PTBP2 antibody
Source Reactivity Background References- Product Name
- PTBP2 antibody
- Chemical Name
- PTBP2 antibody
- Synonyms
- PTBP2 antibody
- CBNumber
- CB55676991
- Formula Weight
- 0
- MOL File
- Mol file
N-Bromosuccinimide Price
- Product number
- orb158222
- Product name
- PTBP2 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 100μg
- Price
- $421.6
- Updated
- 2021/12/16
- Product number
- orb158222
- Product name
- PTBP2 antibody
- Purity
- Affinity purified by Protein A
- Packaging
- 200μg
- Price
- $673.2
- Updated
- 2021/12/16
PTBP2 antibody Chemical Properties,Usage,Production
Source
Rabbit
Reactivity
Human;Mouse;Rat;Monkey
Background
PTBP1 and PTBP2 are highly related pre-mRNA binding proteins that silence the splicing of alternative exons. While PTBP1 is widely expressed, PTBP2, also known as neural PTB or nPTB, is expressed in post-mitotic neurons. In other cell types, PTBP2 transcripts are alternatively spliced by PTBP1, which leads to nonsense-mediated decay. PTBP1 and 2 bind to similar regions across the transcriptome, but PTBP1 has a stronger repressive property likely due to cofactors such as Raver1 and Matrin3. Overexpression of PTBPs in various cancers has been observed, leading to alternative splicing of key proteins in oncogenic pathways.
References
[1] Amir-Ahmady, B. et al. (2005) RNA 11, 699-716.
[2] Oberstrass, F.C. et al. (2005) Science 309, 2054-7.
[3] Boutz, P.L. et al. (2007) Genes Dev 21, 1636-52.
[4] Keppetipola, N.M. et al. (2016) RNA 22, 1172-80.
[5] Vuong, J.K. et al. (2016) Cell Rep 17, 2766-2775.
[6] Minami, K. et al. (2017) Oncotarget 8, 33064-33077.
[7] Wang, Z.N. et al. (2017) Oncotarget 8, 36185-36202.
[8] Uemura, Y. et al. (2017) Genes Cells 22, 785-798.
[9] Bielli, P. et al. (2018) Clin Cancer Res 24, 5422-5432.
PTBP2 antibody Preparation Products And Raw materials
Raw materials
Preparation Products
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