Ubiquitin (P4D1) Mouse mAb
Source Reactivity Background References- Product Name
- Ubiquitin (P4D1) Mouse mAb
- Chemical Name
- Ubiquitin (P4D1) Mouse mAb
- Synonyms
- Ubiquitin (P4D1) Mouse mAb
- CBNumber
- CB55703448
- Formula Weight
- 0
- MOL File
- Mol file
Ubiquitin (P4D1) Mouse mAb Chemical Properties,Usage,Production
Source
Mouse
Reactivity
All
Background
Ubiquitin is a conserved polypeptide unit that plays an important role in the ubiquitin-proteasome pathway. Ubiquitin can be covalently linked to many cellular proteins by the ubiquitination process, which targets proteins for degradation by the 26S proteasome. Three components are involved in the target protein-ubiquitin conjugation process. Ubiquitin is first activated by forming a thiolester complex with the activation component E1; the activated ubiquitin is subsequently transferred to the ubiquitin-carrier protein E2, then from E2 to ubiquitin ligase E3 for final delivery to the epsilon-NH2 of the target protein lysine residue. The ubiquitin-proteasome pathway has been implicated in a wide range of normal biological processes and in disease-related abnormalities. Several proteins such as IκB, p53, cdc25A, and Bcl-2 have been shown to be targets for the ubiquitin-proteasome process as part of regulation of cell cycle progression, differentiation, cell stress response, and apoptosis.
References
[1] Ciechanover, A. (1998) EMBO J 17, 7151-60.
[2] Hochstrasser, M. (2000) Nat Cell Biol 2, E153-7.
[3] Hochstrasser, M. (2000) Science 289, 563-4.
[4] Bernardi, R. et al. (2000) Oncogene 19, 2447-54.
[5] Aberle, H. et al. (1997) EMBO J 16, 3797-804.
[6] Salomoni, P. and Pandolfi, P.P. (2002) Nat Cell Biol 4, E152-3.
[7] Jesenberger, V. and Jentsch, S. (2002) Nat Rev Mol Cell Biol 3, 112-21.
Ubiquitin (P4D1) Mouse mAb Preparation Products And Raw materials
Raw materials
Preparation Products
Ubiquitin (P4D1) Mouse mAb Suppliers
- Tel
- 15921930842 15921930842
- yh-wang@univ-bio.com
- Country
- China
- ProdList
- 25004
- Advantage
- 58
- Tel
- 21-80243558 86218024
- info@cellsignal.cn
- Country
- China
- ProdList
- 6725
- Advantage
- 58
- Tel
- 18926165828
- Country
- CHINA
- ProdList
- 198
- Advantage
- 58
- Tel
- 18675945663
- Country
- CHINA
- ProdList
- 126
- Advantage
- 58
- Tel
- 19815098104
- Country
- CHINA
- ProdList
- 182
- Advantage
- 58
- Tel
- 020-85591192
- Country
- CHINA
- ProdList
- 194
- Advantage
- 58
- Tel
- 010-67500625 18210120938
- 384669408@qq.com
- Country
- China
- ProdList
- 195
- Advantage
- 58
- Tel
- 13969187155
- Country
- CHINA
- ProdList
- 119
- Advantage
- 58
- Tel
- 18248427678
- Country
- CHINA
- ProdList
- 19
- Advantage
- 58
- Tel
- 13185718570
- Country
- CHINA
- ProdList
- 132
- Advantage
- 58