TRIPARANOL

Product Name: TRIPARANOL
CAS No.: 78-41-1
Chemical Name: TRIPARANOL
Synonyms: mer29;MER 2p;Clotrox;Diticyl;nsc65345;Drenaren;Metasqua;Acosterina;Metasclene;metasqualene
CBNumber: CB5498433
Molecular Formula: C27H32ClNO2
Formula Weight: 438
MOL File: 78-41-1.mol

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TRIPARANOL Property

Melting point:: 102.9-103.7 °C
Density: 1.0173 (rough estimate)
refractive index: 1.5830 (estimate)
storage temp.: 2-8°C
solubility: DMSO: 15 mg/mL
Boiling point:: 235-240 °C(Press: 0.08 Torr)
pka: 13.44±0.29(Predicted)
form: solid
color: off-white

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Safety

Hazard Codes: Xn
Risk Statements: 22-41
Safety Statements: 26-39
WGK Germany: 3
RTECS: KK2400000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Danger

Hazard statements

H302Harmful if swallowed

H318Causes serious eye damage

Precautionary statements

P280Wear protective gloves/protective clothing/eye protection/face protection.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: T5200
Product name: Triparanol
Purity: ≥97% (HPLC), powder
Packaging: 5mg
Price: $214
Updated: 2024/03/01

Sigma-Aldrich

Product number: T5200
Product name: Triparanol
Purity: ≥97% (HPLC), powder
Packaging: 25mg
Price: $468.6
Updated: 2024/03/01

Cayman Chemical

Product number: 20918
Product name: Triparanol
Purity: ≥98%
Packaging: 500μg
Price: $54
Updated: 2024/03/01

Cayman Chemical

Product number: 20918
Product name: Triparanol
Purity: ≥98%
Packaging: 1mg
Price: $94
Updated: 2024/03/01

Cayman Chemical

Product number: 20918
Product name: Triparanol
Purity: ≥98%
Packaging: 5mg
Price: $207
Updated: 2024/03/01

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TRIPARANOL Chemical Properties,Usage,Production

Originator

Mer-29,Merrell National,US,1960

Uses

Desmosterol Delta 24 (D24) reductase inhibitor

Uses

Triparanol has been used to inhibit cholesterol biosynthesis in lipid rafts¹. Triparanol has also been used as a 3β-hydroxysterol-Δ24-reductase inhibitor to study its effect on delayed-rectifier potassium current (I_ks) channels².

Definition

ChEBI: Triparanol is a stilbenoid. It has a role as an anticoronaviral agent.

Manufacturing Process

4-(β-diethylaminoethoxy)-4-methylbenzophenone was prepared as follows: a mixture of 200 g of 4-hydroxy-4-methylbenzophenone, 55 g of powdered sodium methoxide and 400 ml of ethanol was stirred for 30 minutes. A solution of 150 g of β-diethylaminoethyl chloride in 300 ml of toluene was added and the mixture was refluxed four hours. The solvent was removed, the residue was taken up in ether, extracted with 5% NaOH solution, twice with water, the ether was removed and the residue was distilled. The product was obtained as an oil boiling at 232°C at 0.6 mm.
1 liter of a 0.45 N ethereal solution of p-chlorobenzyl magnesium chloride was added in 30 minutes to a stirred solution of 104 g (0.35 mol) of 4-(β- diethylaminoethoxy)-4-methylbenzophenone in 400 ml of dry ether. After stirring an additional hour, the mixture was decomposed by pouring onto 1 liter of cold 10% ammonium chloride solution, the ether solution was washed with water, and the ether was replaced with hot isopropanol containing a trace of ammonia. 1-[p-(β-diethylaminoethoxy)phenyl]-1-phenyl-2-p-tolyl-2-p_x0002_chloroethanol separated as white crystals, melting at 104% to 106°C.

Therapeutic Function

Antihyperlipidemic

Biochem/physiol Actions

Triparanol is known to repress Hedgehog signaling in cancer cells and can also inhibit tumor growth3.

TRIPARANOL Preparation Products And Raw materials

Raw materials

Preparation Products

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TRIPARANOL Suppliers

Canada 1 China 20 India 3 Switzerland 1 United Kingdom 1 United States 6 USA 1 Global 33

J & K SCIENTIFIC LTD.

Tel: 010-82848833 400-666-7788
Fax: 86-10-82849933
Email: jkinfo@jkchemical.com
Country: China
ProdList: 94838
Advantage: 76

Chemsky (shanghai) International Co.,Ltd

Tel: 021-50135380
Email: shchemsky@sina.com
Country: China
ProdList: 15421
Advantage: 60

Guangzhou Isun Pharmaceutical Co., Ltd

Tel: 020-39119399 18927568969
Fax: 020-39119999
Email: isunpharm@qq.com
Country: China
ProdList: 4428
Advantage: 55

Sigma-Aldrich

Tel: 021-61415566 800-8193336
Email: orderCN@merckgroup.com
Country: China
ProdList: 51471
Advantage: 80

Aikon International Limited

Tel: 025-58859352 18068836627
Fax: 02557626880
Email: sales01@aikonchem.com
Country: China
ProdList: 15085
Advantage: 58

Shanghai Jizhi Biochemical Technology Co. Ltd.

Tel: 400-400-400-9004166 18616739031
Email: 3007523370@qq.com
Country: China
ProdList: 52712
Advantage: 58

Shanghai Hongye Biotechnology Co. Ltd

Tel: 400-9205774
Email: sales@glpbio.cn
Country: China
ProdList: 6870
Advantage: 58

Shenzhen Polymeri Biochemical Technology Co., Ltd.

Tel: +86-400-002-6226 13028896684
Email: sales@rrkchem.com
Country: China
ProdList: 55791
Advantage: 58

TargetMol Chemicals Inc.

Tel: +1-781-999-5354 +1-00000000000
Email: marketing@targetmol.com
Country: United States
ProdList: 19892
Advantage: 58

ChemeGen(Shanghai) Biotechnology Co.,Ltd.

Tel: 18818260767
Fax: QQ 3610331285
Email: sales@chemegen.com
Country: China
ProdList: 11289
Advantage: 58

78-41-1, TRIPARANOLRelated Search:

Peramivir 1,1,2-triphenylethanol 4-Methylbenzhydrol 4-METHOXY-4'-METHYLBENZHYDROL Tesmilifene 2-(4-CHLOROPHENYL)-1,1-DIPHENYLETHANOL 1,2-Diphenyl-1-(4-hydroxyphenyl)ethanol [4-[2-(DIMETHYLAMINO)ETHOXY]PHENYL]METHANOL 1-(4-Chlorophenyl)-2-methyl-2-propanol TRIPARANOL

Benzeneethanol, 4-chloro-α-[4-[2-(diethylamino)ethoxy]phenyl]-α-(4-methylphenyl)-

1-(p-(beta-diethylaminoethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol

2-(p-chlorophenyl)-1-(p-(2-(diethylamino)ethoxy)phenyl)-1-p-tolyl-ethano

2-(p-chlorophenyl)-1-(p-(beta-diethylaminoethoxy)phenyl)-1-(p-tolyl)ethanol

2-p-chlorophenyl-1-(p-(2-diethylaminoethoxy)phenyl)-1-p-tolylethanol

alpha-(p-chlorobenzyl)-4-diethylaminoethoxy-4’-methylbenzhydrol

mer29

metasqualene

nsc65345

4-Chloro-α-[4-[2-(diethylamino)ethoxy]phenyl]-α-(4-methylphenyl)benzeneethanol

Acosterina

Clotrox

Diticyl

Drenaren

Hipocolestina

MER 2p

Metasclene

Metasqua

4-Chloro-a-[4-[2-(diethylamino)ethoxy]phenyl]-a-(4-methylphenyl)benzeneethanol

2-(4-chlorophenyl)-1-[4-(2-diethylaminoethyloxy)phenyl]-1-(4-methylphenyl)ethanol

1-(4-(2-(diethylamino)ethoxy)phenyl)-1-(p-tolyl)-2-(p-chlorophenyl)ethanol

Benzeneethanol,4-chloro-a-[4-[2-(diethylamino)ethoxy]phenyl]-a-(4-methylphenyl)-

PTCH1,Hedgehog,24-DHCR,Triparanol,cholesterol biosynthesis,MER-29,inhibit,Apoptosis,tumor growth,Inhibitor,MER 29,MER29

78-41-1

C27H32NO2Cl

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