CARD11 antibody
Source Reactivity Background References- Product Name
- CARD11 antibody
- Chemical Name
- CARD11 antibody
- Synonyms
- CARD11 antibody;Rabbit Polyclonal CARD11 Antibody
- CBNumber
- CB55612041
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb100334
- Product name
- CARD11 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb18487
- Product name
- CARD11 antibody
- Purity
- Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide.
- Packaging
- 100μg
- Price
- $499.8
- Updated
- 2021/12/16
- Product number
- orb100334
- Product name
- CARD11 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
CARD11 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat
Background
CARD11/Carma1/Bimp3 belongs to the MAGUK family that typically function as molecular scaffolds in the assembly of multiprotein complexes. MAGUK family members contain an SH3 domain, a PDZ domain and a GuK domain homologous to guanylate kinase. In addition, CARD11 contains an amino-terminal CARD domain. This domain plays an important role in forming interactions with a number of proteins containing CARD domains that are involved in regulating apoptosis and NF-κB activation. CARD11 is predominately expressed in lymphocytes and associates with the CARD domain of Bcl10. When overexpressed, CARD11 leads to the phosphorylation of Bcl10 and activation of NF-κB. CARD11 is constitutively associated with lipid rafts and is thought to function by recruiting Bcl10 and MALT1 and triggering the phosphorylation of IKKs. Several studies using the genetic disruption of CARD11 or dominant-negative mutations have demonstrated that it plays a critical role in NF-κB activation and lymphocyte signaling.
References
[1] Bertin, J. et al. (2001) J. Biol. Chem. 276, 11877–11882.
[2] Gaide, O. et al. (2001) FEBS Lett. 496, 121-127.
[3] Stilo, R. et al. (2004) J. Biol. Chem. 279, 34323-34331.
[4] Wang, D. et al. (2002) Nat. Immunol. 3, 830-835.
[5] Jun, J.E. et al. (2003) Immunity 18, 751-762.
[6] Hara, H. et al. (2003) Immunity 18, 763-775.
[7] Gaide, O. et al. (2002) Nat. Immunol. 3, 836-843.
CARD11 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
CARD11 antibody Suppliers
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