ALCLOFENAC
- Product Name
- ALCLOFENAC
- CAS No.
- 22131-79-9
- Chemical Name
- ALCLOFENAC
- Synonyms
- Argun;w7320;Epinal;Mervan;W 7320;MY 101;Neosten;Neoston;Zumaril;Reufenac
- CBNumber
- CB5491171
- Molecular Formula
- C11H11ClO3
- Formula Weight
- 226.66
- MOL File
- 22131-79-9.mol
ALCLOFENAC Property
- Melting point:
- 90-91°C
- Boiling point:
- 324.6°C (rough estimate)
- Density
- 1.2401 (rough estimate)
- refractive index
- 1.4530 (estimate)
- storage temp.
- Refrigerator
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- pKa 10.3 (Uncertain)
- form
- Solid
- color
- Off-White to Pale Yellow
- Water Solubility
- 13.1mg/L(25 ºC)
Safety
- Toxicity
- LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P330Rinse mouth.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- T100277
- Product name
- (4-(ALLYLOXY)-3-CHLOROPHENYL)ACETIC ACID
- Purity
- Aldrich
- Packaging
- 50mg
- Price
- $179
- Updated
- 2024/03/01
- Product number
- A514550
- Product name
- Alclofenac
- Packaging
- 50mg
- Price
- $130
- Updated
- 2021/12/16
- Product number
- 19416
- Product name
- Alclofenac
- Packaging
- 100mg
- Price
- $2620
- Updated
- 2021/12/16
- Product number
- FA17267
- Product name
- Alclofenac
- Packaging
- 250mg
- Price
- $360
- Updated
- 2021/12/16
- Product number
- FA17267
- Product name
- Alclofenac
- Packaging
- 500mg
- Price
- $425
- Updated
- 2021/12/16
ALCLOFENAC Chemical Properties,Usage,Production
Chemical Properties
Off-White to Pale Yellow Solid
Originator
Allopydin ,Chugai ,Japan ,1976
Uses
Analgesic; antipyretic; anti-inflammatory.
Definition
ChEBI: An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and r sh.
Manufacturing Process
103.7 grams of 3-chloro-4-allyloxyphenylacetonitrile in 500 cc of ethanol, 100 grams of potassium hydroxide and 100 cc of water are refluxed for 4 hours. Maximum of alcohol is evaporated, the residue is diluted with water and ice, and acidified with 20% HCl. The solid is filtered and washed with petroleum ether. 91.5 grams of acid are obtained (Yield: 81%) which is recrystallized from aqueous methanol; MP 92-93°C.
brand name
Mervan (Continental Pharma, Belgium);Allopydinac;Alopidin;Alopydin;Argan;Darkeyfenac;Desinflam;Medifenac;Mevan;Mirvan a;Prinalgin;Vanadian;W-7320;Zubirol.
Therapeutic Function
Antiinflammatory
World Health Organization (WHO)
Alclofenac, a phenylacetic acid derivative with analgesic, antipyretic and antiinflammatory activity, was introduced in 1972 for the treatment of rheumatic disorders. In the late 1970s its use was associated with a high incidence of adverse effects, mainly skin rashes, and a urinary metabolite was reported to have mutagenic activity (positive Ames test). This resulted in the withdrawal of the drug, in some cases voluntarily, from several countries. In others registration has been refused. The reported mutagenic potential has been questioned by some investigators and the drug remains on the market in at least three countries with highly evolved regulatory authorities.
Dosage
Alclofenac when used at 3 g/d in the treatment of rheumatoid arthritis is as effective as 75 mg/d of indomethacin with fewer adverse effects. In the treatment of osteoarthritis 1500 mg/d is as effective and is better tolerated than 300 mg/d of phenylbutazone. Alclofenac has been withdrawn from the market in the United Kingdom because of skin rash and vasculitis (blood vessel inflammation).
ALCLOFENAC Preparation Products And Raw materials
Raw materials
Preparation Products
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