LFM-A13

Product Name: LFM-A13
CAS No.: 244240-24-2
Chemical Name: LFM-A13
Synonyms: LFM-A13(Z);2-cyano-N-(2,5-dibromophenyl) -3-oxobutanamide;(Z)-2-yano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide;(Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide;(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide;a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide;α-cyano-β-hydroxy-β-methyl-n-(2,5-dibromophenyl)propenamide;2-Butenamide,2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-, (2Z)-;(Z)-2-cyano-N-(2,5-dibroMophenyl)-3-hydroxybut-2-enaMide(LFM-A13)
CBNumber: CB5498231
Molecular Formula: C11H8Br2N2O2
Formula Weight: 360
MOL File: 244240-24-2.mol

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LFM-A13 Property

Melting point:: 150-151 °C
Boiling point:: 487.9±45.0 °C(Predicted)
Density: 1.909±0.06 g/cm3(Predicted)
storage temp.: −20°C
solubility: DMSO: 15 mg/mL
pka: 5.20±0.50(Predicted)
form: powder
color: white
Stability:: Stable for 2 years from date of purchase as supplied. PROTECT FROM MOISTURE. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

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Safety

Hazard Codes: Xn
Risk Statements: 20/21/22
Safety Statements: 36/37
WGK Germany: 3

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: L6920
Product name: LFM-A13
Purity: ≥98% (HPLC), powder
Packaging: 5mg
Price: $106
Updated: 2024/03/01

Sigma-Aldrich

Product number: L6920
Product name: LFM-A13
Purity: ≥98% (HPLC), powder
Packaging: 25mg
Price: $458
Updated: 2022/05/15

Cayman Chemical

Product number: 10010265
Product name: LFM-A13
Purity: ≥98%
Packaging: 5mg
Price: $68
Updated: 2024/03/01

Cayman Chemical

Product number: 10010265
Product name: LFM-A13
Purity: ≥98%
Packaging: 10mg
Price: $130
Updated: 2024/03/01

Cayman Chemical

Product number: 10010265
Product name: LFM-A13
Purity: ≥98%
Packaging: 50mg
Price: $535
Updated: 2024/03/01

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LFM-A13 Chemical Properties,Usage,Production

Description

LFM-A13 (244240-24-2) is a selective inhibitor of Bruton’s tyrosine kinase (BTK) – IC50‘s = 2.5 μM (recombinant BTK) and 17.2 μM (human BTK).1,2 It has also been shown to inhibit Polo-like kinase (PLK) – IC50 = 61 μM for human PLK3.3 LFM-A13 displayed no activity (concentrations up to 278 μM) at JAK1, JAK3, HCK, EGFRK and IRK2 or CDK1-3, CHK1, IKK, MAPK1, SAPK2a and ten other tyrosine kinases.3

Uses

LFM-A13 is a potent inhibitor of Polo-like kinase (PLK), used for anti-breast cancer activity. Also a specific Bruton’s tyrosine kinase inhibitor.

in vitro

lfm-a13 inhibited recombinant btk expressed in a baculovirus expression vector system. besides its remarkable potency in btk kinase assays, lfm-a13 was also found to be a highly specific inhibitor of btk. even at very high concentrations, lfm-a13 did not affect the activity of other protein tyrosine kinases [1].

in vivo

lfm-a13 exhibited a favorable pharmacokinetic behavior which was not adversely affected by the standard chemotherapy drugs and significantly improved the chemotherapy response and survival outcome of bcl-1 leukemia cells challenged mice. while only 14% of mice treated with the standard triple-drug combination treatment became long-term survivors, 41% of mice treated with this combination plus lfm-a13 survived long-term [2].

IC 50

17.2 μm

References

1) Vassilev et al. (1999), Bruton’s tyrosine kinase as an inhibitor of the Fas/CD95 death-inducing signaling complex; J. Biol. Chem., 274 1646 2) Mahajan et al. (1999), Rational design and synthesis of a novel-anti-leukemic agent targeting Bruton’s tyrosine kinase (BTK), LFM-A13 [α-cyano-β-hydroxy-β-methyl-N-(2,5-dibromophenyl)propenamide]; J. Biol. Chem. 274 9587 3) Uckun et al. (2007) Anti-breast cancer activity of LFM-A13, a potent inhibitor of polo-like kinase (PLK); Bioorg. Med. Chem. 15 800

LFM-A13 Preparation Products And Raw materials

Raw materials

Preparation Products

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LFM-A13 Suppliers

Canada 1 China 64 Switzerland 1 United States 14 Global 80

MedChemexpress LLC

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Aladdin Scientific

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MedChemExpress

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Riedel-de Haen AG

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View Lastest Price from LFM-A13 manufacturers

Career Henan Chemical Co

Product: LFM-A13 244240-24-2
Price: US $1.00/KG
Min. Order: 1KG
Purity: 98-100%
Supply Ability: 1000kg
Release date: 2018-08-20

244240-24-2, LFM-A13Related Search:

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LFM-A13(Z)

2-Butenamide,2-cyano-N-(2,5-dibromophenyl)-3-hydroxy-, (2Z)-

α-cyano-β-hydroxy-β-methyl-n-(2,5-dibromophenyl)propenamide

(Z)-2-cyano-N-(2,5-dibroMophenyl)-3-hydroxybut-2-enaMide(LFM-A13)

(Z)-2-cyano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide

(2Z)-2-Cyano-N-(2,5-dibromophenyl)-3-hydroxy-2-butenamide

a-Cyano-b-hydroxy-b-methyl-N-(2,5-dibromophenyl)propenamide

2-cyano-N-(2,5-dibromophenyl) -3-oxobutanamide

(Z)-2-yano-N-(2,5-dibromophenyl)-3-hydroxybut-2-enamide

244240-24-2

Inhibitors