ChemicalBook > CAS DataBase List > Pindolol

Pindolol

Product Name
Pindolol
CAS No.
13523-86-9
Chemical Name
Pindolol
Synonyms
lb46;LB-46;Visken;Vasken;dl-lb46;Decreten;Pinbetol;Pynastin;PINDOLOL;(+-)-lb46
CBNumber
CB3105373
Molecular Formula
C14H20N2O2
Formula Weight
248.32
MOL File
13523-86-9.mol
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Pindolol Property

Melting point:
167-171 °C(lit.)
Boiling point:
391.39°C (rough estimate)
Density 
1.0606 (rough estimate)
refractive index 
1.5110 (estimate)
storage temp. 
2-8°C
solubility 
0.1 M NaOH: 0.2 mg/mL
pka
pKa 9.26 (Uncertain)
form 
powder
color 
white to off-white
Water Solubility 
33mg/L(22.5 ºC)
Merck 
13,7525
CAS DataBase Reference
13523-86-9(CAS DataBase Reference)
NIST Chemistry Reference
Pindolol(13523-86-9)
EPA Substance Registry System
2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]- (13523-86-9)
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Safety

Hazard Codes 
Xn
Risk Statements 
22-36/37/38
Safety Statements 
26-36
RIDADR 
3249
WGK Germany 
3
RTECS 
UB6660000
HazardClass 
6.1(b)
PackingGroup 
III
HS Code 
2933995300
Hazardous Substances Data
13523-86-9(Hazardous Substances Data)
Toxicity
LD50 oral in rabbit: 650mg/kg
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Hazard and Precautionary Statements (GHS)

Symbol(GHS)
Signal word
Warning
Hazard statements

H302Harmful if swallowed

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

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N-Bromosuccinimide Price

Sigma-Aldrich
Product number
P0778
Product name
Pindolol
Purity
≥98% (TLC), powder
Packaging
1g
Price
$107
Updated
2020/08/18
Sigma-Aldrich
Product number
P1800000
Product name
Pindolol
Purity
European Pharmacopoeia (EP) Reference Standard
Price
$190
Updated
2021/03/22
Sigma-Aldrich
Product number
1539701
Product name
Pindolol
Purity
United States Pharmacopeia (USP) Reference Standard
Packaging
200mg
Price
$366
Updated
2021/03/22
Cayman Chemical
Product number
21445
Product name
Pindolol
Purity
≥99%
Packaging
50mg
Price
$29
Updated
2021/03/22
Cayman Chemical
Product number
21445
Product name
Pindolol
Purity
≥99%
Packaging
100mg
Price
$55
Updated
2021/03/22
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Pindolol Chemical Properties,Usage,Production

Chemical Properties

White Solid

Originator

Betadren, Lagap

Uses

Mixed β-adrenergic blocker and serotonin 5HT1A-receptor antagonist. Antihypertensive; antianginal; antiarrhythmic; antiglaucoma.

Uses

Pindolol, like nadolol, is a nonselective β-adrenoblocker. It possesses antianginal, antihypotensive, and antiarrythmic action. It is used for arterial hypertension, angina stress (preventing attacks), supraventricular tachycardia, tachsystolic form of atrial fibrillation, and superventricular extrasystole.

Definition

ChEBI: A member of the class of indols which is the 2-hydroxy-3-(isopropylamino)propyl ether derivative of 1H-indol-4-ol.

Manufacturing Process

4-Hydroxyindole is obtained by debenzylation of 4-benzyloxyindole with hydrogen in the presence of a 5% palladium catalyst on aluminium oxide.
10.0 g of 4-hydroxyindole and subsequently 7.4 ml of epichlorohydrin are added while stirring in an atmosphere of nitrogen to a solution of 2.73 g of sodium hydroxide in 65 ml of water. Stirring is effected at room temperaturefor a further 15 h, the reaction mixture is extracted 4 times with 50 ml of methylene chloride and the combined organic layers which have been dried over magnesium sulfate are evaporated at reduced pressure. So 3-chloro-1(4-indolyloxy)-2-propanol is obtained.
The 3-chloro-1-(4-indolyloxy)-2-propanol is dissolved in 50 ml of toluene and 50 ml of isopropylamine and heated to the boil for 45 h. Evaporation to dryness is effected in a vacuum, the residue is shaken out thrice between ethyl acetate and a 1 N tartaric acid solution and a 5 N sodium hydroxide solution is then added to the combined tartaric acid phases until an alkaline reaction is obtained. The alkaline solution is shaken out thrice with 50 ml of methylene chloride, the extracts are dried over magnesium sulfate and the solvent evaporated in vacuum. The residue is crystallized from ethyl acetate/ether to give the 4-(2-hydroxy-3-isopropylaminopropoxy)indole.

brand name

Visken (Novartis).

Therapeutic Function

Beta-adrenergic blocker

Biological Activity

5-HT 1A/1B ? receptor antagonist, with roughly equal affinity for each subtype. A partial agonist at mouse and human β 3 -adrenoceptors.

Metabolic pathway

Several metabolites of pindolol formed in vitro are detected after a 24 h incubation of human hepatocytes in both pure culture and co-culture by adding rat liver epithelial cells. The hepatocytes are able to oxidize the isopropyl amine moiety and the pyrrole ring of the indole moiety and conjugate pindolol as sulfates and glucuronides.

Metabolism

Pindolol (Visken) is extensively absorbed from the gastrointestinal tract. First-pass metabolism is estimated at about 15%, and its plasma half-life is on the order of 3 to 4 hours.The binding of pindolol to plasma proteins is approximately 50%.The metabolic fate of pindolol is not completely understood, although 50% of an administered dose is recovered, primarily in the urine, as unchanged drug.

Pindolol Preparation Products And Raw materials

Raw materials

Preparation Products

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Pindolol Suppliers

3B Pharmachem (Wuhan) International Co.,Ltd.
Tel
821-50328103-801
Fax
86-21-50328109
Email
3bsc@sina.com
Country
China
ProdList
15877
Advantage
69
Chemsky(shanghai)International Co.,Ltd.
Tel
021-50135380
Email
shchemsky@sina.com
Country
China
ProdList
32358
Advantage
50
Beijing HuaMeiHuLiBiological Chemical
Tel
010-56205725;010-86181995
Fax
010-65763397
Email
waley188@sohu.com
Country
China
ProdList
12341
Advantage
58
MedChemexpress LLC
Tel
609-228-6898
Fax
609-228-5909
Email
sales@medchemexpress.com
Country
United States
ProdList
4787
Advantage
58
Shanghai TaoShu Biochemical Technology Co., Ltd.
Tel
021-33632979-
Fax
021-33632979
Email
service1@targetmol.com
Country
China
ProdList
7962
Advantage
58
ChemStrong Scientific Co.,Ltd
Tel
0755-66853366-
Email
sales@chem-strong.com
Country
China
ProdList
26596
Advantage
56
Jiangsu Aikon Biopharmaceutical R&D co.,Ltd.
Tel
025-66099280-
Email
sales01@aikonchem.com
Country
China
ProdList
15390
Advantage
50
Chizhou Kailong Import and Export Trade Co., Ltd.
Tel
Please Email
Fax
-
Email
xg01_gj@163.com
Country
China
ProdList
9550
Advantage
50
Sigma-Aldrich
Tel
021-61415566- ;
Email
orderCN@merckgroup.com;orderCN@merckgroup.com
Country
China
ProdList
48786
Advantage
80
Alta Scientific Co., Ltd.
Tel
022-65378550- ;022-65378550-
Fax
022-2532-9655
Email
sales@altascientific.com;marketing@altascientific.com
Country
China
ProdList
9070
Advantage
55
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View Lastest Price from Pindolol manufacturers

Dideu Industries Group Limited
Product
Pindolol USP/EP/BP 13523-86-9
Price
US $1.10/g
Min. Order
1g
Purity
99.9%
Supply Ability
100 Tons min
Release date
2021-08-11
Shaanxi Dideu Medichem Co. Ltd
Product
Pindolol 13523-86-9
Price
US $1.00-1.00/KG
Min. Order
1g
Purity
99%
Supply Ability
50tons
Release date
2020-05-11
Zhuozhou Wenxi import and Export Co., Ltd
Product
Pindolol 13523-86-9
Price
US $15.00-10.00/KG
Min. Order
1KG
Purity
99%+ HPLC
Supply Ability
Monthly supply of 1 ton
Release date
2021-07-10

13523-86-9, PindololRelated Search:


  • (+-)-4-(2-hydroxy-3-(isopropylamino)propoxy)indole
  • (+-)-lb46
  • (rs)-pindolol
  • carvisken
  • Decreten
  • dl-4-(2-hydroxy-3-(isopropylamino)propoxy)indole
  • dl-lb46
  • dl-pindolol
  • Durapindol
  • Glauco-visken
  • glauco-viskin
  • lb46
  • LB-46
  • Pectobloc
  • Pinbetol
  • Prinodolol
  • Pynastin
  • 1-(1H-INDOL-4-YLOXY)-3-[(1-METHYLETHYL)AMINO]-2-PROPANOL
  • 1-[1H-INDOL-4-YLOXY]-3-[ISOPROPYLAMINO]-2-PROPANOL
  • 1-(INDOL-4-YLOXY)-3-(ISOPROPYLAMINO)-2-PROPANOL
  • PINDOLOL
  • 1-((1-methylethyl)amino)-3-(4-indolyloxy)-2-propanol
  • 1-(1h-indol-4-yloxy)-3-((1-methylethyl)amino)-2-propano
  • 1-(4-indolyloxy)-3-(isopropylamino)-2-propano
  • 1-(4-Indolyloxy)-3-(isopropylamino)-2-propanol
  • 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]-
  • 2-Propanol, 1-(4-indolyloxy)-3-(isopropylamino)-
  • 4-(2-Hydroxy-3-isopropylaminopropoxy)-indole
  • 4-(3-(isopropylamino)-2-hydroxypropoxy)indole
  • 4-[2-hydroxy-3-(isopropylamino)-propoxy]indole
  • Betapindol
  • Blockin L
  • Blocklin L
  • blocklinl
  • Calvisken
  • Cardilate
  • Visken
  • PINDOLOL 97%
  • PINDOLOL VASODILATOR
  • PINDOLOL,USP
  • 2-Propanol, 1-(1H-indol-4-yloxy)-3-[(1-methylethyl)amino]- (9CI)
  • 2-Propanol, 1-(indol-4-yloxy)-3-(isopropylamino)- (8CI)
  • N-[2-Hydroxy-3-(1H-indol-4-yloxy)propyl]-N-isopropylamine
  • Vasken
  • Pindolol & 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
  • Pindolol,1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
  • Pindolol (200 mg)
  • 1-(1H-Indol-4-yloxy)-3-(isopropylamino)-2-propanol, 1-(1H-Indol-4-yloxy)-3-[(1-methylethyl)amino]-2-propanol
  • 1-(1H-Indol-4-yloxy)-3-[(1-Methylethyl)aMino]-
  • Pindolol CRS
  • Pindolol USP/EP/BP
  • 13523-86-9
  • C14H21N2O2
  • 24832
  • ALCOHOL
  • VISKEN
  • Serotonin receptor
  • Indole Derivatives