[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Property

storage temp. 

-20°C

solubility 

Soluble in DMSO (10 mg/ml)

form 

solid

color 

Off-white

Stability:

Stable for 2 years from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months.

Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P301+P312IF SWALLOWED: call a POISON CENTER or doctor/physician IF you feel unwell.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

[1,1'-Biphenyl]-3-carboxamide, 4'-[[[1-(cyclopropylcarbonyl)-1,2,3,4-tetrahydro-7-quinolinyl]amino]sulfonyl]- Chemical Properties,Usage,Production

Description

SU0268 (2210228-45-6) is potent (IC50 = 59 nM) inhibitor of the DNA repair enzyme 8-oxoguanine DNA glycosylase (OGG1).1,2 Selective versus other DNA repair enzymes (MTH1, DUT, NUDT16, ABH2, ABH3, and SMUG1). SU0268 inhibited proinflammatory responses to Pseudomonas aeruginosa infection in C57BL/6 wild-type mice.3

References

Tahara et al. (2018), Potent and Selective Inhibitors of 8-Oxoguanine DNA Glycosylase; J. Am. Chem. Soc., 140 2105 Kant et al. (2021), Inhibition by Tetrahydroquinoline Sulfonamide Derivatives of the Activity of Human 8-Oxoguanine DNA Glycosylase (OGG1) for Several Products if Oxidatively induced DNA Base Lesions; ACS Chem. Biol., 16 45 Qin et al. (2020), Small-Molecule Inhibitor of 8-Oxoguanine DNA Glycosylase 1 Regulates Inflammatory Responses during Pseudomonas aeruginosa Infection; J. Immunol., 205 2231