N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide

Product Name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
CAS No.: 143655-58-7
Chemical Name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Synonyms: Exatecan Intermediate 6;N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide;N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide - [F82918];N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide;N-(3-Fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)acetamide;N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrah ydronaphthalen-1-yl)acetamide;Acetamide, N-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)-
CBNumber: CB55431451
Molecular Formula: C13H14FNO2
Formula Weight: 235.25
MOL File: 143655-58-7.mol

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N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Property

Boiling point:: 443.9±45.0 °C(Predicted)
Density: 1.262±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 13.73±0.20(Predicted)
form: Solid
color: Off-white to light brown
InChI: InChI=1S/C13H14FNO2/c1-7-9-4-3-5-12(17)13(9)11(6-10(7)14)15-8(2)16/h6H,3-5H2,1-2H3,(H,15,16)
InChIKey: PSNRFAKPOCIEDV-UHFFFAOYSA-N
SMILES: C(NC1=C2C(CCCC2=O)=C(C)C(F)=C1)(=O)C

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Hazard and Precautionary Statements (GHS)

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N-Bromosuccinimide Price

AK Scientific

Product number: 3141DA
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide
Packaging: 250mg
Price: $2085
Updated: 2021/12/16

A2B

Product number: AY07154
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Purity: 98%
Packaging: 5g
Price: $2348
Updated: 2021/12/16

A2B

Product number: AY07154
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Purity: 98%
Packaging: 100mg
Price: $271
Updated: 2021/12/16

A2B

Product number: AY07154
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Purity: 98%
Packaging: 250mg
Price: $425
Updated: 2021/12/16

A2B

Product number: AY07154
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Purity: 98%
Packaging: 1g
Price: $810
Updated: 2021/12/16

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N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Chemical Properties,Usage,Production

Uses

Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).

IC 50

Camptothecins

References

[1] Zhang, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998 A. 2020-07-31.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

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N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Suppliers

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143655-58-7, N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamideRelated Search:

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrah ydronaphthalen-1-yl)acetamide

N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide

Acetamide, N-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)-

Exatecan Intermediate 6

N-(3-Fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)acetamide

N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide - [F82918]

143655-58-7