ChemicalBook > CAS DataBase List > BIA 2-093

BIA 2-093

Product Name: BIA 2-093
CAS No.: 236395-14-5
Chemical Name: BIA 2-093
Synonyms: Aptiom;Exalief;Stedesa;Zebinix;Sep 0002093;BIA 2-093;APTIOM;BIA 2-093[B5435];Eslikazepine Acetate;S-Licarbazepine Acetate;EslicarbazepineAcetate>
CBNumber: CB5503197
Molecular Formula: C17H16N2O3
Formula Weight: 296.32
MOL File: 236395-14-5.mol

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BIA 2-093 Property

Melting point:: 183-185°C
Boiling point:: 427.4±55.0 °C(Predicted)
Density: 1.32
storage temp.: Sealed in dry,2-8°C
solubility: H₂O: insoluble
form: solid
pka: 13.97±0.40(Predicted)
color: white
InChIKey: QIALRBLEEWJACW-INIZCTEOSA-N

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36
WGK Germany: 3
HS Code: 2934.99.3000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: B5435
Product name: BIA 2-093
Purity: ≥98% (HPLC), solid
Packaging: 10mg
Price: $179.55
Updated: 2025/07/31

TCI Chemical

Product number: E1046
Product name: Eslicarbazepine Acetate
Purity: >98.0%(HPLC)(N)
Packaging: 200mg
Price: $194
Updated: 2025/07/31

TCI Chemical

Product number: E1046
Product name: Eslicarbazepine Acetate
Purity: >98.0%(HPLC)(N)
Packaging: 1g
Price: $677
Updated: 2025/07/31

Cayman Chemical

Product number: 23656
Product name: Eslicarbazepine Acetate
Purity: ≥95%
Packaging: 5mg
Price: $93
Updated: 2024/03/01

Cayman Chemical

Product number: 23656
Product name: Eslicarbazepine Acetate
Purity: ≥95%
Packaging: 10mg
Price: $176
Updated: 2024/03/01

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BIA 2-093 Chemical Properties,Usage,Production

Description

Although epilepsy is a neurological disorder with varying etiology and severity, the common feature is unprovoked, recurring seizures. Even when traditional AEDs, such as phenobarbital, phenytoin, carbamazepine, and valproate, control seizure activity, their effectiveness is hampered by considerable side effects and the tendency for drug-drug interactions. Designed for improved efficacy and safety, eslicarbazepine acetate is a third-generation AED that has been approved as adjunctive therapy for partial-onset seizures with or without secondary generalization. As a member of the carbamazepine family (first generation), it is the prodrug of eslicarbazepine and the active metabolite of oxcarbazepine (second generation). .

Description

Eslicarbazepine acetate is a sodium channel blocker (IC₅₀ = 138 nM in a radioligand binding assay). It inhibits sodium uptake in a dose-dependent manner in rat cortical synaptosomes at concentrations ranging from 30-300 μM. In vivo, oral and i.p. administration of eslicarbazepine acetate is protective against seizures induced by maximal electroshock (MES) in mice with ED₅₀ values of 4.7 and 6.3 mg/kg, respectively, which are well below the median toxic dose (TD₅₀) values of 358.7 and 78.6 mg/kg for oral and i.p. administration respectively. High-dose administration (30 mg/kg) of eslicarbazepine acetate prevents picrotoxin-induced seizures in rats. Low-dose administration (10 mg/kg) does not suppress picrotoxin-induced seizures, however, it reduces seizure number and duration. Formulations containing eslicarbazepine acetate have been used for the treatment of partial-onset seizures.

Chemical Properties

White to Off-White Solid

Originator

BIAL Group (Spain)

Uses

Eslicarbazepine acetate, (BIA 2-093), is a promising antiepileptic drug structurally related to Carbamazepine and Oxcarbazepine. Neuroprotective & Neuroresearch product.

Definition

ChEBI: The acetate ester, with S configuration, of licarbazepine. An anticonvulsant, it is approved for use in Europe and the United States as an adjunctive therapy for epilepsy.

brand name

Zebinix; Exalief, Stedesa

Side effects

The most common adverse events occurring with an incidence of >2% were dizziness, somnolence, nausea, diplopia, headache, vomiting, abnormal coordination, blurred vision, vertigo, and fatigue. While most of these side effects appeared to be mild to moderate, they did display a dose dependency. Although eslicarbazepine acetate is only contraindicated in patients with a known hypersensitivity to the carbamazepine family of AEDs, caution should be exercised in patients with cardiac conduction abnormalities (potential for prolongations in PR intervals), renal impairment, and in patients of Han Chinese and Thai origin since the presence of HLA-B*1502 allele in these individuals has been shown to be strongly associated with the risk of developing Stevens-Johnson syndrome. Regarding drug interactions, eslicarbazepine acetate may decrease the effectiveness of hormonal contraceptives, so alternative or additional methods of contraception should be considered.

References

[1] JAN BENES. Anticonvulsant and Sodium Channel-Blocking Properties of Novel 10,11-Dihydro-5H-dibenz[b,f]azepine-5-carboxamide Derivatives[J]. Journal of Medicinal Chemistry, 1999, 42 14: 2582-2587. DOI: 10.1021/jm980627g
[2] GERMáN SIERRA-PAREDES. Anticonvulsant effect of eslicarbazepine acetate (BIA 2-093) on seizures induced by microperfusion of picrotoxin in the hippocampus of freely moving rats[J]. Epilepsy Research, 2006, 72 2: Pages 140-146. DOI: 10.1016/j.eplepsyres.2006.07.010
[3] RAFAEL TOLEDANO . Efficacy and safety of eslicarbazepine acetate monotherapy for partial-onset seizures: Experience from a multicenter, observational study[J]. Epilepsy & Behavior, 2017, 73: Pages 173-179. DOI: 10.1016/j.yebeh.2017.02.028

BIA 2-093 Preparation Products And Raw materials

Raw materials

Preparation Products

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View Lastest Price from BIA 2-093 manufacturers

Career Henan Chemical Co

Product: Blonanserin 236395-14-5
Price: US $2.00/kg
Min. Order: 1kg
Purity: 9%
Supply Ability: 100kg
Release date: 2018-12-23

236395-14-5, BIA 2-093Related Search:

Hydrochlorothiazide Amiodarone hydrochloride Cattle encephalon glycoside ignotin Olmesartan Medoxomil Celiprolol Posaconazole KP 103 Escitalopram Eslicarbazepine

S(+)-10-acetoxy-10,11-Dihydro-10-5H-dibenz[b,f]azepine-5-carboxamide

Aptiom

BIA 2-093;APTIOM

Licarbazepine Impurity 4(Licarbazepine Acetate S-Isomer)

Sep 0002093

(S)-5-CarbaMoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl acetate

5H-Dibenz[b,f]azepine-5-carboxaMide, 10-(acetyloxy)-10,11-dihydro-, (10S)-

Acetic acid 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10(S)-yl ester

Eslicarbazepine acetate Impurity

S-Licarbazepine Acetate

(10S)-10-(Acetyloxy)-10,11-dihydro-5H-dibenz[b,f]azepine-5-carboxaMide

Eslicarbazepine Acetate BIA 2-093

(S)-(-)-10-ACETOXY-10,11-DIHYDRO-5H-DIBENZO/B,F/AZEPINE-5-CARBOXAMIDE-

Licarbazepine Acetate S-Isomer

EslicarbazepineAcetate&gt

Exalief

Stedesa

Zebinix

Eslicarbazepine acetate (racemate)

Acetic acid 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-10-yl ester

Acetic acid 5-carbamoyl-10,11-dihydro-5H-dibenzo[b,f]azepin-...

Eslicarbazepine D8 acetate (racemate)

(S)-10-Acetyloxy-10,11-dihydro-5H-Dibenz[b,f]azepine-5-carboxamide

Na channels,Beta-secretase,Eslicarbazepine,BACE,inhibit,Eslicarbazepine Acetate,Na+ channels,Sodium Channel,β-Secretase,Inhibitor

Eslikazepine Acetate

Eslicarbazepine Acetate, 10 mM in DMSO

Eslicarbazepine acetate, 98.5%~102%

BIA 2-093[B5435]

236395-14-5

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