Endovion
- Product Name
- Endovion
- CAS No.
- 265646-85-3
- Chemical Name
- Endovion
- Synonyms
- NS3728;Endovion;NS3728 >=98% (HPLC);Cl? Channels,Inhibitor,NS 3728,Endovion,Chloride Channel,inhibit,NS-3728;1-(3,5-Bis(trifluoromethyl)phenyl)-3-(4-bromo-2-(2H-tetrazol-5-yl)phenyl)urea;Urea, N-[3,5-bis(trifluoromethyl)phenyl]-N'-[4-bromo-2-(2H-tetrazol-5-yl)phenyl]-
- CBNumber
- CB55419734
- Molecular Formula
- C16H9BrF6N6O
- Formula Weight
- 495.18
- MOL File
- 265646-85-3.mol
Endovion Property
- Density
- 1.791±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- Soluble to 100 mM in DMSO and to 50 mM in ethanol
- pka
- 3.95±0.10(Predicted)
- form
- Solid
- color
- White to off-white
- Water Solubility
- Water : < 0.1 mg/mL (insoluble)
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H315Causes skin irritation
H319Causes serious eye irritation
- Precautionary statements
-
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P332+P313IF SKIN irritation occurs: Get medical advice/attention.
P337+P313IF eye irritation persists: Get medical advice/attention.
N-Bromosuccinimide Price
- Product number
- 6973
- Product name
- NS3728
- Purity
- ≥98%(HPLC)
- Packaging
- 50
- Price
- $669
- Updated
- 2021/12/16
- Product number
- N926063
- Product name
- NS3728
- Packaging
- 5mg
- Price
- $250
- Updated
- 2021/12/16
- Product number
- CS-0026942
- Product name
- Endovion
- Purity
- 99.27%
- Packaging
- 25mg
- Price
- $320
- Updated
- 2021/12/16
- Product number
- CS-0026942
- Product name
- Endovion
- Purity
- 99.27%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- CS-0026942
- Product name
- Endovion
- Purity
- 99.27%
- Packaging
- 50mg
- Price
- $580
- Updated
- 2021/12/16
Endovion Chemical Properties,Usage,Production
Biological Activity
Endovion (NS3728) is an anion channel inhibitor (eg chloride channel) and a specific VRAC/VSOAC blocker.
in vitro
Endovion (NS3728, 10-100 μM) reduces TNFα-induced apoptosis and increases p53-protein level as well as downstream signaling, eg, expression of p21 Waf1/Cip1 , Bax, Noxa, MDM2, and activation of Caspase-9/-3 in Cisplatin-sensitive cells.
Endovion (NS3728, 10 μM) inhibits cell proliferation in Capan-1, AsPC-1 and BxPC-3 cell lines.
Western Blot Analysis
| Cell Line: | Wild -type, resistant, and transiently transfected A2780 cells. |
| Concentration: | 10-100 μM. < /td> |
| Incubation Time: | 18 or 4.5 h. |
| Reduced the maximal taurine rate constant more than 90% compared with the untreated control cells. Resulted i n an increased LRRC8A protein expression. Significantly reduced p53 and p21Waf1/Cip1 protein level in A2780WT cells. |
Cell Proliferation Assay
| Cell Line: | Capan-1, AsPC-1, BxPC-3 and H6c7 cell lines. |
| Concentration: | 10 μM. |
| Incubation Time: | 24 h. |
| Result: | Resulted in the most pronounced inhibition in all cell lines with 77 ± 26 % in Capan-1, 67 ± 9 % in AsPC-1, and 54 ± 8 % in BxPC-3 cells at +67 mV. |
target
Chloride channel, VRAC/VSOAC.
ANO1.
storage
Store at -20°C
Endovion Preparation Products And Raw materials
Raw materials
Preparation Products
Endovion Suppliers
- Tel
- +1-781-999-5354 +1-00000000000
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- Country
- United States
- ProdList
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- United States
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