SRS16-86
- Product Name
- SRS16-86
- CAS No.
- 1793052-96-6
- Chemical Name
- SRS16-86
- Synonyms
- SRS16-86;SRS16-86, 10 mM in DMSO;(Z)-tert-Butyl 4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate;Benzoic acid, 3-[(Z)-(5-pyrimidinylmethylene)amino]-4-(tricyclo[3.3.1.13,7]dec-1-ylamino)-, 1,1-dimethylethyl ester;IRI,SRS16-86,Inhibitor,ferrostatin,SRS-16-86,ischemia-reperfusion injury,SCI,spinal cord injury,Ferroptosis,SRS1686,inhibit,SRS16 86
- CBNumber
- CB55540799
- Molecular Formula
- C26H32N4O2
- Formula Weight
- 432.56
- MOL File
- 1793052-96-6.mol
SRS16-86 Property
- Boiling point:
- 614.9±55.0 °C(Predicted)
- Density
- 1.27±0.1 g/cm3(Predicted)
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (>25 mg/ml)
- form
- solid
- pka
- 5.58±0.20(Predicted)
- color
- Yellow
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 1 month.
N-Bromosuccinimide Price
- Product number
- 26752
- Product name
- SRS16-86
- Packaging
- 1mg
- Price
- $106
- Updated
- 2024/03/01
- Product number
- 26752
- Product name
- SRS16-86
- Packaging
- 5mg
- Price
- $359
- Updated
- 2024/03/01
- Product number
- 26752
- Product name
- SRS16-86
- Packaging
- 500μg
- Price
- $62
- Updated
- 2024/03/01
- Product number
- A1490492
- Product name
- (Z)-tert-Butyl4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate
- Purity
- 98+%
- Packaging
- 250mg
- Price
- $422
- Updated
- 2021/12/16
- Product number
- A1490492
- Product name
- (Z)-tert-Butyl4-(adamantan-1-ylamino)-3-((pyrimidin-5-ylmethylene)amino)benzoate
- Purity
- 98+%
- Packaging
- 25mg
- Price
- $118
- Updated
- 2021/12/16
SRS16-86 Chemical Properties,Usage,Production
Description
SRS16-86 (1793052-96-6) is a third generation ferrostatin derivative with greater metabolic and plasma stability for in vivo studies. It protected mice in a renal severe ischemia-reperfusion injury model via inhibition of ferroptosis.1 SRS16-86 enhanced functional recovery after spinal cord injury in a rat model via upregulation of GPX4, GSH, and xCT as well as downregulation of lipid peroxidation marker 4-hydroxynonenal.2
Definition
ChEBI: SRS16-86 is an ethyl ester resulting from the formal condensation of the carboxy group of 4-[(adamantan-1-yl)amino]-3-{(Z)-[(pyrimidin-5-yl)methylidene]amino}benzoic acid with tert-butanol. It is an inhibitor of ferroptosis induced by erastin in HT-1080 and NIH3T3 cells when used at a concentration of 1 muM. It has a role as a ferroptosis inhibitor. It is a tert-butyl ester, a member of adamantanes, a member of pyrimidines, a substituted aniline, a secondary amino compound and an imine.
References
Linkermann et al. (2014), Synchronized renal tubular cell death involves ferroptosis; Proc. Natl. Acad. Sci. USA. 111 16841 Zhang et al. (2019), Ferroptosis inhibitor SRS 16-86 attenuates ferroptosis and promotes functional recovery in contusion spinal cord injury; Brain Res. 1706 48
SRS16-86 Preparation Products And Raw materials
Raw materials
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