(-)-INDOLACTAM V

Product Name: (-)-INDOLACTAM V
CAS No.: 90365-57-4
Chemical Name: (-)-INDOLACTAM V
Synonyms: (-)-Ilv;IndolactaM;Brn 4711877;()-Indolactam V;(-)-INDOLACTAM V;(-)-Indolactam V;(-)-Indolactam V ()Indolactam V,( ) Indolactam V;(-)-Indolactam V, PKC activator;(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl)
CBNumber: CB2244996
Molecular Formula: C17H23N3O2
Formula Weight: 301.38
MOL File: 90365-57-4.mol

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(-)-INDOLACTAM V Property

Boiling point:: 584.0±50.0 °C(Predicted)
Density: 1.166±0.06 g/cm3(Predicted)
storage temp.: -20°C
solubility: DMSO: >10mg/mL, clear
form: white powder
pka: 14.39±0.10(Predicted)
color: White to light yellow
Stability:: Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 2 months.

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Safety

WGK Germany: 3
RTECS: UY8547000

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Hazard and Precautionary Statements (GHS)

Symbol(GHS)

Signal word

Warning

Hazard statements

H315Causes skin irritation

H319Causes serious eye irritation

H335May cause respiratory irritation

Precautionary statements

P261Avoid breathing dust/fume/gas/mist/vapours/spray.

P264Wash hands thoroughly after handling.

P264Wash skin thouroughly after handling.

P271Use only outdoors or in a well-ventilated area.

P280Wear protective gloves/protective clothing/eye protection/face protection.

P302+P352IF ON SKIN: wash with plenty of soap and water.

P304+P340IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.

P305+P351+P338IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

P312Call a POISON CENTER or doctor/physician if you feel unwell.

P332+P313IF SKIN irritation occurs: Get medical advice/attention.

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N-Bromosuccinimide Price

Sigma-Aldrich

Product number: I0661
Product name: (?)-Indolactam V
Purity: ≥96% (HPLC)
Packaging: 1mg
Price: $354
Updated: 2024/03/01

Cayman Chemical

Product number: 14647
Product name: (-)-Indolactam V
Purity: ≥95%
Packaging: 500μg
Price: $158
Updated: 2024/03/01

Cayman Chemical

Product number: 14647
Product name: (?)-Indolactam V
Purity: ≥97%
Packaging: 1mg
Price: $299
Updated: 2024/03/01

Cayman Chemical

Product number: 14647
Product name: (?)-Indolactam V
Purity: ≥97%
Packaging: 300μg
Price: $120
Updated: 2021/12/16

TRC

Product number: I577325
Product name: (-)-IndolactamV
Packaging: 10mg
Price: $4195
Updated: 2021/12/16

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(-)-INDOLACTAM V Chemical Properties,Usage,Production

Description

Indolactam V (-) (90365-57-4) is a PKC activator acting at the phorbol ester binding site.1,2?Directs differentiation of human and mouse ESCs to pancreatic cells.3?? May be used, along with other agents, to differentiate human iPS cells into glucose-responsive insulin-secreting progeny.4?Increases regulator of G protein signaling 2 (RGS2) protein levels, a protein that regulates GPCR signaling.5

Uses

(-)-Indolactam V is an indole alkaloid compound which activates protein kinase C (PKC). Weak tumor promoter. Also directs differentiation of human embryonic stem cells, potentially into pancreatic lineage allowing for an effective diabetes therapy.

Definition

ChEBI: (-)-indolactam V is a 9-membered ring that is a potent protein kinase C activator

Biological Activity

Protein kinase C activator. Exhibits tumor promoting activity. Directs differentiation of human embryonic stem cells (ESCs) into pancreatic progenitors.

Biochem/physiol Actions

(-)-Indolactam V is a PKC activator shown to effect differentiation in embryonic stem cells leading to development of pancreatic precursors. It is active in the mouse model.

storage

-20°C (desiccate)

References

1) Fujiki?et al.?(1984),?Structure-activity studies on synthetic analogues (indolactams) of the tumor promoter teleocidin; Gan., 75?866 2) Heikkila and Ackerman (1989),?(-)-Indolactam V activates protein kinase C and induces changes in muscarinic receptor functions in SH-SY5Y human neuroblastoma cells; Biochem. Biophys. Res. Commun,?162?1207 3) Chen?et al.?(2009),?A small molecule that directs differentiation of human ESCs into the pancreatic lineage; Nat. Chem. Biol.,?5?258 4) Thalava?et al. (2011),?Indolactam V/GLP-1-mediated differentiation of human iPS cells into glucose-responsive insulin-secretin progeny; Gene Ther.,?18?283 5) Raveh (2014),?Identification of protein kinase C activation as a novel mechanism for RGS2 protein upregulation through phenotypic screening of natural product extracts; Mol. Pharmacol.,?86?406

(-)-INDOLACTAM V Preparation Products And Raw materials

Raw materials

Preparation Products

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(-)-INDOLACTAM V Suppliers

China 27 Czech 1 Germany 1 Switzerland 3 Ukraine 1 United Kingdom 3 United States 14 Global 50

3B Pharmachem (Wuhan) International Co.,Ltd.

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Sigma-Aldrich

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Nanjing Meihao Pharmaceutical Technology Co., Ltd.

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90365-57-4, (-)-INDOLACTAM VRelated Search:

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(2s-(2r*,5r*))-ethyl)-1-methyl-2-(1-methylethyl)

3h-pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one,1,2,4,5,6,8-hexahydro-5-(hydroxym

(-)-INDOLACTAM V

(2S,5S)-1,2,4,5,6,8-Hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-3H-pyrrolo[4,3,2-gh]-1,4-benzodiazonin-3-one

(-)-Ilv

3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S-(2R*,5R*))-

3H-Pyrrolo(4,3,2-gh)-1,4-benzodiazonin-3-one, 1,2,4,5,6,8-hexahydro-5-(hydroxymethyl)-1-methyl-2-(1-methylethyl)-, (2S,5S)-

Brn 4711877

IndolactaM

(-)-Indolactam V&nbsp

()-Indolactam V

(-)-Indolactam V

()Indolactam V,( ) Indolactam V

(2S,5S)-5-(Hydroxymethyl)-2-isopropyl-1-methyl-4,5,6,8-tetrahydro-1H-[1,4]diazonino[7,6,5-cd]indol-3(2H)-one

(-)-Indolactam V, PKC activator

90365-57-4