AHSG
Description Source Background- Product Name
- AHSG
- Chemical Name
- AHSG
- Synonyms
- AHS;wa2;HSGA;AHSG;A2HS;Errb;wa-2;Errb1;PRO2743;AI552599
- CBNumber
- CB55177564
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb528240
- Product name
- AHSG
- Packaging
- 10μg
- Price
- $290.7
- Updated
- 2021/12/16
AHSG Chemical Properties,Usage,Production
Description
The human Alpha-2-HS-Glycoprotein containing 349 a.a was purified from the human plasma.
The total molecular mass is 37.3kDa (calculated without glycosylation).
Source
Purified from the human plasma
Background
Fetuin is a liver-produced negative acute phase protein composed of two subunits, the A and B chains.
Fetuin homologs have been identified in several species including rat, sheep, pig, rabbit, guinea pig, cattle, mouse and human. Multiple physiological roles for these homologs have been suggested, including ability to bind to hydroxyapatite crystals and to specifically inhibit the tyrosine kinase (TK) activity of the insulin receptor (IR).
Fetuin-A (alpha2-Heremans-Schmid glycoprotein; AHSG) is an important circulating inhibitor of calcification in vivo, and is downregulated during the acute-phase response.
Sera from patients on long-term dialysis with low AHSG concentrations showed impaired ex-vivo capacity to inhibit CaxPO4 precipitation.
Fetuin may influence the resolution of inflammation by modulating the phagocytosis of apoptotic cells by macrophages.
ASHG blocks TGF-beta-dependent signaling in osteoblastic cells, and mice lacking ASHG display growth plate defects, increased bone formation with age, and enhanced cytokine-dependent osteogenesis.
AHSG Preparation Products And Raw materials
Raw materials
Preparation Products
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