Anecortave Acetate
- Product Name
- Anecortave Acetate
- CAS No.
- 7753-60-8
- Chemical Name
- Anecortave Acetate
- Synonyms
- H6;Anecortave;Pregna-4,9(11)-diene-17-ol-3,20-dione-21-acetate;Al 3789;Retaane;NSC 15475;NSC 24345;Anacorta acetate;Anechota acetate;anecortave acetate
- CBNumber
- CB5501441
- Molecular Formula
- C23H30O5
- Formula Weight
- 386.48
- MOL File
- 7753-60-8.mol
Anecortave Acetate Property
- Melting point:
- 230-234°C
- alpha
- D +117° (c = 1.0 in CHCl3); D22 +124° (c = 1.04 in CHCl3).
- Boiling point:
- 551.8±50.0 °C(Predicted)
- Density
- 1.23±0.1 g/cm3(Predicted)
- storage temp.
- -20°C Freezer
- solubility
- Chloroform (Slightly), Methanol (Slightly)
- pka
- 12.47±0.60(Predicted)
- form
- Solid
- color
- Off-White to Beige
N-Bromosuccinimide Price
- Product number
- A637640
- Product name
- Anecortave
- Packaging
- 1g
- Price
- $900
- Updated
- 2021/12/16
- Product number
- SHG0000670
- Product name
- 17-HYDROXY-3,20-DIOXOPREGNA-4,9(11)-DIEN-21-YL ACETATE
- Purity
- 95.00%
- Packaging
- 100MG
- Price
- $1871.1
- Updated
- 2021/12/16
- Product number
- FA17919
- Product name
- Anecortave acetate
- Packaging
- 25g
- Price
- $60
- Updated
- 2021/12/16
- Product number
- FA17919
- Product name
- Anecortave acetate
- Packaging
- 50g
- Price
- $107.5
- Updated
- 2021/12/16
- Product number
- 8015CA
- Product name
- Anecortaveacetate
- Packaging
- 25g
- Price
- $131
- Updated
- 2021/12/16
Anecortave Acetate Chemical Properties,Usage,Production
Description
Anecortave acetate, an angiogenesis inhibitor, was launched in Australia by Alcon for the treatment of age-related macular degeneration (AMD). AMD is the leading cause of untreatable blindness among people aged 65 to 74 years in the U.S. Worldwide, approximately 20 to 25 million people suffer from AMD, a disease that until recently was untreatable. Anecortave, an angiostatic steroid, down-regulates the expression MMP-2 and -9 to exert its antiangiogenic effects.
Chemical Properties
Off-White Solid
Uses
As an angiostatic steroid, Anecortave Acetate can be used in treatment of macular degeneration.
Definition
ChEBI: Anecortave acetate is an organic molecular entity.
Synthesis
Anecortave has been synthesized by several different routes, and Pharmacia process patents are cited here. The synthesis is depicted in the scheme. Compound 1 was condensed with 2-chlorovinyl ethyl ether with n-BuLi in THF at low temperature to give a mixture of two isomeric aldehydes 2 in 91% yield. The mixture 2 was treated with acetic anhydride and anhydrous potassium acetate in DMF at 106??C to give acetate 3 which was reacted with RhCl(PPh3)3 and triethylsilane in methylene chloride at 45??C for 4 hours to yield the corresponding triethylsilane ether 4 as a solid after crystallization in hexane. Finally, compound 4 was oxidized with 40% peracetic acid in toluene at low temperature, and the reaction was quenched with SO2 in methanol (2M), and treated with TEA to give anecortave acetate
Enzyme inhibitor
This novel angiogenesis pro-drug (FW = 386.48 g/mol; CAS 7753-60-8) is taken up and metabolically de-esterified to form the aqnecortave, a synthetic steroid that suppresses the development and elongation of neovascular sprouts and tip cell motility in a VEGF-treated retinal explant model in a dose-dependent manner. Whether used as monotherapy or in combination with sub-therapeutic doses of cisplatin, anecortave acetate significantly controlled tumor burden in a murine retinoblastoma model.
Anecortave Acetate Preparation Products And Raw materials
Raw materials
Preparation Products
Anecortave Acetate Suppliers
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View Lastest Price from Anecortave Acetate manufacturers
- Product
- Anecortave Acetate(H5) 7753-60-8
- Price
- US $40.00/KG
- Min. Order
- 1KG
- Purity
- 99.9%
- Supply Ability
- 1000
- Release date
- 2024-03-21
- Product
- Anecortave Acetate 7753-60-8
- Price
- US $30.00/kg
- Min. Order
- 1kg
- Purity
- 98%
- Supply Ability
- 2000kg
- Release date
- 2024-05-16
- Product
- Anecortave Acetate 7753-60-8
- Price
- US $40.00/kg
- Min. Order
- 1kg
- Purity
- 0.99
- Supply Ability
- 10 tons
- Release date
- 2023-09-08