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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Chemical Properties,Usage,Production

Uses

SPP 86 is a potent RET Kinase inhibitor.

Biological Activity

SPP86 is a potent cell permeable inihbitor of RET tyrosine kinase with an IC50 value of 8 nM and with some inhibitory activity at EphA1, FGFR1, Flt4, Lck and Yes. SPP86 does not inhibit p38, CSK, KIT, PDGF, Src or BCR-ABL. SPP86 inhibited RET-mediated activation of the PI3K/Akt and MAPK pathways at doses of 0.1- 1 μM in a cell line expressing oncogenic RET and inhibited RET-induced ERα phosphorylation and proliferation in MCF7 cells with an IC50 value of 1.0 μM, similar to tamoxifen.

storage

Store at +4°C

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Preparation Products And Raw materials

Raw materials

Preparation Products

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1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine Suppliers

China 37 United Kingdom 1 United States 4 USA 1 Global 43

Shanghai YuanYe Biotechnology Co., Ltd.

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ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
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TargetMol Chemicals Inc.

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Energy Chemical

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Jinan Jiuli Biotechnology Co. , Ltd.

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Bide Pharmatech Ltd.

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1357349-91-7, 1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amineRelated Search:

1-(1-Methylethyl)-3-(2-phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SPP 86

1H-Pyrazolo[3,4-d]pyrimidin-4-amine, 1-(1-methylethyl)-3-(2-phenylethynyl)-

SPP86 >=98% (HPLC)

Inhibitor,inhibit,SPP-86,SPP 86,SPP86,RET

1-Isopropyl-3-(phenylethynyl)-1H-pyrazolo[3,4-d]pyrimidin-4-amine

SPP-86, 10 mM in DMSO

1357349-91-7