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3 5-DIFLUOROSALICYLALDEHYDE 97

Product Name
3 5-DIFLUOROSALICYLALDEHYDE 97
CAS No.
63954-77-8
Chemical Name
3 5-DIFLUOROSALICYLALDEHYDE 97
Synonyms
3,5-Difluoro-2-hydrox;3,5-Difluorosalicaldehyde;3 5-Difluorosalicyaldehyde;3,5-Difluorosalicylaldehyde 97%;3 5-DIFLUOROSALICYLALDEHYDE 97;3,5-difluoro-2-hydroxybenzaldehde;Benzaldehyde, 3,5-difluoro-2-hydroxy-;3,5-Difluoro-2-hydroxybenzaldehyde98%;3,5-Difluoro-2-hydroxybenzaldehyde 98%;3,5-Difluorosalicylaldehyde, 2,4-Difluoro-6-formylphenol
CBNumber
CB5504260
Molecular Formula
C7H4F2O2
Formula Weight
158.1
MOL File
63954-77-8.mol
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3 5-DIFLUOROSALICYLALDEHYDE 97 Property

Melting point:
87-91 °C (lit.)
Boiling point:
181.9±35.0 °C(Predicted)
Density 
1.464±0.06 g/cm3(Predicted)
storage temp. 
Keep in dark place,Sealed in dry,Room Temperature
form 
solid
pka
6.94±0.23(Predicted)
color 
White to off-white
InChI
InChI=1S/C7H4F2O2/c8-5-1-4(3-10)7(11)6(9)2-5/h1-3,11H
InChIKey
QGSAZWCEHUYVMW-UHFFFAOYSA-N
SMILES
C(=O)C1=CC(F)=CC(F)=C1O
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Safety

Hazard Codes 
Xi
Risk Statements 
36/37/38
Safety Statements 
26-36
WGK Germany 
3
HS Code 
2912490090
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

TRC
Product number
D445913
Product name
3,5-Difluoro-2-hydroxybenzaldehyde
Packaging
50mg
Price
$45
Updated
2021/12/16
Apolloscientific
Product number
PC1112
Product name
3,5-Difluoro-2-hydroxybenzaldehyde
Purity
98%
Packaging
1g
Price
$73
Updated
2021/12/16
AK Scientific
Product number
9799AB
Product name
3,5-Difluoro-2-hydroxybenzaldehyde
Packaging
1g
Price
$79
Updated
2021/12/16
SynQuest Laboratories
Product number
2615-3-31
Product name
3,5-Difluoro-2-hydroxybenzaldehyde
Purity
98%
Packaging
1g
Price
$80
Updated
2021/12/16
Apolloscientific
Product number
PC1112
Product name
3,5-Difluoro-2-hydroxybenzaldehyde
Purity
98%
Packaging
5g
Price
$247
Updated
2021/12/16
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3 5-DIFLUOROSALICYLALDEHYDE 97 Chemical Properties,Usage,Production

Uses

3,5-Difluorosalicylaldehyde may be used in the synthesis of Ni[CpFe(η5-C5H4)-C(O)CH=C(CH3)N-o-C6H4N=CH-(2-O,3,5-F2-C6H2)] (Cp = cyclopentyl) and Zn(salphenazine) complex.

General Description

3,5-Difluorosalicylaldehyde has been synthesized by employing 2,4-difluorophenol as a starting reagent.

Synthesis

367-27-1

68-12-2

63954-77-8

Phosphoryl chloride (12 g, 77 mmol) was slowly added dropwise to anhydrous N,N-dimethylformamide (8.4 g, 0.12 mol) at 0 °C and under nitrogen protection while maintaining stirring. After the dropwise addition, the reaction mixture was continued to be stirred at this temperature for 30 min. Subsequently, a solution of N,N-dimethylformamide (50 mL) of 2,4-difluorophenol (5.0 g, 39 mmol) was slowly added dropwise to the above mixture. After completion of the dropwise addition, the reaction mixture was transferred to room temperature conditions with continuous stirring for 5 hours. Upon completion of the reaction, the reaction was carefully quenched with water and extracted with ethyl acetate (3 x 150 mL). The organic phases were combined, washed sequentially with water and saturated brine, dried over anhydrous sodium sulfate, and finally concentrated under reduced pressure to afford the target product 3,5-difluoro-2-hydroxybenzaldehyde (5.5 g, 90% yield) as a yellow oil.

References

[1] Patent: WO2015/66371, 2015, A1. Location in patent: Paragraph 00326-00327

3 5-DIFLUOROSALICYLALDEHYDE 97 Preparation Products And Raw materials

Raw materials

Preparation Products

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3 5-DIFLUOROSALICYLALDEHYDE 97 Suppliers

China 109 India 1 Switzerland 1 United Kingdom 1 United States 6 Global 118
SIGMA-RBI
Tel
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Fax
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Country
Switzerland
ProdList
6896
Advantage
91
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View Lastest Price from 3 5-DIFLUOROSALICYLALDEHYDE 97 manufacturers

Shaanxi Dideu Medichem Co. Ltd
Product
3,5-Difluorosalicylaldehyde 63954-77-8
Price
US $0.10-10.00/KG
Min. Order
1KG
Purity
99%
Supply Ability
200TONS
Release date
2025-08-18
Career Henan Chemical Co
Product
3 5-DIFLUOROSALICYLALDEHYDE 97 63954-77-8
Price
US $1.00/KG
Min. Order
1KG
Purity
98%
Supply Ability
1kg,5kg,100kg
Release date
2019-07-04

63954-77-8, 3 5-DIFLUOROSALICYLALDEHYDE 97Related Search:

3,5-DIFLUORO-2-METHOXYBENZALDEHYDE 3',5'-DIFLUORO-2'-HYDROXYACETOPHENONE 3,5-DIFLUORO-2-METHOXYBENZOIC ACID 5,7-DIFLUORO-BENZOFURAN-3-ONE 3,5-DIFLUORO-2-METHOXYBENZAMIDE 3,5-DIFLUORO-2-METHOXYBENZOYL CHLORIDE 2-ETHOXY-3,5-DIFLUOROBENZOIC ACID 2-ETHOXY-3,5-DIFLUOROBENZALDEHYDE 3,4,5,6-TETRAFLUORO-2-HYDROXYBENZOIC ACID 2-ETHOXY-3,5-DIFLUOROBENZOYL CHLORIDE 3 5-DIFLUOROSALICYLALDEHYDE 97 3,5-DIFLUORO-2-HYDROXY-BENZOIC ACID 2-ETHOXY-3,5-DIFLUOROBENZAMIDE BUTTPARK 35\07-35 methyl 3,5-difluoro-2-methoxybenzoate RARECHEM AL BI 1422 5,6,7,8-TETRAFLUORO-2-METHYL-4-OXO-4H-CHROMENE-3-CARBOXYLIC ACID ETHYL ESTER 3,5-DIFLUORO-2-HYDROXY-BENZOIC ACID METHYL ESTER

  • 3,5-Difluoro-2-hydrox
  • 3 5-DIFLUOROSALICYLALDEHYDE 97
  • 3,5-Difluoro-2-hydroxybenzaldehyde 98%
  • 3,5-difluoro-2-hydroxybenzaldehde
  • 3,5-Difluorosalicaldehyde
  • 3,5-Difluorosalicylaldehyde, 2,4-Difluoro-6-formylphenol
  • 3,5-Difluorosalicylaldehyde 97%
  • 3,5-Difluoro-2-hydroxybenzaldehyde98%
  • Benzaldehyde, 3,5-difluoro-2-hydroxy-
  • 3 5-Difluorosalicyaldehyde
  • 63954-77-8
  • F2C6H2OHCHO
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