ChemicalBook > CAS DataBase List > 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide

Product Name
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
CAS No.
1776116-74-5
Chemical Name
5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
Synonyms
MC 1742;MC1742,MC-1742;5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide;Pentanamide, 5-[(4-[1,1'-biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxy-
CBNumber
CB54902828
Molecular Formula
C21H21N3O3S
Formula Weight
395.47
MOL File
1776116-74-5.mol
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5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Property

Density 
1.29±0.1 g/cm3(Predicted)
storage temp. 
Store at -20°C
solubility 
DMSO: 100 mM
form 
A solid
pka
7.51±0.50(Predicted)
color 
White to off-white
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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

Cayman Chemical
Product number
29171
Product name
MC1742
Packaging
5mg
Price
$533
Updated
2024/03/01
Cayman Chemical
Product number
29171
Product name
MC1742
Packaging
10mg
Price
$911
Updated
2024/03/01
Cayman Chemical
Product number
29171
Product name
MC1742
Packaging
1mg
Price
$153
Updated
2024/03/01
TRC
Product number
M479003
Product name
MC1742
Packaging
1mg
Price
$165
Updated
2021/12/16
AK Scientific
Product number
7289EM
Product name
N-Hydroxy-5-[[6-oxo-4-(4-phenylphenyl)-1H-pyrimidin-2-yl]sulfanyl]pentanamide
Packaging
1mg
Price
$268
Updated
2021/12/16
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5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Chemical Properties,Usage,Production

Uses

MC 1742 is a novel histone deacetylase inhibitor, which has been shown to induce growth arrest, apoptosis and differentiation in sarcoma cancer stem cells.

Biological Activity

MC1742 is a uracil-based hydroxyamide (UBHA) th at acts as a subtype-selective histone deacetylases (HDACs) inhibitor (IC50: class I HDAC1/2/3/8 = 100/110/20/610 nM, class IIB HDAC6/10 = 7/40 nM, class IV HDAC11 = 100 nM, class IIA HDAC4/5/7/9 >50 μM). MC1742 exerts greater antiproliferation potency than SAHA in sarcoma cancer stem cell (CSC) cultures (MC1742/SAHA IC50 in μM = 0.25/1/RD, 1.12/1.13//MG-63, 1.4/3.92/SK-ES-1 post 72-hr treatment) and effectively reactivates HIV from latency (EC50 = 350 nM; JL at 10.6 cells) by upregulating histone acetylation at the HIV promoter without activating T cells.

storage

Store at -20°C

5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Preparation Products And Raw materials

Raw materials

Preparation Products

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5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide Suppliers

China 13 United Kingdom 1 United States 4 USA 1 Global 19
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38631
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Aladdin Scientific
Tel
Email
tp@aladdinsci.com
Country
United States
ProdList
52924
Advantage
58
Cayman Chemical Company
Tel
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Fax
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
Advantage
81
United States Biological
Tel
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Fax
--
Email
chemicals@usbio.net
Country
United States
ProdList
6214
Advantage
80

1776116-74-5, 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamideRelated Search:


  • 5-[(4-[1,1'-Biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxypentanamide
  • MC 1742
  • Pentanamide, 5-[(4-[1,1'-biphenyl]-4-yl-1,6-dihydro-6-oxo-2-pyrimidinyl)thio]-N-hydroxy-
  • MC1742,MC-1742
  • 1776116-74-5