1-(4-Chlorophenyl)-2-methyl-2-propanol
- Product Name
- 1-(4-Chlorophenyl)-2-methyl-2-propanol
- CAS No.
- 5468-97-3
- Chemical Name
- 1-(4-Chlorophenyl)-2-methyl-2-propanol
- Synonyms
- 2-(4-Chlorobenzyl)-2-propanol;4-Chloro-α,α-dimethylbenzeneethanol;4-Chloro-α,α-dimethylphenethyl alcohol;1-(4-CHLOROPHENYL)-2-METHYL-2-PROPANOL;2-(4-Chlorophenyl)-1,1-diMethylethanol;1-(4-chlorophenyl)-2-methylpropan-2-ol;1-(4-chlorophenyl)-2-methyl-propan-2-ol;4-chloro-α,α-dimethylphenethylic alcohol;4-chloro-alpha,alpha-dimethylphenethylic alcohol;1-(4-Chlorophenyl)-2-methylpropan-2-ol, 1-(Chlorophenyl)-2-hydroxy-2-methylpropane
- CBNumber
- CB7926619
- Molecular Formula
- C10H13ClO
- Formula Weight
- 184.66
- MOL File
- 5468-97-3.mol
1-(4-Chlorophenyl)-2-methyl-2-propanol Property
- Melting point:
- 34°C
- Boiling point:
- 263.92°C (rough estimate)
- Density
- 1.0639 (rough estimate)
- refractive index
- 1.5310 (estimate)
- storage temp.
- Sealed in dry,Room Temperature
- solubility
- DCM
- form
- Oil
- color
- Orange
- NIST Chemistry Reference
- P-chloro-«alpha»,«alpha»-dimethylphenethyl alcohol(5468-97-3)
Safety
- HS Code
- 2907290090
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H312Harmful in contact with skin
H332Harmful if inhaled
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P312Call a POISON CENTER or doctor/physician if you feel unwell.
P330Rinse mouth.
P362Take off contaminated clothing and wash before reuse.
P403+P233Store in a well-ventilated place. Keep container tightly closed.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- C422220
- Product name
- 2-(4-Chlorophenyl)-1,1-dimethylethanol
- Packaging
- 5g
- Price
- $475
- Updated
- 2021/12/16
- Product number
- 2703-5-01
- Product name
- 4-Chloro-alpha,alpha-dimethylphenethyl alcohol
- Purity
- 96%
- Packaging
- 1g
- Price
- $152
- Updated
- 2021/12/16
- Product number
- Q321
- Product name
- 1-(4-Chlorophenyl)-2-methyl-2-propanol
- Packaging
- 1g
- Price
- $210
- Updated
- 2021/12/16
- Product number
- HCH0037182
- Product name
- 1-(4-CHLOROPHENYL)-2-METHYL-2-PROPANOL
- Purity
- 95.00%
- Packaging
- 1G
- Price
- $231
- Updated
- 2021/12/16
- Product number
- 44646
- Product name
- 2-(4-Chlorophenyl)-1,1-dimethylethanol
- Packaging
- 10g
- Price
- $1250
- Updated
- 2021/12/16
1-(4-Chlorophenyl)-2-methyl-2-propanol Chemical Properties,Usage,Production
Uses
2-(4-Chlorophenyl)-1,1-dimethylethanol is an intermediate in the synthesis of Chlorphentermine (C375080), anorectic agent that is structurally related to amphetamine.
Synthesis
104-83-6
5468-97-3
Example 1: Synthesis of 1-(4-chlorophenyl)-2-methyl-2-propanol 1. In a three-necked flask equipped with a stirrer and reflux condenser, a solution of 4-chlorobenzyl chloride (165 g, 1.02 mol) in ether (500 ml) was added. 2. Magnesium flakes (24.3 g, 1.00 mol) were added slowly and dropwise over a period of 1 h. The reaction mixture began to reflux spontaneously. 3. After continuing to reflux for 1 hr, the reaction solution was cooled to room temperature. 4. 4. add acetone (60.0 g, 1.30 mol) dropwise to the reaction mixture. 5. Heat the reaction mixture to reflux for 3 hours. 6. 6. Upon completion of the reaction, the reaction mixture was cooled and poured into a mixture of ice (500 ml) and concentrated hydrochloric acid (92 ml). 7. Separate the organic and aqueous phases. 8. The organic phase was washed with water and subsequently dried with anhydrous sodium sulfate. 9. The solvent was removed by vacuum evaporation to give the crude product. 10. The crude product was purified by fractional distillation and the fractions with a boiling point of 123°-124 °C/12 mmHg were collected to give 1-(4-chlorophenyl)-2-methyl-2-propanol (nD25 = 1.5300; 128.5 g, 70% yield).
References
[1] Patent: US4237311, 1980, A
1-(4-Chlorophenyl)-2-methyl-2-propanol Preparation Products And Raw materials
Raw materials
Preparation Products
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View Lastest Price from 1-(4-Chlorophenyl)-2-methyl-2-propanol manufacturers
- Product
- 1-(4-Chlorophenyl)-2-methyl-2-propanol 5468-97-3
- Price
- US $1.00/KG
- Min. Order
- 1KG
- Purity
- 98%HPLC
- Supply Ability
- 10tons
- Release date
- 2020-01-10