[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-
- Product Name
- [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-
- CAS No.
- 2210228-45-6
- Chemical Name
- [1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-
- Synonyms
- SU0268;SU-0268 (SU0268);MCF-7,Inhibitor,cGAS,OGG1,SU0268,A549,SU 0268,STING,IRF3,inhibit,HeLa,glycosylase,antibacterial,SU-0268;4'-(N-(1-(Cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide;4'-(N-(1-(Cyclopropanecarbonyl)-1,2,3,4-tetrahydroquinolin-7-yl)sulfamoyl)-[1,1'-biphenyl]-3-carboxamide;[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]-
- CBNumber
- CB55868349
- Molecular Formula
- C26H25N3O4S
- Formula Weight
- 475.56
- MOL File
- 2210228-45-6.mol
[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Property
- storage temp.
- -20°C
- solubility
- Soluble in DMSO (10 mg/ml)
- form
- solid
- color
- Off-white
- Stability:
- Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Warning
- Hazard statements
-
H302Harmful if swallowed
H315Causes skin irritation
H319Causes serious eye irritation
H335May cause respiratory irritation
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.
P302+P352IF ON SKIN: wash with plenty of soap and water.
P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
N-Bromosuccinimide Price
- Product number
- BS167477
- Product name
- SU 0268 NEW
- Packaging
- 10mg
- Price
- $175
- Updated
- 2021/12/16
- Product number
- BS167477
- Product name
- SU 0268 NEW
- Packaging
- 50mg
- Price
- $612.5
- Updated
- 2021/12/16
[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Chemical Properties,Usage,Production
Description
SU0268 (2210228-45-6) is potent (IC50 = 59 nM) inhibitor of the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1).1,2 Selective versus other DNA repair enzymes (MTH1, DUT, NUDT16, ABH2, ABH3, and SMUG1). SU0268 inhibited proinflammatory responses to Pseudomonas aeruginosa infection in C57BL/6 wild-type mice.3
References
Tahara et al. (2018), Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase; J. Am. Chem. Soc., 140 2105 Kant et al. (2021), Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products if Oxidatively induced DNA Base Lesions; ACS Chem. Biol., 16 45 Qin et al. (2020), Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection; J. Immunol., 205 2231
[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Preparation Products And Raw materials
Raw materials
Preparation Products
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