LQZ-7I
- Product Name
- LQZ-7I
- CAS No.
- 195822-23-2
- Chemical Name
- LQZ-7I
- Synonyms
- LQZ-7I;LQZ-7I, 10 mM in DMSO;N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine;2,3-Quinoxalinediamine, N2,N3-bis(4-fluorophenyl)-;LQZ7I,inhibit,Survivin,LQZ 7I,Inhibitor,tumor,LQZ-7I,dimerization
- CBNumber
- CB56193512
- Molecular Formula
- C20H14F2N4
- Formula Weight
- 348.35
- MOL File
- 195822-23-2.mol
LQZ-7I Property
- Melting point:
- 203 °C(Solv: ethanol (64-17-5))
- Boiling point:
- 470.3±45.0 °C(Predicted)
- Density
- 1.390±0.06 g/cm3(Predicted)
- storage temp.
- Keep in dark place,Inert atmosphere,Room temperature
- solubility
- DMSO: 125 mg/mL (358.83 mM)
- form
- A solid
- pka
- 2.56±0.59(Predicted)
- color
- Light yellow to green yellow
Hazard and Precautionary Statements (GHS)
- Symbol(GHS)
-
- Signal word
- Danger
- Hazard statements
-
H314Causes severe skin burns and eye damage
- Precautionary statements
-
P261Avoid breathing dust/fume/gas/mist/vapours/spray.
P264Wash hands thoroughly after handling.
P264Wash skin thouroughly after handling.
P270Do not eat, drink or smoke when using this product.
P271Use only outdoors or in a well-ventilated area.
P280Wear protective gloves/protective clothing/eye protection/face protection.
P301+P330+P331IF SWALLOWED: Rinse mouth. Do NOT induce vomiting.
P303+P361+P353IF ON SKIN (or hair): Remove/Take off Immediately all contaminated clothing. Rinse SKIN with water/shower.
P405Store locked up.
P501Dispose of contents/container to..…
N-Bromosuccinimide Price
- Product number
- A1275711
- Product name
- N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
- Purity
- 98+%
- Packaging
- 1mg
- Price
- $58
- Updated
- 2021/12/16
- Product number
- AS711703
- Product name
- N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
- Purity
- ≥98%
- Packaging
- 5mg
- Price
- $89
- Updated
- 2021/12/16
- Product number
- A1275711
- Product name
- N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
- Purity
- 98+%
- Packaging
- 5mg
- Price
- $90
- Updated
- 2021/12/16
- Product number
- AS711703
- Product name
- N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
- Purity
- ≥98%
- Packaging
- 10mg
- Price
- $139
- Updated
- 2021/12/16
- Product number
- A1275711
- Product name
- N2,N3-Bis(4-fluorophenyl)quinoxaline-2,3-diamine
- Purity
- 98+%
- Packaging
- 10mg
- Price
- $140
- Updated
- 2021/12/16
LQZ-7I Chemical Properties,Usage,Production
Uses
LQZ-7I is a survivin-targeting inhibitor. LQZ-7I inhibits survivin dimerization. LQZ-7I orally effectively inhibits xenograft tumor growth and induces survivin loss in tumors[1].
Biological Activity
LQZ-7I is an inhibitor targeting survivin. It can inhibits survivin dimerization and xenograft tumor growth and induces loss of survivin in the tumor.
in vitro
LQZ-7I has improved cytotoxicity with IC 50 s of 3.1 μM against C4-2 cells and 4.8 μM against PC-3 cells compared with the parent compound LQZ-7.
LQZ-7I (10 μM; 0-6 hours) treatment reduces the expression of survivin. However, LQZ-7I does not reduce the expression of XIAP, CIAP1, and CIAP2. LQZ-7I may be selective to its intended target survivin .
Western Blot Analysis
| Cell Line: | PC- 3 or C4-2 cells |
| Concentration: | 10 μM | Incubation Time: | 0-6 hours |
| Result: | Reduced the expression of survivin. |
in vivo
LQZ-7I (100 mg/kg; oral gavage every other day for a total of ten treatments) significantly suppresses tumor growth without any notable adverse effect on the mice.
| Animal Model: | 6-week old male NSG mice |
| Dosage: | 100 mg/kg; 200 μL vehicle (90% corn oil/10% DMSO) |
| Administration: | td>Oral gavage every other day for a total of ten treatments |
| Result: | Significantly suppressed tumor growth without any notable adverse effect on the mice as indicated by lacking changes in body weight and in wet weight of major organs at the end of the study. |
target
Survivin
References
[1] Robert Peery,et al. Synthesis and Identification of a Novel Lead Targeting Survivin Dimerization for Proteasome-Dependent Degradation. J Med Chem. 2020 Jun 9. DOI:10.1021/acs.jmedchem.0c00475
LQZ-7I Preparation Products And Raw materials
Raw materials
Preparation Products
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