Endovion

Product Name: Endovion
CAS No.: 265646-85-3
Chemical Name: Endovion
Synonyms: NS3728;Endovion;Endovion (NS 3728);NS3728 >=98% (HPLC);Endovion, 10 mM in DMSO;Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
CBNumber: CB55419734
Molecular Formula: C16H9BrF6N6O
Formula Weight: 495.18
MOL File: 265646-85-3.mol

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Endovion Property

Density: 1.791±0.06 g/cm3(Predicted)
storage temp.: Store at -20°C
solubility: Soluble to 100 mM in DMSO and to 50 mM in ethanol
pka: 3.95±0.10(Predicted)
form: Solid
color: White to off-white
Water Solubility: Water : < 0.1 mg/mL (insoluble)
InChI: 1S/C16H9BrF6N6O/c17-9-1-2-11(13-26-28-29-27-13)12(6-9)25-14(30)24-10-4-7(15(18,19)20)3-8(5-10)16(21,22)23/h1-6H,(H2,24,25,30)(H,26,27,28,29)
InChIKey: OQRAKHDEGGGWQO-UHFFFAOYSA-N
SMILES: FC(F)(F)c1cc(cc(c1)C(F)(F)F)NC(=O)Nc2c(ccc(c2)Br)c3n[nH]nn3

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Safety

WGK Germany: WGK 3
Storage Class: 11 - Combustible Solids

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

Precautionary statements

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

P337+P313IF eye irritation persists: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: SML1964
Product name: NS3728
Purity: ≥98% (HPLC)
Packaging: 5 mg
Price: $91.8
Updated: 2025/07/31

Tocris

Product number: 6973
Product name: NS3728
Purity: ≥98%(HPLC)
Packaging: 50
Price: $669
Updated: 2021/12/16

TRC

Product number: N926063
Product name: NS3728
Packaging: 5mg
Price: $250
Updated: 2021/12/16

ChemScene

Product number: CS-0026942
Product name: Endovion
Purity: 99.27%
Packaging: 25mg
Price: $320
Updated: 2021/12/16

ChemScene

Product number: CS-0026942
Product name: Endovion
Purity: 99.27%
Packaging: 5mg
Price: $90
Updated: 2021/12/16

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Endovion Chemical Properties,Usage,Production

Biological Activity

Endovion (NS3728) is an anion channel inhibitor (eg chloride channel) and a specific VRAC/VSOAC blocker.

in vitro

Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, eg, expression of p21 ^Waf1/Cip1 , Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells.
Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines.

Western Blot Analysis

< td class="col1"> Result:

Cell Line:	Wild -type, resistant, and transiently transfected A2780 cells.
Concentration:	10-100 μM. < /td>
Incubation Time:	18 or 4.5 h.
Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells. Resulted i n an increased LRRC8A protein expression. Significantly reduced p53 and ^p21Waf1/Cip1 protein level in A2780WT cells.

Cell Proliferation Assay

Cell Line:	Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines.
Concentration:	10 μM.
Incubation Time:	24 h.
Result:	Resulted in the most pronounced inhibition in all cell lines with 77 ± 26 % in Capan-1, 67 ± 9 % in AsPC-1, and 54 ± 8 % in BxPC-3 cells at +67 mV.

target

Chloride channel, VRAC/VSOAC.
ANO1.

storage

Store at -20°C

Endovion Preparation Products And Raw materials

Raw materials

Preparation Products

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Endovion Suppliers

China 46 United States 3 Global 49

Nanjing Chemlin Chemical Co., Ltd

Tel: 025-83697070 13913916777;
Fax: +86-25-83453306
Email: info@chemlin.com.cn
Country: China
ProdList: 15724
Advantage: 64

Shanghai Raise Chemical Technology Co.,Ltd

Tel: 15026594951
Fax: 0556-5030632
Email: rs@raise-chem.com
Country: China
ProdList: 4621
Advantage: 55

Hangzhou J&H Chemical Co., Ltd.

Tel: 0571-87396432
Fax: 0571-87396431
Email: sales@jhechem.com
Country: China
ProdList: 14917
Advantage: 59

Shanghai Lollane Biological Technology Co.,Ltd.

Tel: 021-52996696，15000506266 15000506266
Fax: +86-21-52996696
Country: China
ProdList: 4800
Advantage: 55

Shanghai EFE Biological Technology Co., Ltd.

Tel: 021-65675885 18964387627
Fax: 021-65675885
Email: info@efebio.com
Country: China
ProdList: 9803
Advantage: 58

Shanghai YuanYe Biotechnology Co., Ltd.

Tel: 021-61312847; 18021002903
Fax: QQ:3008007432
Email: 3008007409@qq.com
Country: China
ProdList: 71826
Advantage: 60

ShangHai Biochempartner Co.,Ltd

Tel: 177-54423994 17754423994
Fax: QQ:2853530913
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Country: China
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Shanghai Rechem science Co., Ltd.

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Shanghai Chaolan Chemical Technology Center

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Email: Sales@ATKchemical.com
Country: China
ProdList: 9543
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Shanghai Yu Ben Biotechnology Co., Ltd.

Tel: 021-61350663 15502154572
Fax: -
Email: 1639466865@qq.com
Country: China
ProdList: 499
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265646-85-3, EndovionRelated Search:

Endovion

NS3728

Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-

NS3728 >=98% (HPLC)

1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea

Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728

Endovion, 10 mM in DMSO

Endovion (NS 3728)

265646-85-3

CHBrFNO

C16H9BrF6N6O