GW8510

Product Name: GW8510
CAS No.: 222036-17-1
Chemical Name: GW8510
Synonyms: GW-8510 (GW8510;4-(((7-Oxo-6,7-dihydro-8H-thiazolo[5,4-e]indol-8-ylidene)methyl)amino)-N-(pyridin-2-yl)benzenesulfonamide;4-{[(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-n-(2-pyridyl)benzenesulfonamide;Benzenesulfonamide, 4-[[(6,7-dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinyl-
CBNumber: CB5498145
Molecular Formula: C21H15N5O3S2
Formula Weight: 449.51
MOL File: 222036-17-1.mol

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GW8510 Property

Density: 1.635±0.06 g/cm3(Predicted)
storage temp.: room temp
solubility: DMSO: soluble
form: solid
pka: 8.39±0.10(Predicted)
color: Light yellow to yellow

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Safety

WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: KIN0000124
Product name: GW8510
Purity: 95.00%
Packaging: 1MG
Price: $651.13
Updated: 2021/12/16

American Custom Chemicals Corporation

Product number: KIN0000124
Product name: GW8510
Purity: 95.00%
Packaging: 5MG
Price: $967.48
Updated: 2021/12/16

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GW8510 Chemical Properties,Usage,Production

Uses

GW8510 is a potent cyclin-dependent kinase-2 (CDK2) inhibitor. GW8510 is also a ribonucleotide reductase M2 (RRM2) inhibitor. GW8510 exhibits neuroprotective and anticancer activities[1][2][3].

Definition

ChEBI: 4-[(7-oxo-6H-pyrrolo[2,3-g][1,3]benzothiazol-8-ylidene)methylamino]-N-(2-pyridinyl)benzenesulfonamide is a sulfonamide and a member of benzenes.

Biochem/physiol Actions

Initially characterized as an inhibitor of cyclin-dependent kinase 2 (CDK2), subsequent research has shown GW8510 to be non-selective.

in vivo

Combination with GW8510 and Tamoxifen enhances tumoricidal effect on Tamoxifen-resistant BBC xenograft through autophagy induction^[3].

IC 50

CDK2; CDK5; RRM2

References

[1] ARCAMONE F, et, al. STRUCTURE AND SYNTHESIS OF DISTAMYCIN A. Nature. 1964 Sep 5;203:1064-5. DOI:10.1038/2031064a0
[2] Hiraku Y, et, al. Distamycin A, a minor groove binder, changes enediyne-induced DNA cleavage sites and enhances apoptosis. Nucleic Acids Res Suppl. 2002;(2):95-6. DOI:10.1093/nass/2.1.95
[3] Majumder P, et, al. Effect of DNA groove binder distamycin A upon chromatin structure. PLoS One. 2011;6(10):e26486. DOI:10.1371/journal.pone.0026486

GW8510 Preparation Products And Raw materials

Raw materials

Preparation Products

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GW8510 Suppliers

China 26 South Korea 1 Switzerland 1 United States 5 Global 33

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 32159
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InvivoChem

Tel: +1-708-310-1919 +1-13798911105
Fax: 708-557-7486
Email: sales@invivochem.cn
Country: United States
ProdList: 6391
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TargetMol Chemicals Inc.

Tel: +8613564774135
Email: zijue.cai@tsbiochem.com
Country: United States
ProdList: 19881
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Aladdin Scientific

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Email: tp@aladdinsci.com
Country: United States
ProdList: 52924
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Riedel-de Haen AG

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Country: United States
ProdList: 6773
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222036-17-1, GW8510Related Search:

GW-8510 (GW8510

4-{[(7-oxo-6,7-dihydro-8h-[1,3]thiazolo[5,4-e]indol-8-ylidene)methyl]amino}-n-(2-pyridyl)benzenesulfonamide

Benzenesulfonamide, 4-[[(6,7-dihydro-7-oxo-8H-pyrrolo[2,3-g]benzothiazol-8-ylidene)methyl]amino]-N-2-pyridinyl-

4-(((7-Oxo-6,7-dihydro-8H-thiazolo[5,4-e]indol-8-ylidene)methyl)amino)-N-(pyridin-2-yl)benzenesulfonamide

222036-17-1