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6-chloro-3-nitroimidazo[1,2-b]pyridazine

Product Name
6-chloro-3-nitroimidazo[1,2-b]pyridazine
CAS No.
18087-76-8
Chemical Name
6-chloro-3-nitroimidazo[1,2-b]pyridazine
Synonyms
6-Chloro-3-nitroimidazo[1,2-b]pyridazine;6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN;Imidazo[1,2-b]pyridazine, 6-chloro-3-nitro-;6-Chloro-3-nitro-imidazo[1,2-b<;6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN ISO 9001：2015 REACH
CBNumber
CB5502493
Molecular Formula
C6H3ClN4O2
Formula Weight
198.57
MOL File
18087-76-8.mol
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6-chloro-3-nitroimidazo[1,2-b]pyridazine Property

Melting point:
142-145 °C
Density 
1.85±0.1 g/cm3(Predicted)
storage temp. 
under inert gas (nitrogen or Argon) at 2-8°C
pka
-1.69±0.30(Predicted)
Appearance
Light yellow to yellow Solid
InChI
InChI=1S/C6H3ClN4O2/c7-4-1-2-5-8-3-6(11(12)13)10(5)9-4/h1-3H
InChIKey
IJEZMDPWGDWYKJ-UHFFFAOYSA-N
SMILES
C12=NC=C([N+]([O-])=O)N1N=C(Cl)C=C2
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26
WGK Germany 
3
F 
10-34
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P270Do not eat, drink or smoke when using this product.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
C368243
Product name
6-Chloro-3-nitroimidazo[1,2-b]pyridazine
Packaging
100mg
Price
$75
Updated
2021/12/16
Matrix Scientific
Product number
069243
Product name
6-Chloro-3-nitroimidazo[1,2-b]pyridazine
Purity
98%
Packaging
1g
Price
$24
Updated
2021/12/16
Biosynth Carbosynth
Product number
FC140686
Product name
6-Chloro-3-nitroimidazo[1,2-b]pyridazine
Packaging
2g
Price
$63
Updated
2021/12/16
Matrix Scientific
Product number
069243
Product name
6-Chloro-3-nitroimidazo[1,2-b]pyridazine
Purity
98%
Packaging
5g
Price
$74
Updated
2021/12/16
ChemScene
Product number
CS-W003502
Product name
6-Chloro-3-nitroimidazo[1,2-b]pyridazine
Purity
99.85%
Packaging
5g
Price
$78
Updated
2021/12/16
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6-chloro-3-nitroimidazo[1,2-b]pyridazine Chemical Properties,Usage,Production

Synthesis

6775-78-6

18087-76-8

The general procedure for the synthesis of 6-chloro-3-nitroimidazo[1,2-b]pyridazine from 6-chloroimidazo[1,2-b]pyridazine was as follows: 6-chloroimidazo[1,2-b]pyridazine (4.95 g, 31.6 mmol) was dissolved in 60 mL of concentrated sulfuric acid and cooled in an ice bath. Nitric acid (9.9 mL, 158 mmol) was added slowly and dropwise under stirring conditions. The reaction mixture was stirred at 0 °C for 30 min, followed by continued stirring at room temperature for 4.5 h to ensure complete reaction. Upon completion of the reaction, the mixture was slowly poured into ice water and the resulting aqueous solution was neutralized with 50% aqueous sodium hydroxide. Subsequently, extraction was carried out with ethyl acetate (3 x 400 mL). The organic phases were combined and washed sequentially with water (2 x 400 mL) and saturated saline (400 mL). The organic layer was dried over anhydrous sodium sulfate, filtered and concentrated to afford the target product 6-chloro-3-nitroimidazo[1,2-b]pyridazine (5.7 g, 91% yield) in the form of light yellow powder.

References

[1] Patent: WO2010/33941, 2010, A1. Location in patent: Page/Page column 35
[2] Patent: CN106632353, 2017, A. Location in patent: Paragraph 0013; 0015; 0017; 0018; 0019; 0020
[3] Patent: WO2009/60197, 2009, A1. Location in patent: Page/Page column 113
[4] Chemical and Pharmaceutical Bulletin, 1996, vol. 44, # 1, p. 122 - 131
[5] Patent: US2012/65184, 2012, A1. Location in patent: Page/Page column 39

6-chloro-3-nitroimidazo[1,2-b]pyridazine Preparation Products And Raw materials

Raw materials

Preparation Products

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6-chloro-3-nitroimidazo[1,2-b]pyridazine Suppliers

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View Lastest Price from 6-chloro-3-nitroimidazo[1,2-b]pyridazine manufacturers

Shanghai Rlavie Technology Co ltd
Product
6-Chloro-3-Nitro-Imidazo[1,2-B]Pyridazin 18087-76-8
Price
US $0.00-0.00/KG
Min. Order
1g
Purity
98%minHPLC
Supply Ability
50kgs/month
Release date
2021-11-15
Dideu Industries Group Limited
Product
6-CHLORO-3-NITRO-IMIDAZO[1,2-B]PYRIDAZIN 18087-76-8
Price
US $1.10/g
Min. Order
1g
Purity
99.00%
Supply Ability
100 Tons Min
Release date
2021-11-02
Career Henan Chemical Co
Product
6-Chloro-3-nitroimidazo[1,2-b]pyridazine 18087-76-8
Price
US $1.00/g
Min. Order
1g
Purity
Min98%HPLC
Supply Ability
g/kg/ton
Release date
2020-01-09

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