Calcium folinatc
- Product Name
- Calcium folinatc
- CAS No.
- 6035-45-6
- Chemical Name
- Calcium folinatc
- Synonyms
- Folidan;Foliben;Folaren;NSC-3590;Calcium folitc;Calcium folinatc;Folinic acid calcium salt;Calcium folinatc USP/EP/BP;Leucovorin calcium hydrate;Leucovorin calcium pentahydrate
- CBNumber
- CB5498125
- Molecular Formula
- C20H27CaN7O8
- Formula Weight
- 533.56
- MOL File
- 6035-45-6.mol
Calcium folinatc Property
- Melting point:
- 240-250°C
- alpha
- D21 +14.9° (c = 1 in water)
- storage temp.
- Keep in dark place,Inert atmosphere,2-8°C
- solubility
- insoluble in DMSO; insoluble in EtOH; ≥15.04 mg/mL in H2O with gentle warming
- form
- powder
- color
- Yellow-white to yellow
- InChIKey
- QUCDGUZWVVGQDO-WJYQJPTCNA-N
- SMILES
- C(N1C(CNC2NC(N)=NC(=O)C1=2)CNC1C=CC(C(=O)N[C@H](C(=O)O)CCC(=O)O)=CC=1)=O.[Ca].O |&1:22,r|
Safety
- Hazard Codes
- Xn
- Risk Statements
- 36/37/38-42/43
- Safety Statements
- 26-36
- WGK Germany
- 3
- HS Code
- 29362900
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H315Causes skin irritation
H317May cause an allergic skin reaction
H319Causes serious eye irritation
H334May cause allergy or asthma symptoms or breathing difficulties if inhaled
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P272Contaminated work clothing should not be allowed out of the workplace.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P285In case of inadequate ventilation wear respiratory protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P341IF INHALED: If breathing is difficult, remove victim to fresh air and keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P321Specific treatment (see … on this label).
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P333+P313IF SKIN irritation or rash occurs: Get medical advice/attention.
P342+P311IF experiencing respiratory symptoms: call a POISON CENTER or doctor/physician.
P362Take off contaminated clothing and wash before reuse.
P363Wash contaminated clothing before reuse.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- L330400
- Product name
- LeucovorinCalciumSaltPentahydrate
- Packaging
- 100mg
- Price
- $105
- Updated
- 2021/12/16
- Product number
- F5810
- Product name
- Folinic Acid, Calcium Salt
- Packaging
- 500mg
- Price
- $213
- Updated
- 2021/12/16
- Product number
- L330400
- Product name
- LeucovorinCalciumSaltPentahydrate
- Packaging
- 5g
- Price
- $385
- Updated
- 2021/12/16
- Product number
- CS-1777
- Product name
- Folinicacidcalciumsaltpentahydrate
- Purity
- ≥98.0%
- Packaging
- 500mg
- Price
- $99
- Updated
- 2021/12/16
- Product number
- F367
- Product name
- Calciumfolinatepentahydrate
- Packaging
- 10g
- Price
- $280
- Updated
- 2021/12/16
Calcium folinatc Chemical Properties,Usage,Production
Chemical Properties
yellowish-white to yellow powder
Uses
An intermediate product of the metabolism of Folic Acid. This compound is a mixture of diastereomers.
Uses
Antianemic
brand name
Wellcovorin (GlaxoSmithKline).
Biological Activity
human lymphoid cell lines were studied for leucovorin requirements to protect from methotrexate (mtx)-induced growth suppression. over a 72h continuous exposure leucovorin provided better protection to the cell lines laz-007 and raji than to the cell line
in vivo
Folinic acid (7.0 mg/kg; intraperitoneal injection; every second day; for 3 weeks; Balb/c young growing male mice) treatment following methotrexate (MTX) administration appears to reverse this growth inhibition (Chronic administration of MTX induces suppression of skeletal growth in mice)[2].
| Animal Model: | 24 Balb/c young growing male mice aged 3 weeks (11.88 ± 0.25 g)[2] |
| Dosage: | 7.0 mg/kg |
| Administration: | Intraperitoneal injection; every second day; for 3 weeks |
| Result: | Following methotrexate (MTX) administration appears to reverse this growth inhibition. |
IC 50
Human Endogenous Metabolite
Calcium folinatc Preparation Products And Raw materials
Raw materials
Preparation Products
Calcium folinatc Suppliers
- Tel
- 13464671885 13032431717
- sale@jhssw.com
- Country
- China
- ProdList
- 45
- Advantage
- 58
- Tel
- 15871464247 17307245989
- 3471278124@qq.com
- Country
- China
- ProdList
- 4995
- Advantage
- 58
- Tel
- 18210857532; 18210857532
- Fax
- 86-10-82849933
- jkinfo@jkchemical.com
- Country
- China
- ProdList
- 96815
- Advantage
- 76
- Tel
- 021-50135380
- shchemsky@sina.com
- Country
- China
- ProdList
- 32321
- Advantage
- 50
- Tel
- 0086-21-58956006
- Fax
- 0086-21-58956100
- Country
- China
- ProdList
- 7811
- Advantage
- 57
- Tel
- 0411-62910999 13889544652
- sales@meilune.com
- Country
- China
- ProdList
- 4747
- Advantage
- 58
- Tel
- 86-21-34053660
- Fax
- 86-21-34053661
- sale@labgogo.com
- Country
- China
- ProdList
- 9865
- Advantage
- 52
- Tel
- 800-810-5118
- Fax
- +86-10-84193589
- cnchemical@thermofisher.com
- Country
- China
- ProdList
- 17770
- Advantage
- 75
- Tel
- 025-66113011 17798518460
- Fax
- (1)02557626880
- cfzhang@aikonchem.com
- Country
- China
- ProdList
- 19913
- Advantage
- 55
- Tel
- 021-58950125
- Fax
- (86) 21-58955996
- info@chemexpress.com
- Country
- China
- ProdList
- 7552
- Advantage
- 61
View Lastest Price from Calcium folinatc manufacturers
- Product
- Calcium folinatc 6035-45-6
- Price
- US $0.00/Kg/Bag
- Min. Order
- 1KG
- Purity
- 95%-105%
- Supply Ability
- 100kgs
- Release date
- 2021-09-29
- Product
- Calcium folinatc 6035-45-6
- Price
- US $1.10/g
- Min. Order
- 1g
- Purity
- 99.9%
- Supply Ability
- 100 Tons min
- Release date
- 2021-07-30
- Product
- Calcium folinatc 6035-45-6
- Price
- US $15.00-10.00/KG
- Min. Order
- 1KG
- Purity
- 99%+ HPLC
- Supply Ability
- Monthly supply of 1 ton
- Release date
- 2021-07-10