ALCLOFENAC

Product Name: ALCLOFENAC
CAS No.: 22131-79-9
Chemical Name: ALCLOFENAC
Synonyms: Argun;w7320;Epinal;Mervan;W 7320;MY 101;Neosten;Neoston;Zumaril;Reufenac
CBNumber: CB5491171
Molecular Formula: C11H11ClO3
Formula Weight: 226.66
MOL File: 22131-79-9.mol

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ALCLOFENAC Property

Melting point:: 90-91°C
Boiling point:: 324.6°C (rough estimate)
Density: 1.2401 (rough estimate)
refractive index: 1.4530 (estimate)
storage temp.: Refrigerator
solubility: Chloroform (Slightly), Methanol (Slightly)
pka: pKa 10.3 (Uncertain)
form: Solid
color: Off-White to Pale Yellow
Water Solubility: 13.1mg/L(25 ºC)

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Safety

Toxicity: LD50 in mice, rats (mg/kg): 1100, 1050 orally; 600, 630 s.c.; 555, 530 i.p. (Lambelin)

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P330Rinse mouth.

P501Dispose of contents/container to..…

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T100277
Product name: (4-(ALLYLOXY)-3-CHLOROPHENYL)ACETIC ACID
Purity: Aldrich
Packaging: 50mg
Price: $179
Updated: 2024/03/01

TRC

Product number: A514550
Product name: Alclofenac
Packaging: 50mg
Price: $130
Updated: 2021/12/16

Medical Isotopes, Inc.

Product number: 19416
Product name: Alclofenac
Packaging: 100mg
Price: $2620
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17267
Product name: Alclofenac
Packaging: 250mg
Price: $360
Updated: 2021/12/16

Biosynth Carbosynth

Product number: FA17267
Product name: Alclofenac
Packaging: 500mg
Price: $425
Updated: 2021/12/16

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ALCLOFENAC Chemical Properties,Usage,Production

Chemical Properties

Off-White to Pale Yellow Solid

Originator

Allopydin ,Chugai ,Japan ,1976

Uses

Analgesic; antipyretic; anti-inflammatory.

Definition

ChEBI: An aromatic ether in which the ether oxygen links an allyl group to the 4-position of (3-chlorophenyl)acetic acid.A non-steroidal anti-inflammatory drug, it was withdrawn from the UK market in 1979 due to concerns with its association with vasculitis and r sh.

Manufacturing Process

103.7 grams of 3-chloro-4-allyloxyphenylacetonitrile in 500 cc of ethanol, 100 grams of potassium hydroxide and 100 cc of water are refluxed for 4 hours. Maximum of alcohol is evaporated, the residue is diluted with water and ice, and acidified with 20% HCl. The solid is filtered and washed with petroleum ether. 91.5 grams of acid are obtained (Yield: 81%) which is recrystallized from aqueous methanol; MP 92-93°C.

brand name

Mervan (Continental Pharma, Belgium);Allopydinac;Alopidin;Alopydin;Argan;Darkeyfenac;Desinflam;Medifenac;Mevan;Mirvan a;Prinalgin;Vanadian;W-7320;Zubirol.

Therapeutic Function

Antiinflammatory

World Health Organization (WHO)

Alclofenac, a phenylacetic acid derivative with analgesic, antipyretic and antiinflammatory activity, was introduced in 1972 for the treatment of rheumatic disorders. In the late 1970s its use was associated with a high incidence of adverse effects, mainly skin rashes, and a urinary metabolite was reported to have mutagenic activity (positive Ames test). This resulted in the withdrawal of the drug, in some cases voluntarily, from several countries. In others registration has been refused. The reported mutagenic potential has been questioned by some investigators and the drug remains on the market in at least three countries with highly evolved regulatory authorities.

Dosage

Alclofenac when used at 3 g/d in the treatment of rheumatoid arthritis is as effective as 75 mg/d of indomethacin with fewer adverse effects. In the treatment of osteoarthritis 1500 mg/d is as effective and is better tolerated than 300 mg/d of phenylbutazone. Alclofenac has been withdrawn from the market in the United Kingdom because of skin rash and vasculitis (blood vessel inflammation).

ALCLOFENAC Preparation Products And Raw materials

Raw materials

Benzeneacetonitrile Allyl phenyl ether

Preparation Products

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ALCLOFENAC Suppliers

Canada 1 China 29 Europe 1 Germany 1 India 3 United Kingdom 4 United States 13 Global 52

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22131-79-9, ALCLOFENACRelated Search:

alclofenac epoxide SALOR-INT L129054-1EA 3-CHLORO-4-HYDROXYPHENYLACETIC ACID 3-CHLORO-4-METHOXYTOLUENE 2-(4-ETHOXYPHENYL)ETHANOL 4-Methoxyphenylacetic acid 3-chloro-4-methoxyphenylacetic acid 3-CHLORO-4-ETHOXY-BENZENEACETIC ACID 3-Chlorophenylacetic acid 3-CHLOROPHENETHYLALCOHOL ALCLOFENAC ALLYL 2-CHLOROPHENYL ETHER 4-ETHOXYPHENYLACETIC ACID

4-(Allyloxy)-3-chlorobenzeneacetic acid

2-(3-chloro-4-prop-2-enoxyphenyl)acetic acid

2-(3-chloro-4-prop-2-enoxy-phenyl)ethanoic acid

2-(4-allyloxy-3-chloro-phenyl)acetic acid

3-chloro-4-(2-propenyloxy)-benzeneaceticaci

3-chloro-4-(2-propenyloxy)benzeneaceticacid

4-allyloxy-3-chlorophenyl-aceticaci

Acetic acid, [4-(allyloxy)-3-chlorophenyl]-

Alclophenac

Alcorenac

Allopydin

Argun

Benzeneacetic acid, 3-chloro-4-(2-propenyloxy)-

Epinal

Kyselina 4-allyloxy-3-chlorfenyloctova

kyselina4-allyloxy-3-chlorfenyloctova

Medifenac

Mervan

Neosten

Neoston

Prinalgin

Reufenac

W 7320

w7320

Zumaril

3-Chloro-4-(2-propen-1-yloxy)benzeneacetic Acid

Aclofenac

MY 101

ALCLOFENAC

(4-ALLYLOXY-3-CHLORO-PHENYL)-ACETIC ACID

[3-Chloro-4-(allyloxy)phenyl]acetic acid

3-Chloro-4-(2-propenyloxy)benzeneacetic acid

Benzeneacetic acid, 3-chloro-4-(2-propen-1-yloxy)-

BRN 2116510

Alclofenac, 10 mM in DMSO

22131-79-9

Aromatics

Intermediates & Fine Chemicals

Pharmaceuticals