N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide

Product Name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
CAS No.: 143655-58-7
Chemical Name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Synonyms: Exatecan Intermediate 6;N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide;N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide - [F82918];N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide;N-(3-Fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)acetamide;N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrah ydronaphthalen-1-yl)acetamide;Acetamide, N-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)-
CBNumber: CB55431451
Molecular Formula: C13H14FNO2
Formula Weight: 235.25
MOL File: 143655-58-7.mol

More

Less

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Property

Boiling point:: 443.9±45.0 °C(Predicted)
Density: 1.262±0.06 g/cm3(Predicted)
storage temp.: Storage temp. 2-8°C
pka: 13.73±0.20(Predicted)
form: Solid
color: Off-white to light brown
InChI: InChI=1S/C13H14FNO2/c1-7-9-4-3-5-12(17)13(9)11(6-10(7)14)15-8(2)16/h6H,3-5H2,1-2H3,(H,15,16)
InChIKey: PSNRFAKPOCIEDV-UHFFFAOYSA-N
SMILES: C(NC1=C2C(CCCC2=O)=C(C)C(F)=C1)(=O)C

More

Less

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

More

Less

N-Bromosuccinimide Price

AK Scientific

Product number: 3141DA
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydronaphthalen-1-yl)acetamide
Packaging: 250mg
Price: $2085
Updated: 2021/12/16

A2B

Product number: AY07154
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Purity: 98%
Packaging: 5g
Price: $2348
Updated: 2021/12/16

A2B

Product number: AY07154
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Purity: 98%
Packaging: 100mg
Price: $271
Updated: 2021/12/16

A2B

Product number: AY07154
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Purity: 98%
Packaging: 250mg
Price: $425
Updated: 2021/12/16

A2B

Product number: AY07154
Product name: N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide
Purity: 98%
Packaging: 1g
Price: $810
Updated: 2021/12/16

More

Less

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Chemical Properties,Usage,Production

Uses

Exatecan Intermediate 6 is the intermediate of Exatecan (HY-13631) And Exatecan (DX-8951) is a DNA topoisomerase I inhibitor with an IC50 value of 2.2 μM (0.975 μg/mL) that can be used in cancer research. Exatecan Intermediate 6 can be used to synthesize Antibody-Drug Conjugates (ADCs).

IC 50

Camptothecins

References

[1] Zhang, et al. Intermediate for synthesizing camptothecin derivatives using exatecan mesylate and its preparation method and application. China, CN111470998 A. 2020-07-31.
[2] Mitsui I, et al. A new water-soluble camptothecin derivative, DX-8951f, exhibits potent antitumor activity against human tumors in vitro and in vivo. Jpn J Cancer Res. 1995 Aug;86(8):776-82. DOI:10.1111/j.1349-7006.1995.tb02468.x

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Preparation Products And Raw materials

Raw materials

Preparation Products

More

Less

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide Suppliers

China 68 India 1 United States 2 Global 71

Suzhou Zehou Biotechnology Co. , Ltd.

Tel: 0512-68716880 19984816880
Fax: 18075373931
Email: sales@growingchem.com
Country: China
ProdList: 217
Advantage: 64

Anqing Runke Biomedical Technology Co., Ltd.

Tel: 0512-68716880 19984816880
Fax: 0556-5282330
Email: sales@growingchem.com
Country: China
ProdList: 307
Advantage: 58

Nantong Nuotai Biomedical Technology Co., Ltd.

Tel: 0513-82206272 17706270880
Email: 2057095228@qq.com
Country: China
ProdList: 204
Advantage: 58

Shanghai Xinlitai Pharmaceutical Co. , Ltd.

Tel: 18616665298
Email: wenjie.li@bocimed.com
Country: China
ProdList: 234
Advantage: 58

YJ Pharma

Tel: 13962794339
Email: 3686954964@qq.com
Country: China
ProdList: 282
Advantage: 58

Beijing Ouhe Technology Co., Ltd

Tel: 13552068683 13522913783
Fax: +86-10-82967029
Email: 2355560935@qq.com
Country: China
ProdList: 11780
Advantage: 60

NOTA Chemical (Shanghai) Co.,Ltd

Tel: 021-50189163
Fax: 021-51687927
Email: sales@notachem.com
Country: China
ProdList: 211
Advantage: 64

QINGDAO CARELONGPHARMATECH CO.,LTD

Tel: 053288191853 13061484198
Fax: +86-532-88191853
Email: sales@carelongchem.com
Country: China
ProdList: 451
Advantage: 57

Bide Pharmatech Ltd.

Tel: 400-400-164-7117 18317119277
Fax: +86-21-61629029
Email: product02@bidepharm.com
Country: China
ProdList: 39999
Advantage: 60

Suzhou Lakestar Pharmatech Co., Ltd.

Tel: 0512-63970158-603 18018108880
Fax: 0512-63971078
Email: info@lakestarpharma.com
Country: China
ProdList: 403
Advantage: 59

143655-58-7, N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamideRelated Search:

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrahydro-1-naphthyl)acetamide

N-(3-Fluoro-4-methyl-8-oxo-5,6,7,8-tetrah ydronaphthalen-1-yl)acetamide

N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide

Acetamide, N-(3-fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)-

Exatecan Intermediate 6

N-(3-Fluoro-5,6,7,8-tetrahydro-4-methyl-8-oxo-1-naphthalenyl)acetamide

N-(7-fluoro-8-methyl-4-oxo-tetralin-5-yl)acetamide - [F82918]

143655-58-7