ChemicalBook > CAS DataBase List > NO-1886
NO-1886
- Product Name
- NO-1886
- CAS No.
- 133208-93-2
- Chemical Name
- NO-1886
- Synonyms
- NO-1886;OPF 009;ibrolipim;Ibrolipim NO-1886;NO-1886 Ibrolipim;Ibrolipim, 10 mM in DMSO;Lipoprotein Lipase Activator;4-diethoxyphosphorylmethyl-N-(4-bromo-2-cyanophenyl)benzamide;Diethyl 4-[(4-bromo-2-cyanophenyl)carbamoyl]benzylphosphonate;N-(4-bromo-2-cyanophenyl)-4-(diethoxyphosphorylmethyl)benzamide
- CBNumber
- CB5497355
- Molecular Formula
- C19H20BrN2O4P
- Formula Weight
- 451.25
- MOL File
- 133208-93-2.mol
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NO-1886 Property
- Melting point:
- 160.5-162.1 °C
- Boiling point:
- 512.5±50.0 °C(Predicted)
- Density
- 1.44±0.1 g/cm3(Predicted)
- storage temp.
- Sealed in dry,2-8°C
- solubility
- DMSO: ≥20mg/mL
- form
- powder
- pka
- 11.51±0.70(Predicted)
- color
- off-white to pale yellow
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Safety
- Hazard Codes
- Xi,T
- Risk Statements
- 36/37/38-25
- Safety Statements
- 26-36-45
- RIDADR
- UN 2811 6.1 / PGIII
- WGK Germany
- 3
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N-Bromosuccinimide Price
Sigma-Aldrich
- Product number
- N1540
- Product name
- NO-1886
- Purity
- ≥98% (HPLC)
- Packaging
- 5mg
- Price
- $153
- Updated
- 2025/07/31
Sigma-Aldrich
- Product number
- N1540
- Product name
- NO-1886
- Purity
- ≥98% (HPLC)
- Packaging
- 25mg
- Price
- $301.5
- Updated
- 2025/07/31
Cayman Chemical
- Product number
- 17425
- Product name
- NO-1886
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $86
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17425
- Product name
- NO-1886
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $153
- Updated
- 2024/03/01
Cayman Chemical
- Product number
- 17425
- Product name
- NO-1886
- Purity
- ≥98%
- Packaging
- 25mg
- Price
- $343
- Updated
- 2024/03/01
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NO-1886 Chemical Properties,Usage,Production
Uses
Antiatherogenic; antiobesity; antidyslipidemia; anticachexia; and antidiabetes/syndrome.
Uses
Lipoprotein Lipase Activator is an inducer of lipoprotein lipase mRNA.
Biological Activity
Lipoprotein lipase activator. Overexpression of lipoprotein lipase in transgenic rabbits leads to increased small dense LDL in plasma and promotes atherosclerosis. Long-term administration of NO-1886 protects against the development of experimental atherosclerosis in animals.
in vivo
Ibrolipim (NO-1886; 100 mg/kg; oral administration; daily; for 8 weeks; female Sprague-Dawley rats) treatment decreases accumulation of visceral fat and suppresses the increase in body weight resulting from the ovariectomy. Ibrolipim decreases the respiratory quotient and increases expression of the fatty acid translocase messenger RNA (mRNA) in the liver, soleus muscle, and mesenteric fat. Ibrolipim also increases the expression of fatty acid-binding protein mRNA in the liver and soleus muscle and the expression of the uncoupling protein 3 (UCP3) mRNA in the heart, soleus muscle, and mesenteric fat, but not in the brown adipose tissue[2].
| Animal Model: | Female Sprague-Dawley rats (10-week-old; 200-260 g) with experimental ovariectomy treatment[2] |
| Dosage: | 100 mg/kg |
| Administration: | Oral administration; daily; for 8 weeks |
| Result: | Decreased accumulation of visceral fat and suppressed the increase in body weight resulting from the ovariectomy. |
NO-1886 Preparation Products And Raw materials
Raw materials
Preparation Products
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133208-93-2, NO-1886Related Search:
3-Bromobenzonitrile
DIETHYL 4-METHYLBENZYLPHOSPHONATE
N-(2-cyanophenyl)benzamide
2-AMINO-5-BROMOBENZONITRILE
DIMETHYL(4-METHYLBENZYL)PHOSPHONATE
(4-METHYLBENZYL)PHOSPHONIC ACID
4-(DIETHYLPHOSPHONOMETHYL)BENZALDEHYDE
NO-1886