NO-1886

Product Name: NO-1886
CAS No.: 133208-93-2
Chemical Name: NO-1886
Synonyms: NO-1886;OPF 009;ibrolipim;Ibrolipim NO-1886;NO-1886 Ibrolipim;Ibrolipim, 10 mM in DMSO;Lipoprotein Lipase Activator;4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide;Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate;N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide
CBNumber: CB5497355
Molecular Formula: C19H20BrN2O4P
Formula Weight: 451.25
MOL File: 133208-93-2.mol

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NO-1886 Property

Melting point:: 160.5-162.1 °C
Boiling point:: 512.5±50.0 °C(Predicted)
Density: 1.44±0.1 g/cm3(Predicted)
storage temp.: Sealed in dry,2-8°C
solubility: DMSO: ≥20mg/mL
form: powder
pka: 11.51±0.70(Predicted)
color: off-white to pale yellow

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Safety

Hazard Codes: Xi,T
Risk Statements: 36/37/38-25
Safety Statements: 26-36-45
RIDADR: UN 2811 6.1 / PGIII
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word: Danger
Hazard statements: H301Toxic if swalloed
Precautionary statements: P301+P310IF SWALLOWED: Immediately call a POISON CENTER or doctor/physician.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: N1540
Product name: NO-1886
Purity: ≥98% (HPLC)
Packaging: 5mg
Price: $153
Updated: 2025/07/31

Sigma-Aldrich

Product number: N1540
Product name: NO-1886
Purity: ≥98% (HPLC)
Packaging: 25mg
Price: $301.5
Updated: 2025/07/31

Cayman Chemical

Product number: 17425
Product name: NO-1886
Purity: ≥98%
Packaging: 5mg
Price: $86
Updated: 2024/03/01

Cayman Chemical

Product number: 17425
Product name: NO-1886
Purity: ≥98%
Packaging: 10mg
Price: $153
Updated: 2024/03/01

Cayman Chemical

Product number: 17425
Product name: NO-1886
Purity: ≥98%
Packaging: 25mg
Price: $343
Updated: 2024/03/01

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NO-1886 Chemical Properties,Usage,Production

Uses

Antiatherogenic; antiobesity; antidyslipidemia; anticachexia; and antidiabetes/syndrome.

Uses

Lipoprotein Lipase Activator is an inducer of lipoprotein lipase mRNA.

Biological Activity

Lipoprotein lipase activator. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Long-term administration of NO-1886 protects against the development of experimental atherosclerosis in animals.

in vivo

Ibrolipim (NO-1886; 100 mg/kg; oral administration; daily; for 8 weeks; female Sprague-Dawley rats) treatment decreases accumulation of visceral fat and suppresses the increase in body weight resulting from the ovariectomy. Ibrolipim decreases the respiratory quotient and increases expression of the fatty acid translocase messenger RNA (mRNA) in the liver, soleus muscle, and mesenteric fat. Ibrolipim also increases the expression of fatty acid-binding protein mRNA in the liver and soleus muscle and the expression of the uncoupling protein 3 (UCP3) mRNA in the heart, soleus muscle, and mesenteric fat, but not in the brown adipose tissue^[2].

Animal Model:	Female Sprague-Dawley rats (10-week-old; 200-260 g) with experimental ovariectomy treatment^[2]
Dosage:	100 mg/kg
Administration:	Oral administration; daily; for 8 weeks
Result:	Decreased accumulation of visceral fat and suppressed the increase in body weight resulting from the ovariectomy.

NO-1886 Preparation Products And Raw materials

Raw materials

Preparation Products

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NO-1886 Suppliers

China 57 South Korea 1 Switzerland 1 United States 8 Global 67

Nanjing Dulai Biotechnology Co., Ltd.

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Shanghai Hongye Biotechnology Co. Ltd

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HANGZHOU CLAP TECHNOLOGY CO.,LTD

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ChemeGen(Shanghai) Biotechnology Co.,Ltd.

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Absin Bioscience Inc.

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133208-93-2, NO-1886Related Search:

3-Bromobenzonitrile DIETHYL 4-METHYLBENZYLPHOSPHONATE N-(2-cyanophenyl)benzamide 2-AMINO-5-BROMOBENZONITRILE DIMETHYL(4-METHYLBENZYL)PHOSPHONATE (4-METHYLBENZYL)PHOSPHONIC ACID 4-(DIETHYLPHOSPHONOMETHYL)BENZALDEHYDE NO-1886

Ibrolipim NO-1886

OPF 009

Lipoprotein Lipase Activator

N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide

NO-1886

Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate

4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide

ibrolipim

Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate, Ibrolipim, OPF 009

Phosphonic acid, [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]-, diethyl ester

obesity,fatty,inhibit,NO 1886,Ibrolipim,acid,NO1886,Inhibitor,lipoprotein,lipase,Antihyperlipidemic,UCP3,LDL-C,LXRα,HDL-C

NO-1886 Ibrolipim

Diethyl [[4-[[(4-bromo-2-cyanophenyl)amino]carbonyl]phenyl]methyl]phosphonate

Ibrolipim, 10 mM in DMSO

133208-93-2

C19H20BrN2O4P

Br1C19H20N2O4P1