ChemicalBook > CAS DataBase List > BIA 2-093

BIA 2-093

Product Name
BIA 2-093
CAS No.
236395-14-5
Chemical Name
BIA 2-093
Synonyms
Aptiom;Exalief;Stedesa;Zebinix;Sep 0002093;BIA 2-093;APTIOM;Eslikazepine Acetate;S-Licarbazepine Acetate;EslicarbazepineAcetate>Licarbazepine Acetate S-Isomer
CBNumber
CB5503197
Molecular Formula
C17H16N2O3
Formula Weight
296.32
MOL File
236395-14-5.mol
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BIA 2-093 Property

Melting point:
183-185°C
Boiling point:
427.4±55.0 °C(Predicted)
Density 
1.32
storage temp. 
Sealed in dry,2-8°C
solubility 
H2O: insoluble
form 
solid
pka
13.97±0.40(Predicted)
color 
white
InChIKey
QIALRBLEEWJACW-INIZCTEOSA-N
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2934.99.3000
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
B5435
Product name
BIA 2-093
Purity
≥98% (HPLC), solid
Packaging
10mg
Price
$216
Updated
2024/03/01
TCI Chemical
Product number
E1046
Product name
Eslicarbazepine Acetate
Purity
>98.0%(HPLC)(N)
Packaging
200mg
Price
$194
Updated
2024/03/01
TCI Chemical
Product number
E1046
Product name
Eslicarbazepine Acetate
Purity
>98.0%(HPLC)(N)
Packaging
1g
Price
$677
Updated
2024/03/01
Cayman Chemical
Product number
23656
Product name
Eslicarbazepine Acetate
Purity
≥95%
Packaging
5mg
Price
$93
Updated
2024/03/01
Cayman Chemical
Product number
23656
Product name
Eslicarbazepine Acetate
Purity
≥95%
Packaging
10mg
Price
$176
Updated
2024/03/01
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BIA 2-093 Chemical Properties,Usage,Production

Description

Although epilepsy is a neurological disorder with varying etiology and severity, the common feature is unprovoked, recurring seizures. Even when traditional AEDs, such as phenobarbital, phenytoin, carbamazepine, and valproate, control seizure activity, their effectiveness is hampered by considerable side effects and the tendency for drug-drug interactions. Designed for improved efficacy and safety, eslicarbazepine acetate is a third-generation AED that has been approved as adjunctive therapy for partial-onset seizures with or without secondary generalization. As a member of the carbamazepine family (first generation), it is the prodrug of eslicarbazepine and the active metabolite of oxcarbazepine (second generation). .

Description

Eslicarbazepine acetate is a sodium channel blocker (IC50 = 138 nM in a radioligand binding assay). It inhibits sodium uptake in a dose-dependent manner in rat cortical synaptosomes at concentrations ranging from 30-300 μM. In vivo, oral and i.p. administration of eslicarbazepine acetate is protective against seizures induced by maximal electroshock (MES) in mice with ED50 values of 4.7 and 6.3 mg/kg, respectively, which are well below the median toxic dose (TD50) values of 358.7 and 78.6 mg/kg for oral and i.p. administration respectively. High-dose administration (30 mg/kg) of eslicarbazepine acetate prevents picrotoxin-induced seizures in rats. Low-dose administration (10 mg/kg) does not suppress picrotoxin-induced seizures, however, it reduces seizure number and duration. Formulations containing eslicarbazepine acetate have been used for the treatment of partial-onset seizures.

Chemical Properties

White to Off-White Solid

Originator

BIAL Group (Spain)

Uses

Eslicarbazepine acetate, (BIA 2-093), is a promising antiepileptic drug structurally related to Carbamazepine and Oxcarbazepine. Neuroprotective & Neuroresearch product.

Definition

ChEBI: The acetate ester, with S configuration, of licarbazepine. An anticonvulsant, it is approved for use in Europe and the United States as an adjunctive therapy for epilepsy.

brand name

Zebinix; Exalief, Stedesa

Side effects

The most common adverse events occurring with an incidence of >2% were dizziness, somnolence, nausea, diplopia, headache, vomiting, abnormal coordination, blurred vision, vertigo, and fatigue. While most of these side effects appeared to be mild to moderate, they did display a dose dependency. Although eslicarbazepine acetate is only contraindicated in patients with a known hypersensitivity to the carbamazepine family of AEDs, caution should be exercised in patients with cardiac conduction abnormalities (potential for prolongations in PR intervals), renal impairment, and in patients of Han Chinese and Thai origin since the presence of HLA-B*1502 allele in these individuals has been shown to be strongly associated with the risk of developing Stevens-Johnson syndrome. Regarding drug interactions, eslicarbazepine acetate may decrease the effectiveness of hormonal contraceptives, so alternative or additional methods of contraception should be considered.

BIA 2-093 Preparation Products And Raw materials

Raw materials

Preparation Products

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BIA 2-093 Suppliers

Americas 1 Brazil 1 Canada 3 China 136 Czech Republic 1 Europe 1 France 2 Germany 2 India 50 Italy 1 Japan 1 Switzerland 1 The Netherlands 1 United Kingdom 4 United States 19 Global 224
LGM Pharma
Tel
1-(800)-881-8210
Fax
615-250-9817
Email
inquiries@lgmpharma.com
Country
United States
ProdList
2123
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70
MedChemexpress LLC
Tel
021-58955995
Fax
609-228-5909
Email
sales@medchemexpress.cn
Country
United States
ProdList
4861
Advantage
58
TargetMol Chemicals Inc.
Tel
+1-781-999-5354 +1-00000000000
Email
marketing@targetmol.com
Country
United States
ProdList
32165
Advantage
58
Standardpharm Co. Ltd.
Tel
86-714-3992388
Email
overseasales1@yongstandards.com
Country
United States
ProdList
14332
Advantage
58
Aladdin Scientific
Tel
+1-+1(833)-552-7181
Email
sales@aladdinsci.com
Country
United States
ProdList
57505
Advantage
58
TargetMol Chemicals Inc.
Tel
Email
support@targetmol.com
Country
United States
ProdList
38632
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58
Cayman Chemical Company
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--
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Email
cayman@caymanchem.com
Country
United States
ProdList
6213
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81
Jubilant Pharma Holdings Inc.
Tel
--
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Email
bd.api@jubl.com
Country
United States
ProdList
39
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58
Parchem Fine & Specialty Chemicals
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info@parchem.com
Country
United States
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TOPCHEM PHARMACEUTICALS LTD
Tel
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Email
Vinchem@vinchem.com
Country
United States
ProdList
140
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58
MilliporeSigma (Sigma-Aldrich Corp.)
Tel
--
Fax
--
Email
@sial.com
Country
United States
ProdList
5414
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58
Selleck Chemicals LLC
Tel
--
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Email
sales@selleckchem.com
Country
United States
ProdList
1848
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58
Genegobio Inc.
Tel
--
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Email
mark@genegobio.com
Country
United States
ProdList
195
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OChem Incorporation
Tel
--
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Email
sales@ocheminc.com
Country
United States
ProdList
6501
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60
MedChemExpress
Tel
--
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sales@medchemexpress.com
Country
United States
ProdList
6398
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Riedel-de Haen AG
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United States
ProdList
6773
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TCI America
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--
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Email
sales@tciamerica.com
Country
United States
ProdList
6909
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APAC Pharmaceutical, LLC
Tel
--
Fax
--
Email
sales@apacpharma.com
Country
United States
ProdList
6322
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38
AK Scientific, Inc.
Tel
--
Fax
--
Email
sales@aksci.com
Country
United States
ProdList
6347
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View Lastest Price from BIA 2-093 manufacturers

Career Henan Chemical Co
Product
Blonanserin 236395-14-5
Price
US $2.00/kg
Min. Order
1kg
Purity
9%
Supply Ability
100kg
Release date
2018-12-23

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