[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-
- Product Name
- [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-
- CAS No.
- 2210228-45-6
- Chemical Name
- [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-
- Synonyms
- SU0268;SU-0268 (SU0268);SU0268, 10 mM in DMSO;MCF-7,Inhibitor,cGAS,OGG1,SU0268,A549,SU 0268,STING,IRF3,inhibit,HeLa,glycosylase,antibacterial,SU-0268;4'-(N-(1-(Cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide;[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-
- CBNumber
- CB55868349
- Molecular Formula
- C26H25N3O4S
- Formula Weight
- 475.56
- MOL File
- 2210228-45-6.mol
[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (10 mg/ml)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BS167477
- Product name
- SU 0268 NEW
- Packaging
- 10mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- BS167477
- Product name
- SU 0268 NEW
- Packaging
- 50mg
- Price
- $612.5
- Updated
- 2021/12/16
[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Chemical Properties,Usage,Production
Description
SU0268 (2210228-45-6) is potent (IC50 = 59 nM) inhibitor of the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1).1,2 Selective versus other DNA repair enzymes (MTH1, DUT, NUDT16, ABH2, ABH3, and SMUG1). SU0268 inhibited proinflammatory responses to Pseudomonas aeruginosa infection in C57BL/6 wild-type mice.3
Uses
SU0268 is a potent and specific inhibitor of 8-Oxoguanine DNA glycosylase 1 (OGG1). SU0268 regulates inflammatory responses during Pseudomonas aeruginosa infection[1][2][3].
in vivo
SU0268 pretreatment (10 mg/kg, intranasally treated) increases survival rates compared with controls without SU0268 pretreatment in MH-S cells and C57BL/6N mice[3].
| Animal Model: | Anesthetized C57BL/6N mice[3]. |
| Dosage: | 10 mg/kg. |
| Administration: | Intranasally treated. |
| Result: | Significantly inhibits inflammatory responses and mitigates P. aeruginosa infection. |
References
[1] YU-KI TAHARA. Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase[J]. Journal of the American Chemical Society, 2018, 140 6: 2105-2114. DOI:10.1021/jacs.7b09316
[2] MELIS KANT. Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products of Oxidatively induced DNA Base Lesions[J]. ACS Chemical Biology, 2020, 16 1: 45-51. DOI:10.1021/acschembio.0c00877
[3] SHUGANG QIN. Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection.[J]. ACS Applied Electronic Materials, 2020: 2231-2242. DOI:10.4049/jimmunol.1901533
[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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