N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN&

Product Name: N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN&
CAS No.: 215178-45-3
Chemical Name: N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN&
Synonyms: N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN&;(R)-1-Fmoc-2-(hydroxymethyl)-pyrrolidine;(R)-(9H-Fluoren-9-yl)Methyl 2-(hydroxyMethyl)pyrrolidine-1-carboxylate;(9h-Fluoren-9-yl)methyl (r)-2-(hydroxymethyl)pyrrolidine-1-carboxylate;1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-, 9H-fluoren-9-ylmethyl ester, (2R)-
CBNumber: CB5499506
Molecular Formula: C20H21NO3
Formula Weight: 323.39
MOL File: 215178-45-3.mol

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N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN& Property

storage temp.: Sealed in dry,Store in freezer, under -20°C

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

American Custom Chemicals Corporation

Product number: AAA0002546
Product name: FMOC-D-PROLINOL
Purity: 95.00%
Packaging: 1G
Price: $673.08
Updated: 2021/12/16

ACHEMBLOCK

Product number: P39729
Product name: (R)-1-Fmoc-2-(hydroxymethyl)-pyrrolidine
Purity: 95%
Packaging: 1G
Price: $120
Updated: 2021/12/16

Crysdot

Product number: CD11165539
Product name: (R)-(9H-Fluoren-9-yl)methyl2-(hydroxymethyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 5g
Price: $223
Updated: 2021/12/16

Alichem

Product number: 215178453
Product name: (R)-(9H-Fluoren-9-yl)methyl2-(hydroxymethyl)pyrrolidine-1-carboxylate
Packaging: 5g
Price: $229.5
Updated: 2021/12/16

Crysdot

Product number: CD11165539
Product name: (R)-(9H-Fluoren-9-yl)methyl2-(hydroxymethyl)pyrrolidine-1-carboxylate
Purity: 95+%
Packaging: 10g
Price: $376
Updated: 2021/12/16

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N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN& Chemical Properties,Usage,Production

Synthesis

71989-31-6

215178-45-3

GENERAL METHODS: (S)- or (R)-Fmoc-proline (4.58 g, 13.6 mmol) was dissolved in anhydrous THF (125 mL) in a round-bottomed flask with a magnetic stirrer and protected by nitrogen. The reaction solution was cooled to 0 °C, followed by slow addition of NaBH4 (0.82 g, 21.7 mmol). After the reaction mixture was stirred at 0 °C for 60 min, boron trifluoride diethyl ether compound (3.4 mL, 3.85 g, 27.1 mmol) was added dropwise and stirring was continued for 18 h at 0 °C. The reaction progress was monitored by TLC (CH2Cl2/EtOAc 70:30). Upon completion of the reaction, water (30 mL) was added at 0 °C and the mixture was stirred for 30 min. Subsequently, THF was removed by vacuum evaporation and the remaining aqueous layer was extracted with EtOAc (3 x 100 mL). The organic phases were combined, washed with saturated saline, dried over anhydrous Na2SO4 and filtered. The solvent was concentrated under reduced pressure and the crude product was purified by fast chromatography using a gradient of CH2Cl2:EtOAc (95:5→85:15) as eluent. Finally, the product was precipitated with cold hexane to give (R)-N-Fmoc-pyrrolidine-2-methanol in white powder form, stored at -15 °C.

References

[1] Tetrahedron, 2017, vol. 73, # 32, p. 4707 - 4718

N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN& Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN& Suppliers

China 14 India 1 Switzerland 1 United States 4 Global 20

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215178-45-3, N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN&Related Search:

FMOC-D-PRO(4,4-DIFLUORO) (2R,5S)-FMOC-5-PHENYL-PYRROLIDINE-2-CARBOXYLIC ACID FMOC-D-PRO-OPFP FMOC-D-CIS-HYP-OH FMOC-D-HYP(TBU)-OH FMOC-(2R,4R)-PRO(4-F)-OH FMOC-(2R,4S)-PRO(4-F)-OH FMOC-D-HYP(BZL)-OH N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN& FMOC-(2R,3S)-3-PROLINOMETHIONINE (CIS) FMOC-(2R,3S)-3-PROLINOVALINE (CIS) (2R,4S)-N-ALPHA-(9-FLUORENYLMETHOXYCARBONYL)-4-HYDROXYPYRROLIDINE-2-CARBOXYLIC ACID Fmoc-D-proline FMOC-D-CIS-4-HYDROXYPROLINE METHYL ESTER FMOC-D-PRO(4-OXO)

N-(9-FLUORENYLMETHOXYCARBONYL)-D-PROLIN&

(R)-(9H-Fluoren-9-yl)Methyl 2-(hydroxyMethyl)pyrrolidine-1-carboxylate

(R)-1-Fmoc-2-(hydroxymethyl)-pyrrolidine

1-Pyrrolidinecarboxylic acid, 2-(hydroxymethyl)-, 9H-fluoren-9-ylmethyl ester, (2R)-

(9h-Fluoren-9-yl)methyl (r)-2-(hydroxymethyl)pyrrolidine-1-carboxylate

215178-45-3