2-FLUORO-6-HYDROXYBENZONITRILE

Product Name: 2-FLUORO-6-HYDROXYBENZONITRILE
CAS No.: 140675-43-0
Chemical Name: 2-FLUORO-6-HYDROXYBENZONITRILE
Synonyms: 2-CYANO-3-FLUOROPHENOL;6-FLUOROSALICYLONITRILE;2-fuoro-6-hydroxybenzonitrle;2-fluoro-6-hydroxybenzonitrle;2-FLUORO-6-HYDROXYBENZONITRILE;Benzonitrile, 2-fluoro-6-hydroxy-;2-Fluoro-6-hydroxybenzonitrile >2-Fluoro-6-hydroxybenzonitrile 99%;2-FLUORO-6-HYDROXYBENZONITRILE,98+%;Benzonitrile, 2-fluoro-6-hydroxy- (9CI)
CBNumber: CB5494132
Molecular Formula: C7H4FNO
Formula Weight: 137.11
MOL File: 140675-43-0.mol

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2-FLUORO-6-HYDROXYBENZONITRILE Property

Melting point:: 156-158°C
Boiling point:: 257.5±25.0 °C(Predicted)
Density: 1.34±0.1 g/cm3(Predicted)
storage temp.: Inert atmosphere,Room Temperature
solubility: soluble in Methanol
form: powder to crystal
pka: 6.17±0.10(Predicted)
color: White to Light yellow
BRN: 8403914
InChI: InChI=1S/C7H4FNO/c8-6-2-1-3-7(10)5(6)4-9/h1-3,10H
InChIKey: YEBHNFDMNFHZFF-UHFFFAOYSA-N
SMILES: C(#N)C1=C(O)C=CC=C1F
CAS DataBase Reference: 140675-43-0(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 20/22-36/37/38
Safety Statements: 26-36/37/39
RIDADR: 3276
Hazard Note: Irritant
HazardClass: 6.1
PackingGroup: III
HS Code: 2926907090

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H312Harmful in contact with skin

H315Causes skin irritation

H319Causes serious eye irritation

H331Toxic if inhaled

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P405Store locked up.

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N-Bromosuccinimide Price

TCI Chemical

Product number: F0985
Product name: 2-Fluoro-6-hydroxybenzonitrile
Purity: >98.0%(GC)(T)
Packaging: 1g
Price: $21
Updated: 2025/07/31

TCI Chemical

Product number: F0985
Product name: 2-Fluoro-6-hydroxybenzonitrile
Purity: >98.0%(GC)(T)
Packaging: 5g
Price: $84
Updated: 2025/07/31

TRC

Product number: F596183
Product name: 2-Fluoro-6-hydroxybenzonitrile
Packaging: 250mg
Price: $55
Updated: 2021/12/16

TRC

Product number: F596183
Product name: 2-Fluoro-6-hydroxybenzonitrile
Packaging: 1g
Price: $75
Updated: 2021/12/16

Apolloscientific

Product number: PC10435
Product name: 2-Fluoro-6-hydroxybenzonitrile
Purity: 99%
Packaging: 5g
Price: $37
Updated: 2021/12/16

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2-FLUORO-6-HYDROXYBENZONITRILE Chemical Properties,Usage,Production

Chemical Properties

white to light yellow crystal powder

Synthesis

94088-46-7

140675-43-0

General procedure for the synthesis of 2-fluoro-6-hydroxybenzonitrile from 2-fluoro-6-methoxybenzonitrile: 1. 151 g (1 mol) of 2-fluoro-6-methoxybenzonitrile and 346.5 g (3 mol) of aqueous pyridinium solution were added to a 2 liter flask. Hydrogen chloride gas was slowly passed into the flask under a protective atmosphere. 2. The reaction mixture was slowly heated to 190 °C and stirred at this temperature for 5 hours. 3. Upon completion of the reaction, the mixture was cooled to room temperature overnight with slow stirring. 4. 1000 ml of water was added to the cooled mixture, and the mixture was heated to 80 °C. 5. 1000 ml of methyl tert-butyl ether was added and mixed thoroughly to separate the organic and aqueous phases. The aqueous phase was back-extracted twice with 500 ml of methyl tert-butyl ether. 6. Combine all the methyl tert-butyl ether phases and wash once with 800 ml of 10% aqueous sodium hydroxide and once with 400 ml of water. 7. Combine the two aqueous phases and adjust the pH to 2 with concentrated hydrochloric acid, then extract three times with 500 ml of dichloromethane. 8. The organic phases were combined and washed once with 10% hydrochloric acid. 9. The organic phases were dried with anhydrous sodium sulfate. 10. Finally, the solvent was removed by distillation under vacuum to give 120 g (87% yield) of 2-fluoro-6-hydroxybenzonitrile with >99% purity, and the product was confirmed by GC and 1H NMR (D6-dimethylsulfoxide, δ=6.85 ppm (m,2H,aryl H), 7.55 ppm (q,1H,aryl H), 11.7 ppm (s,1H,OH)) structure.

References

[1] Patent: WO2006/56433, 2006, A2. Location in patent: Page/Page column 30
[2] Patent: WO2007/93530, 2007, A1. Location in patent: Page/Page column 244-245

2-FLUORO-6-HYDROXYBENZONITRILE Preparation Products And Raw materials

Raw materials

Preparation Products

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2-FLUORO-6-HYDROXYBENZONITRILE Suppliers

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View Lastest Price from 2-FLUORO-6-HYDROXYBENZONITRILE manufacturers

ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

Product: 2-FLUORO-6-HYDROXYBENZONITRILE 140675-43-0
Price: US $2.00-5.00/kg
Min. Order: 1kg
Purity: 99%
Supply Ability: 100kg
Release date: 2025-06-18

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-FLUORO-6-HYDROXYBENZONITRILE 140675-43-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-10

Zhuozhou Wenxi import and Export Co., Ltd

Product: 2-FLUORO-6-HYDROXYBENZONITRILE 140675-43-0
Price: US $15.00-10.00/KG
Min. Order: 1KG
Purity: 99%+ HPLC
Supply Ability: Monthly supply of 1 ton
Release date: 2021-07-09

140675-43-0, 2-FLUORO-6-HYDROXYBENZONITRILERelated Search:

2-FLUORO-6-(2,2,2-TRIFLUOROETHOXY)BENZONITRILE 2-FLUORO-6-HYDROXYBENZONITRILE 3-FLUORO-4-HYDROXYBENZONITRILE (4-CYANO-2-FLUOROPHENOL),3-FLUORO-4-HYDROXYBENZONITRILE 2,6-Difluoro-4-hydroxybenzonitrile 2-FLUORO-6-PHENOXYBENZONITRILE 2,3-DIFLUORO-6-METHOXYBENZONITRILE 2-Fluoro-6-methoxybenzonitrile 4-Fluoro-3-hydroxybenzonitrile 98%,4-FLUORO-3-HYDROXYBENZONITRILE,4-FLUORO-3-HYDROXYBENZONITRILE 98 3-Fluoro-5-hydroxybenzonitrile 2-Fluoro-4-hydroxybenzonitrile 6-benzyloxy-2-fluorobenzonitrile 2-ETHOXY-6-FLUORO-BENZONITRILE, 98% Benzonitrile, 2,3-difluoro-6-hydroxy- (9CI) 2-FLUORO-6-(4-FLUOROPHENOXY)BENZONITRILE 2-FLUORO-6-(4-METHYLBENZYLOXY)BENZONITRILE 2-FLUORO-6-[4-(METHYLTHIO)PHENOXY]BENZONITRILE 2-FLUORO-6-(4-METHYLPHENOXY)BENZONITRILE 2-FLUORO-6-(4-CHLOROBENZYLOXY)BENZONITRILE

Benzonitrile, 2-fluoro-6-hydroxy- (9CI)

2-FLUORO-6-HYDROXYBENZONITRILE,98+%

2-fuoro-6-hydroxybenzonitrle

2-Fluoro-6-hydroxybenzonitrile 99%

2-fluoro-6-hydroxybenzonitrle

2-Cyano-3-fluorophenol, 6-Fluorosalicylonitrile

6-FLUOROSALICYLONITRILE

2-FLUORO-6-HYDROXYBENZONITRILE

2-CYANO-3-FLUOROPHENOL

Benzonitrile, 2-fluoro-6-hydroxy-

2-Fluoro-6-hydroxybenzonitrile &gt

140675-43-0

C8H5OF

Fluorine series

Aromatic Nitriles

NITRILE