4-Hydroxyindole

Product Name: 4-Hydroxyindole
CAS No.: 2380-94-1
Chemical Name: 4-Hydroxyindole
Synonyms: 1H-INDOL-4-OL;4-Hdroxyindole;4-INDOLOL;INDOL-4-OL;1H-INDOLE-4-OL;4-HydroxyindoL;4-HYDROXYINDOLE;4-Hydroxxyindole;4-Hydroxylndole;4-Hydroxyindole>
CBNumber: CB5663260
Molecular Formula: C8H7NO
Formula Weight: 133.15
MOL File: 2380-94-1.mol

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4-Hydroxyindole Property

Melting point:: 97-99 °C(lit.)
Boiling point:: 245.66°C (rough estimate)
Density: 1.1475 (rough estimate)
vapor pressure: 0.019Pa at 25℃
refractive index: 1.5260 (estimate)
storage temp.: 0-6°C
solubility: DMSO (Slightly), Methanol (Slightly)
form: Solid
pka: 9.89±0.40(Predicted)
color: Dark Yellow to Green-Grey
Water Solubility: slightly soluble
Sensitive: Air Sensitive
BRN: 114905
InChIKey: NLMQHXUGJIAKTH-UHFFFAOYSA-N
LogP: 1.57 at 25℃
CAS DataBase Reference: 2380-94-1(CAS DataBase Reference)

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Safety

Hazard Codes: Xi
Risk Statements: 36/37/38
Safety Statements: 26-36-37/39
WGK Germany: 3
Hazard Note: Irritant
HazardClass: IRRITANT, KEEP COLD
HS Code: 29339900

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: 219878
Product name: 4-Hydroxyindole
Purity: 99%
Packaging: 1g
Price: $64.8
Updated: 2025/07/31

Sigma-Aldrich

Product number: 1327157
Product name: 4-Hydroxyindole
Purity: United States Pharmacopeia (USP) Reference Standard
Packaging: 25MG
Price: $1220
Updated: 2025/07/31

TCI Chemical

Product number: H0582
Product name: 4-Hydroxyindole
Purity: >99.0%(GC)
Packaging: 5g
Price: $51
Updated: 2021/12/16

TCI Chemical

Product number: H0582
Product name: 4-Hydroxyindole
Purity: >99.0%(GC)
Packaging: 25g
Price: $179
Updated: 2021/12/16

TRC

Product number: H943515
Product name: 4-Hydroxyindole
Packaging: 1g
Price: $75
Updated: 2021/12/16

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4-Hydroxyindole Chemical Properties,Usage,Production

Chemical Properties

Off-White Cyrstalline Solid

Uses

4-Hydroxyindole is a Pindolol (P468000) impurity, which is a mixed adrenergic blocker and serotonin 5HT1A-receptor antagonist.

Definition

ChEBI: 4-hydroxyindole is a member of the class of hydroxyindoles that is 1H-indole substituted by a hydroxy group at position 4. It is a member of phenols and a member of hydroxyindoles.

Application

4-Hydroxyindole as simple indoles is the important raw material or intermediate in the synthesis of pharmaceutical products and industrial polymers. It effectively inhibits Abeta peptide-induced amyloid fibril formation and prevent cell death induced by the peptide in culture. It is used for the synthesis of anti-inflammatory angular pyrrolocoumarins.

Preparation

Synthesis of 4-hydroxyindole: Using resorcinol as raw material, 4-oxotetrahydrocoumarone carboxylic acid is prepared by isomerization, catalytic hydrogenation, and cyclization with ethyl bromopyruvate. It was added to methanol solution saturated with ammonia, and the reaction was heated in an autoclave to generate 4-oxotetrahydroindole. Finally, 4-hydroxyindole is obtained by dehydrogenation and isomerization.

General Description

Glucouridination of 4-hydroxyindole by human uridine 5′-diphospho-glucuronosyltransferase has been repotrted.

4-Hydroxyindole Preparation Products And Raw materials

Raw materials

Methanol solution Ethyl bromopyruvate 2,6-Dinitrotoluene tert-Butanol Paraformaldehyde Resorcinol Indole N,N-Dimethylacetamide

Preparation Products

4-(oxiranylmethoxy)-1H-indole Pindolol 4-HO-DET

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4-Hydroxyindole Suppliers

Americas 1 Belgium 2 Canada 3 China 424 Europe 3 Germany 6 India 24 Japan 5 Slovakia 1 South Korea 2 Switzerland 6 Ukraine 1 United Kingdom 22 United States 76 Global 576

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View Lastest Price from 4-Hydroxyindole manufacturers

Hebei Ganmiao New material Technology Co., LTD

Product: 4-Hydroxyindole 2380-94-1
Price: US $13.00-7.00/kg
Min. Order: 1kg
Purity: 99.9%
Supply Ability: 200ton
Release date: 2024-06-19

Henan Fengda Chemical Co., Ltd

Product: 4-Hydroxyindole 2380-94-1
Price: US $122.00-1.00/KG
Min. Order: 1KG
Purity: 99%
Supply Ability: g-kg-tons, free sample is available
Release date: 2024-01-11

LY Global chemicals co.,ltd .

Product: 4-Hydroxyindole 2380-94-1
Price: US $0.00-0.00/g
Min. Order: 1g
Purity: 98%
Supply Ability: 100kg
Release date: 2023-03-09

2380-94-1, 4-HydroxyindoleRelated Search:

Indole-3-acetic acid Indometacin Protocatechuic acid Indole-3-butyric acid Pindolol 2-Methylcyclohexylamine 4,4'-Oxydianiline Bis(1,2,2,6,6-pentamethyl-4-piperidyl) sebacate 1-Chloro-3-(1H-indol-4-yloxy)-2-propanol 4-Benzyloxyindole-3-carboxaldehyde METHYL 4-METHOXY-2-INDOLECARBOXYLATE 4-Methoxyindole-3-carboxaldehyde 3-HYDROXYINDOLE 4-Methoxyindole PSILOCIN 4-Benzyloxyindole 7-HYDROXYINDOLE-2-CARBOXYLIC ACID 4-Hydroxy-2-methylindole

4-Hdroxyindole

4-Hydroxyindole in stock Factory

1H-INDOL-4-OL

1H-INDOLE-4-OL

4-HYDROXY-1H-INDOLE

4-INDOLOL

4-HYDROXYINDOLE

INDOL-4-OL

4-Hydroxy Indole (4-Indolol)

4-Hydroxxyindole

4-Hydroxyindole>99.0%

4-Hydroxyindole,98%

4-Hydroxylndole

4-HYDROXYINDOLE(4OHI)

4-Hydroxyindole,99%

4-Hydroxyindole , 99.0%(GC)

1H-indol-4-ol, 4- hydroxyindole

4-Hydroxyindole≥ 99.5% (HPLC)

1,5-Dihydro-indol-4-one

Pindolol EP Impurity E

4-Hydroxyindole&gt

4-HydroxyindoL

1H-Indol-4-ol (9CI, ACI)

4 Hydroxyindole,4Hydroxyindole

Pindolol Impurity E

4-Hydroxyindole (25 mg) (1H-Indol-4-ol)

4-Hydroxyindole (Standard)

Indololol EP Impurity E

4-Hydroxyindole, 10 mM in DMSO

2380-94-1

Simple Indoles

Indoles

Building Blocks

ALCOHOL

Heterocyclic Building Blocks

API

Chemical

Heterocycle-Indole series

Indole

Indoles

Indole Derivatives

Simple Indoles

Chiral Compound

Pyrroles & Indoles

Heterocycles

blocks

IndolesOxindoles

Indoles and derivatives

pharmacetical

Heterocycles series

Pyrroles & Indoles

bc0001

2380-94-1