D-Phenylalanine, N-benzoyl-L-tryptophyl-, methyl ester
- Product Name
- D-Phenylalanine, N-benzoyl-L-tryptophyl-, methyl ester
- CAS No.
- 1435265-06-7
- Chemical Name
- D-Phenylalanine, N-benzoyl-L-tryptophyl-, methyl ester
- Synonyms
- HCH6-1;HCH6-1, 10 mM in DMSO;Methyl benzoyl-L-tryptophyl-D-phenylalaninate;Methyl N-benzoyl-L-tryptophyl-D-phenylalaninate;D-Phenylalanine, N-benzoyl-L-tryptophyl-, methyl ester;inhibit,inflammatory,FPR1,HCH6-1,cell infiltration,HCH6 1,antagonist,pulmonary,acute lung injury,lung diseases,ALI,Inhibitor,HCH61,HCH-6-1
- CBNumber
- CB55511388
- Molecular Formula
- C28H27N3O4
- Formula Weight
- 469.53
- MOL File
- 1435265-06-7.mol
D-Phenylalanine, N-benzoyl-L-tryptophyl-, methyl ester Property
- Boiling point:
- 790.8±60.0 °C(Predicted)
- Density
- 1.259±0.06 g/cm3(Predicted)
- storage temp.
- Store at -20°C
- solubility
- DMSO: 250 mg/mL (532.45 mM)
- form
- Solid
- pka
- 13.25±0.46(Predicted)
- color
- White to off-white
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- 020433
- Product name
- HCH6-1
- Packaging
- 001
- Price
- $600
- Updated
- 2021/12/16
- Product number
- 020433
- Product name
- HCH6-1
- Packaging
- 006
- Price
- $1000
- Updated
- 2021/12/16
- Product number
- 020433
- Product name
- HCH6-1
- Packaging
- 007
- Price
- $2000
- Updated
- 2021/12/16
D-Phenylalanine, N-benzoyl-L-tryptophyl-, methyl ester Chemical Properties,Usage,Production
Uses
HCH6-1 is a selective competitive antagonist of formyl peptide receptor 1 (FPR1) and has protective effects against acute lung injury (ALI).
in vivo
HCH6-1 (intraperitoneal injection; 50 mg/kg; 1 h before LPS spray or 30 min after LPS spray) alone does not induce airspace inflammation. HCH6-1 pretreatment reduces inflammatory cell infiltration and distortion of pulmonary architecture in the presence of LPS. HCH6-1 posttreatment shows inhibitory effects on neutrophil accumulation and lung damage in LPS-induced ALI mice[1].
| Animal Model: | C57BL/6 mice (20-25 g, 7-8 weeks old)[1] |
| Dosage: | 50 mg/kg |
| Administration: | Intraperitoneal injection; 50 mg/kg; 1 h before LPS spray or 30 min after LPS spray |
| Result: | Ameliorated ALI in LPS-induced mice.HCH6-1-mediated decreasing of neutrophil recruitment serves as a protective mechanism in ALI mice. |
D-Phenylalanine, N-benzoyl-L-tryptophyl-, methyl ester Preparation Products And Raw materials
Raw materials
Preparation Products
D-Phenylalanine, N-benzoyl-L-tryptophyl-, methyl ester Suppliers
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